Cdc42ep1

Functionⁱ

Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts (By similarity).By similarity

GO - Molecular functionⁱ

GTPase activator activity Source: GO_Central
GTP-Rho binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of actin filament polymerization Source: GO_Central
positive regulation of pseudopodium assembly Source: GO_Central
regulation of cell shape Source: GO_Central
Rho protein signal transduction Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell shape

Biological process

Cell shape

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cdc42 effector protein 1 Alternative name(s): Binder of Rho GTPases 5
Gene namesⁱ	Name:Cdc42ep1Imported Synonyms:Borg5By similarity
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 7

Organism-specific databases

Rat genome database More...RGDⁱ	1311131 Cdc42ep1

RGDⁱ

1311131 Cdc42ep1

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000278120	1 – 388	Cdc42 effector protein 1Add BLAST		388

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	19	PhosphoserineBy similarity	1
Modified residueⁱ	27	PhosphoserineBy similarity	1
Modified residueⁱ	34	PhosphothreonineBy similarity	1
Modified residueⁱ	39	PhosphoserineBy similarity	1
Modified residueⁱ	53	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	65	PhosphoserineBy similarity	1
Modified residueⁱ	77	PhosphoserineBy similarity	1
Modified residueⁱ	101	PhosphoserineBy similarity	1
Modified residueⁱ	113	PhosphoserineBy similarity	1
Modified residueⁱ	121	PhosphoserineCombined sources	1
Modified residueⁱ	139	PhosphoserineBy similarity	1
Modified residueⁱ	193	PhosphoserineBy similarity	1
Modified residueⁱ	207	PhosphoserineCombined sources	1
Modified residueⁱ	209	PhosphoserineCombined sources	1
Modified residueⁱ	212	PhosphoserineBy similarity	1
Modified residueⁱ	298	PhosphoserineCombined sources	1
Modified residueⁱ	318	PhosphoserineCombined sources	1
Modified residueⁱ	347	PhosphoserineCombined sources	1
Modified residueⁱ	350	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	A1A5P0
PeptideAtlas More...PeptideAtlasⁱ	A1A5P0
PRIDEⁱ	A1A5P0

PTM databases

iPTMnetⁱ	A1A5P0
PhosphoSitePlusⁱ	A1A5P0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000008517 Expressed in 10 organ(s), highest expression level in lung
Genevisibleⁱ	A1A5P0 RN

Interactionⁱ

Subunit structureⁱ

Interacts with RHOQ and CDC42, in a GTP-dependent manner.By similarity

GO - Molecular functionⁱ

GTP-Rho binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000011269

STRINGⁱ

10116.ENSRNOP00000011269

Structureⁱ

3D structure databases

SMRⁱ	A1A5P0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	38 – 52	CRIBPROSITE-ProRule annotationAdd BLAST	15
Repeatⁱ	237 – 243	1Sequence analysis	7
Repeatⁱ	250 – 256	2Sequence analysis	7

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	237 – 270	2 X 7 AA tandem repeats of [PT]-[AT]-A-[ENT]-[PT]-[PTS]-[AG]Sequence analysisAdd BLAST		34

Domainⁱ

The CRIB domain mediates interaction with CDC42.By similarity

Sequence similaritiesⁱ

Belongs to the BORG/CEP family.Sequence analysis

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IGPN Eukaryota ENOG4111PPX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110869
HOGENOMⁱ	HOG000095252
HOVERGENⁱ	HBG080906
InParanoidⁱ	A1A5P0
OMAⁱ	QANTFEF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IY8
PhylomeDBⁱ	A1A5P0
TreeFamⁱ	TF331725

Family and domain databases

InterProⁱ	View protein in InterPro IPR029273 Cdc42_effect IPR000095 CRIB_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14957 BORG_CEP, 1 hit PF00786 PBD, 1 hit
SMARTⁱ	View protein in SMART SM00285 PBD, 1 hit
PROSITEⁱ	View protein in PROSITE PS50108 CRIB, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A1A5P0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPGPQGGTGA PSMSLGKLSP VGWVPSSHGK RRLTADMISP PLGDFRHTMH 
        60         70         80         90        100
VGRGGDVFGD TSFLSNHGGR SGNTHRSPRS FLARKLQQVR RVGVPPRRMA 
       110        120        130        140        150
SPAATSPAPP PISPIIKNAI SLPQLNQATY DSLVVSKLSF DSTPASSTDG 
       160        170        180        190        200
RSGYGLESGF CTISRLPRVE KHSSRDRDHD RDPDHSQDRE QSSSPSEPNP 
       210        220        230        240        250
NPELRRSDSL LSFRFDLDLG PSLLSELLGV MSLSEAPAAN PPAPAANPAP 
       260        270        280        290        300
TAKPPADAVT TLDTVTSLPA PTASSPSSGR FPNGVTAVLG PVAEVKASPV 
       310        320        330        340        350
GEGPQVPSKM AFDRRGASWG AIRASRHYTE MDARRELAGV LPQVHGSWES 
       360        370        380 
LNEEWSAPPA SSRAPVPSTV QANAFEFADA DEDDEVKV

Length:388

Mass (Da):41,029

Last modified:January 23, 2007 - v1

Checksum:ⁱ62D900F6AEDBEC3E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC128744 mRNA Translation: AAI28745.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001073168.1, NM_001079700.1 XP_017450354.1, XM_017594865.1 XP_017450355.1, XM_017594866.1 XP_017450356.1, XM_017594867.1 XP_017450357.1, XM_017594868.1
UniGeneⁱ	Rn.164707

Genome annotation databases

Ensemblⁱ	ENSRNOT00000011270; ENSRNOP00000011269; ENSRNOG00000008517
GeneIDⁱ	315121
KEGGⁱ	rno:315121

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A1A5P0	Cdc42 effector protein 1		HUMAN		391	UniRef50_Q00587
Cdc42 effector protein 1		MOUSE		409
Cdc42 effector protein 1		BOVIN		361
Uncharacterized protein		PAPAN		398
CDC42 effector protein 1		MACNE		398
+137

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC128744 mRNA Translation: AAI28745.1
RefSeqⁱ	NP_001073168.1, NM_001079700.1 XP_017450354.1, XM_017594865.1 XP_017450355.1, XM_017594866.1 XP_017450356.1, XM_017594867.1 XP_017450357.1, XM_017594868.1
UniGeneⁱ	Rn.164707

3D structure databases

SMRⁱ	A1A5P0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000011269

STRINGⁱ

10116.ENSRNOP00000011269

PTM databases

iPTMnetⁱ	A1A5P0
PhosphoSitePlusⁱ	A1A5P0

Proteomic databases

PaxDbⁱ	A1A5P0
PeptideAtlasⁱ	A1A5P0
PRIDEⁱ	A1A5P0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000011270; ENSRNOP00000011269; ENSRNOG00000008517
GeneIDⁱ	315121
KEGGⁱ	rno:315121

Organism-specific databases

CTDⁱ	11135
RGDⁱ	1311131 Cdc42ep1

Phylogenomic databases

eggNOGⁱ	ENOG410IGPN Eukaryota ENOG4111PPX LUCA
GeneTreeⁱ	ENSGT00730000110869
HOGENOMⁱ	HOG000095252
HOVERGENⁱ	HBG080906
InParanoidⁱ	A1A5P0
OMAⁱ	QANTFEF
OrthoDBⁱ	EOG091G0IY8
PhylomeDBⁱ	A1A5P0
TreeFamⁱ	TF331725

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:A1A5P0

PROⁱ

PR:A1A5P0

Gene expression databases

Bgeeⁱ	ENSRNOG00000008517 Expressed in 10 organ(s), highest expression level in lung
Genevisibleⁱ	A1A5P0 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR029273 Cdc42_effect IPR000095 CRIB_dom
Pfamⁱ	View protein in Pfam PF14957 BORG_CEP, 1 hit PF00786 PBD, 1 hit
SMARTⁱ	View protein in SMART SM00285 PBD, 1 hit
PROSITEⁱ	View protein in PROSITE PS50108 CRIB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BORG5_RAT
Accessionⁱ	A1A5P0Primary (citable) accession number: A1A5P0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Annotation systems

Supporting data

UniProtKB - A1A5P0 (BORG5_RAT)

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Cdc42 effector protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ