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Entry version 103 (13 Feb 2019)
Sequence version 2 (23 Oct 2007)
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Protein

Solute carrier family 22 member 23

Gene

SLC22A23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.19.28 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 22 member 23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC22A23
Synonyms:C6orf85
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137266.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21106 SLC22A23

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611697 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A1A5C7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Transmembranei494 – 514HelicalSequence analysisAdd BLAST21
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Transmembranei569 – 589HelicalSequence analysisAdd BLAST21
Transmembranei598 – 618HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
63027

Open Targets

More...
OpenTargetsi
ENSG00000137266

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162403516

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC22A23

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003083151 – 686Solute carrier family 22 member 23Add BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1A5C7

PRoteomics IDEntifications database

More...
PRIDEi
A1A5C7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
113
114 [A1A5C7-2]
115 [A1A5C7-3]
116 [A1A5C7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1A5C7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A1A5C7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137266 Expressed in 189 organ(s), highest expression level in bronchial epithelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1A5C7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1A5C7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014697

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121960, 17 interactors

Protein interaction database and analysis system

More...
IntActi
A1A5C7, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000385028

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A1A5C7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0255 Eukaryota
ENOG410ZZ6M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157354

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000124569

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108437

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1A5C7

KEGG Orthology (KO)

More...
KOi
K08215

Database of Orthologous Groups

More...
OrthoDBi
292012at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1A5C7

TreeFam database of animal gene trees

More...
TreeFami
TF335753

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083 Sugar_tr, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A1A5C7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAIDRRREAA GGGPGRQPAP AEENGSLPPG DAAASAPLGG RAGPGGGAEI
60 70 80 90 100
QPLPPLHPGG GPHPSCCSAA AAPSLLLLDY DGSVLPFLGG LGGGYQKTLV
110 120 130 140 150
LLTWIPALFI GFSQFSDSFL LDQPNFWCRG AGKGTELAGV TTTGRGGDMG
160 170 180 190 200
NWTSLPTTPF ATAPWEAAGN RSNSSGADGG DTPPLPSPPD KGDNASNCDC
210 220 230 240 250
RAWDYGIRAG LVQNVVSKWD LVCDNAWKVH IAKFSLLVGL IFGYLITGCI
260 270 280 290 300
ADWVGRRPVL LFSIIFILIF GLTVALSVNV TMFSTLRFFE GFCLAGIILT
310 320 330 340 350
LYALRIELCP PGKRFMITMV ASFVAMAGQF LMPGLAALCR DWQVLQALII
360 370 380 390 400
CPFLLMLLYW SIFPESLRWL MATQQFESAK RLILHFTQKN RMNPEGDIKG
410 420 430 440 450
VIPELEKELS RRPKKVCIVK VVGTRNLWKN IVVLCVNSLT GYGIHHCFAR
460 470 480 490 500
SMMGHEVKVP LLENFYADYY TTASIALVSC LAMCVVVRFL GRRGGLLLFM
510 520 530 540 550
ILTALASLLQ LGLLNLIGKY SQHPDSGMSD SVKDKFSIAF SIVGMFASHA
560 570 580 590 600
VGSLSVFFCA EITPTVIRCG GLGLVLASAG FGMLTAPIIE LHNQKGYFLH
610 620 630 640 650
HIIFACCTLI CIICILLLPE SRDQNLPENI SNGEHYTRQP LLPHKKGEQP
660 670 680
LLLTNAELKD YSGLHDAAAA GDTLPEGATA NGMKAM
Length:686
Mass (Da):73,748
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i035E53BA5FEDF8F0
GO
Isoform 2 (identifier: A1A5C7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.

Show »
Length:405
Mass (Da):44,784
Checksum:iBCC8C2E7604B01AB
GO
Isoform 3 (identifier: A1A5C7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-370: Missing.

Note: No experimental confirmation available.
Show »
Length:316
Mass (Da):34,575
Checksum:i6425832AE65DB2D5
GO
Isoform 4 (identifier: A1A5C7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-686: Missing.

Note: No experimental confirmation available.
Show »
Length:361
Mass (Da):38,049
Checksum:iAAA34339879322DC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J4Z0C9J4Z0_HUMAN
Solute carrier family 22 member 23
SLC22A23
694Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZW5C9IZW5_HUMAN
Solute carrier family 22 member 23
SLC22A23
386Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4T9H7C4T9_HUMAN
Solute carrier family 22 member 23
SLC22A23
440Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBC7F8WBC7_HUMAN
Solute carrier family 22 member 23
SLC22A23
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD18753 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti685A → G in BAD18753 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0289551 – 370Missing in isoform 3. 1 PublicationAdd BLAST370
Alternative sequenceiVSP_0289541 – 281Missing in isoform 2. 1 PublicationAdd BLAST281
Alternative sequenceiVSP_028956362 – 686Missing in isoform 4. 1 PublicationAdd BLAST325

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL160398 Genomic DNA No translation available.
AL445309 Genomic DNA No translation available.
BC040876 mRNA Translation: AAH40876.1
BC128580 mRNA Translation: AAI28581.1
BC128581 mRNA Translation: AAI28582.1
AK172770 mRNA Translation: BAD18753.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34331.1 [A1A5C7-2]
CCDS47363.1 [A1A5C7-1]
CCDS75389.1 [A1A5C7-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001273384.1, NM_001286455.1 [A1A5C7-2]
NP_001273385.1, NM_001286456.1 [A1A5C7-4]
NP_056297.1, NM_015482.1 [A1A5C7-1]
NP_068764.3, NM_021945.6 [A1A5C7-2]
XP_016866670.1, XM_017011181.1 [A1A5C7-2]
XP_016866675.1, XM_017011186.1 [A1A5C7-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.713588

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380298; ENSP00000369653; ENSG00000137266 [A1A5C7-4]
ENST00000380302; ENSP00000369657; ENSG00000137266 [A1A5C7-2]
ENST00000406686; ENSP00000385028; ENSG00000137266 [A1A5C7-1]
ENST00000490273; ENSP00000419463; ENSG00000137266 [A1A5C7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
63027

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:63027

UCSC genome browser

More...
UCSCi
uc003mvm.5 human [A1A5C7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160398 Genomic DNA No translation available.
AL445309 Genomic DNA No translation available.
BC040876 mRNA Translation: AAH40876.1
BC128580 mRNA Translation: AAI28581.1
BC128581 mRNA Translation: AAI28582.1
AK172770 mRNA Translation: BAD18753.1 Different initiation.
CCDSiCCDS34331.1 [A1A5C7-2]
CCDS47363.1 [A1A5C7-1]
CCDS75389.1 [A1A5C7-4]
RefSeqiNP_001273384.1, NM_001286455.1 [A1A5C7-2]
NP_001273385.1, NM_001286456.1 [A1A5C7-4]
NP_056297.1, NM_015482.1 [A1A5C7-1]
NP_068764.3, NM_021945.6 [A1A5C7-2]
XP_016866670.1, XM_017011181.1 [A1A5C7-2]
XP_016866675.1, XM_017011186.1 [A1A5C7-2]
UniGeneiHs.713588

3D structure databases

ProteinModelPortaliA1A5C7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121960, 17 interactors
IntActiA1A5C7, 10 interactors
STRINGi9606.ENSP00000385028

Protein family/group databases

TCDBi2.A.1.19.28 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiA1A5C7
PhosphoSitePlusiA1A5C7

Polymorphism and mutation databases

BioMutaiSLC22A23

Proteomic databases

PaxDbiA1A5C7
PRIDEiA1A5C7
ProteomicsDBi113
114 [A1A5C7-2]
115 [A1A5C7-3]
116 [A1A5C7-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380298; ENSP00000369653; ENSG00000137266 [A1A5C7-4]
ENST00000380302; ENSP00000369657; ENSG00000137266 [A1A5C7-2]
ENST00000406686; ENSP00000385028; ENSG00000137266 [A1A5C7-1]
ENST00000490273; ENSP00000419463; ENSG00000137266 [A1A5C7-2]
GeneIDi63027
KEGGihsa:63027
UCSCiuc003mvm.5 human [A1A5C7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63027
DisGeNETi63027
EuPathDBiHostDB:ENSG00000137266.14

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC22A23

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0005541
HIX0005544
HGNCiHGNC:21106 SLC22A23
HPAiHPA014697
MIMi611697 gene
neXtProtiNX_A1A5C7
OpenTargetsiENSG00000137266
PharmGKBiPA162403516

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0255 Eukaryota
ENOG410ZZ6M LUCA
GeneTreeiENSGT00940000157354
HOGENOMiHOG000124569
HOVERGENiHBG108437
InParanoidiA1A5C7
KOiK08215
OrthoDBi292012at2759
PhylomeDBiA1A5C7
TreeFamiTF335753

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC22A23 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
63027

Protein Ontology

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PROi
PR:A1A5C7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000137266 Expressed in 189 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiA1A5C7 baseline and differential
GenevisibleiA1A5C7 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS22AN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1A5C7
Secondary accession number(s): A1A5C8
, Q5T8B8, Q6ZMH3, Q8IW73
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: February 13, 2019
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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