Immunity-related GTPase family M protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• BH3 domain binding Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• CARD domain binding Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• GTPase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• GTP binding Source: UniProtKB-KW
• protein kinase binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• protein serine/threonine kinase activator activity Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M."
    Hansen M.D., Johnsen I.B., Stiberg K.A., Sherstova T., Wakita T., Richard G.M., Kandasamy R.K., Meurs E.F., Anthonsen M.W.
    Proc Natl Acad Sci U S A 114:E3462-E3471(2017) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• autophagosome assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.5

    "Human IRGM induces autophagy to eliminate intracellular mycobacteria."
    Singh S.B., Davis A.S., Taylor G.A., Deretic V.
    Science 313:1438-1441(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• CAMKK-AMPK signaling cascade Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• cellular response to interferon-beta Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to lipopolysaccharide Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• cellular response to virus Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M."
    Hansen M.D., Johnsen I.B., Stiberg K.A., Sherstova T., Wakita T., Richard G.M., Kandasamy R.K., Meurs E.F., Anthonsen M.W.
    Proc Natl Acad Sci U S A 114:E3462-E3471(2017) [PubMed] [Europe PMC] [Abstract]
• defense response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• defense response to bacterium Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.5

    "Human IRGM induces autophagy to eliminate intracellular mycobacteria."
    Singh S.B., Davis A.S., Taylor G.A., Deretic V.
    Science 313:1438-1441(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• defense response to Gram-negative bacterium Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: UniProtKB-KW
• innate immune response Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.5

    "Human IRGM induces autophagy to eliminate intracellular mycobacteria."
    Singh S.B., Davis A.S., Taylor G.A., Deretic V.
    Science 313:1438-1441(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• nucleotide-binding oligomerization domain containing 2 signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation by symbiont of host autophagy Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.5

    "Human IRGM induces autophagy to eliminate intracellular mycobacteria."
    Singh S.B., Davis A.S., Taylor G.A., Deretic V.
    Science 313:1438-1441(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
  • "Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M."
    Hansen M.D., Johnsen I.B., Stiberg K.A., Sherstova T., Wakita T., Richard G.M., Kandasamy R.K., Meurs E.F., Anthonsen M.W.
    Proc Natl Acad Sci U S A 114:E3462-E3471(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of autophagosome maturation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.5

    "Human IRGM induces autophagy to eliminate intracellular mycobacteria."
    Singh S.B., Davis A.S., Taylor G.A., Deretic V.
    Science 313:1438-1441(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• positive regulation of autophagy Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interferon-gamma-mediated signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.5

    "Human IRGM induces autophagy to eliminate intracellular mycobacteria."
    Singh S.B., Davis A.S., Taylor G.A., Deretic V.
    Science 313:1438-1441(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• positive regulation of peptidyl-serine phosphorylation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peptidyl-threonine phosphorylation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M."
    Hansen M.D., Johnsen I.B., Stiberg K.A., Sherstova T., Wakita T., Richard G.M., Kandasamy R.K., Meurs E.F., Anthonsen M.W.
    Proc Natl Acad Sci U S A 114:E3462-E3471(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein serine/threonine kinase activity Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M."
    Hansen M.D., Johnsen I.B., Stiberg K.A., Sherstova T., Wakita T., Richard G.M., Kandasamy R.K., Meurs E.F., Anthonsen M.W.
    Proc Natl Acad Sci U S A 114:E3462-E3471(2017) [PubMed] [Europe PMC] [Abstract]
• protein destabilization Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• protein lipidation involved in autophagosome assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M."
    Hansen M.D., Johnsen I.B., Stiberg K.A., Sherstova T., Wakita T., Richard G.M., Kandasamy R.K., Meurs E.F., Anthonsen M.W.
    Proc Natl Acad Sci U S A 114:E3462-E3471(2017) [PubMed] [Europe PMC] [Abstract]
• protein stabilization Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• regulation of protein complex stability Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• regulation of protein-containing complex assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• BH3 domain binding Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• CARD domain binding Source: UniProtKBInferred from mutant phenotypeⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • "IRGM governs the core autophagy machinery to conduct antimicrobial defense."
    Chauhan S., Mandell M.A., Deretic V.
    Mol Cell 58:507-521(2015) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MEAMNVEKAS ADGNLPEVIS NIKETLKIVS RTPVNITMAG DSGNGMSTFI 
        60         70         80         90        100
SALRNTGHEG KASPPTELVK ATQRCASYFS SHFSNVVLWD LPGTGSATTT 
       110        120        130        140        150
LENYLMEMQF NRYDFIMVAS AQFSMNHVML AKTAEDMGKK FYIVWTKLDM 
       160        170        180 
DLSTGALPEV QLLQIRENVL ENLQKERVCE Y                     

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 5
   Human chromosome 5: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. SIMILARITY comments
   Index of protein domains and families