UniProtKB - A1A5P0 (BORG5_RAT)
Protein
Cdc42 effector protein 1
Gene
Cdc42ep1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts (By similarity).By similarity
GO - Biological processi
- positive regulation of actin filament polymerization Source: GO_Central
- positive regulation of pseudopodium assembly Source: RGD
- regulation of cell shape Source: RGD
- Rho protein signal transduction Source: RGD
Keywordsi
Biological process | Cell shape |
Names & Taxonomyi
Protein namesi | Recommended name: Cdc42 effector protein 1Alternative name(s): Binder of Rho GTPases 5 |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1311131, Cdc42ep1 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
- Endomembrane system By similarity; Peripheral membrane protein By similarity
Cytoskeleton
- cytoskeleton Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: RGD
- endomembrane system Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000278120 | 1 – 388 | Cdc42 effector protein 1Add BLAST | 388 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | PhosphoserineBy similarity | 1 | |
Modified residuei | 27 | PhosphoserineBy similarity | 1 | |
Modified residuei | 34 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 39 | PhosphoserineBy similarity | 1 | |
Modified residuei | 53 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 65 | PhosphoserineBy similarity | 1 | |
Modified residuei | 77 | PhosphoserineBy similarity | 1 | |
Modified residuei | 101 | PhosphoserineBy similarity | 1 | |
Modified residuei | 113 | PhosphoserineBy similarity | 1 | |
Modified residuei | 121 | PhosphoserineCombined sources | 1 | |
Modified residuei | 139 | PhosphoserineBy similarity | 1 | |
Modified residuei | 193 | PhosphoserineBy similarity | 1 | |
Modified residuei | 207 | PhosphoserineCombined sources | 1 | |
Modified residuei | 209 | PhosphoserineCombined sources | 1 | |
Modified residuei | 212 | PhosphoserineBy similarity | 1 | |
Modified residuei | 298 | PhosphoserineCombined sources | 1 | |
Modified residuei | 318 | PhosphoserineCombined sources | 1 | |
Modified residuei | 347 | PhosphoserineCombined sources | 1 | |
Modified residuei | 350 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
PaxDbi | A1A5P0 |
PeptideAtlasi | A1A5P0 |
PRIDEi | A1A5P0 |
PTM databases
iPTMneti | A1A5P0 |
PhosphoSitePlusi | A1A5P0 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000008517, Expressed in stomach and 21 other tissues |
Genevisiblei | A1A5P0, RN |
Interactioni
Subunit structurei
Interacts with RHOQ and CDC42, in a GTP-dependent manner.
By similarityProtein-protein interaction databases
IntActi | A1A5P0, 2 interactors |
STRINGi | 10116.ENSRNOP00000011269 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 52 | CRIBPROSITE-ProRule annotationAdd BLAST | 15 | |
Repeati | 237 – 243 | 1Sequence analysis | 7 | |
Repeati | 250 – 256 | 2Sequence analysis | 7 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 237 – 270 | 2 X 7 AA tandem repeats of [PT]-[AT]-A-[ENT]-[PT]-[PTS]-[AG]Sequence analysisAdd BLAST | 34 |
Domaini
The CRIB domain mediates interaction with CDC42.By similarity
Sequence similaritiesi
Belongs to the BORG/CEP family.Sequence analysis
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502RZ2H, Eukaryota |
GeneTreei | ENSGT00940000160068 |
HOGENOMi | CLU_787446_0_0_1 |
InParanoidi | A1A5P0 |
OMAi | QLNQATY |
OrthoDBi | 1244464at2759 |
PhylomeDBi | A1A5P0 |
TreeFami | TF331725 |
Family and domain databases
InterProi | View protein in InterPro IPR029273, Cdc42_effect IPR000095, CRIB_dom |
Pfami | View protein in Pfam PF14957, BORG_CEP, 1 hit PF00786, PBD, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit |
i Sequence
Sequence statusi: Complete.
A1A5P0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGPQGGTGA PSMSLGKLSP VGWVPSSHGK RRLTADMISP PLGDFRHTMH
60 70 80 90 100
VGRGGDVFGD TSFLSNHGGR SGNTHRSPRS FLARKLQQVR RVGVPPRRMA
110 120 130 140 150
SPAATSPAPP PISPIIKNAI SLPQLNQATY DSLVVSKLSF DSTPASSTDG
160 170 180 190 200
RSGYGLESGF CTISRLPRVE KHSSRDRDHD RDPDHSQDRE QSSSPSEPNP
210 220 230 240 250
NPELRRSDSL LSFRFDLDLG PSLLSELLGV MSLSEAPAAN PPAPAANPAP
260 270 280 290 300
TAKPPADAVT TLDTVTSLPA PTASSPSSGR FPNGVTAVLG PVAEVKASPV
310 320 330 340 350
GEGPQVPSKM AFDRRGASWG AIRASRHYTE MDARRELAGV LPQVHGSWES
360 370 380
LNEEWSAPPA SSRAPVPSTV QANAFEFADA DEDDEVKV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC128744 mRNA Translation: AAI28745.1 |
RefSeqi | NP_001073168.1, NM_001079700.1 XP_017450354.1, XM_017594865.1 XP_017450355.1, XM_017594866.1 XP_017450356.1, XM_017594867.1 XP_017450357.1, XM_017594868.1 |
Genome annotation databases
Ensembli | ENSRNOT00000011270; ENSRNOP00000011269; ENSRNOG00000008517 |
GeneIDi | 315121 |
KEGGi | rno:315121 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC128744 mRNA Translation: AAI28745.1 |
RefSeqi | NP_001073168.1, NM_001079700.1 XP_017450354.1, XM_017594865.1 XP_017450355.1, XM_017594866.1 XP_017450356.1, XM_017594867.1 XP_017450357.1, XM_017594868.1 |
3D structure databases
SMRi | A1A5P0 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A1A5P0, 2 interactors |
STRINGi | 10116.ENSRNOP00000011269 |
PTM databases
iPTMneti | A1A5P0 |
PhosphoSitePlusi | A1A5P0 |
Proteomic databases
PaxDbi | A1A5P0 |
PeptideAtlasi | A1A5P0 |
PRIDEi | A1A5P0 |
Genome annotation databases
Ensembli | ENSRNOT00000011270; ENSRNOP00000011269; ENSRNOG00000008517 |
GeneIDi | 315121 |
KEGGi | rno:315121 |
Organism-specific databases
CTDi | 11135 |
RGDi | 1311131, Cdc42ep1 |
Phylogenomic databases
eggNOGi | ENOG502RZ2H, Eukaryota |
GeneTreei | ENSGT00940000160068 |
HOGENOMi | CLU_787446_0_0_1 |
InParanoidi | A1A5P0 |
OMAi | QLNQATY |
OrthoDBi | 1244464at2759 |
PhylomeDBi | A1A5P0 |
TreeFami | TF331725 |
Miscellaneous databases
PROi | PR:A1A5P0 |
Gene expression databases
Bgeei | ENSRNOG00000008517, Expressed in stomach and 21 other tissues |
Genevisiblei | A1A5P0, RN |
Family and domain databases
InterProi | View protein in InterPro IPR029273, Cdc42_effect IPR000095, CRIB_dom |
Pfami | View protein in Pfam PF14957, BORG_CEP, 1 hit PF00786, PBD, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BORG5_RAT | |
Accessioni | A1A5P0Primary (citable) accession number: A1A5P0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families