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Protein

Prefoldin subunit 2

Gene

PFDN2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 2
Gene namesi
Name:PFDN2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828571 – 154Prefoldin subunit 2Add BLAST154

Proteomic databases

PaxDbiA1A4P5
PeptideAtlasiA1A4P5
PRIDEiA1A4P5

Expressioni

Gene expression databases

BgeeiENSBTAG00000020152

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to c-Myc; interacts with its N-terminal domain. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026841

Structurei

3D structure databases

ProteinModelPortaliA1A4P5
SMRiA1A4P5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiKOG4098 Eukaryota
ENOG4111S6I LUCA
GeneTreeiENSGT00390000009272
HOGENOMiHOG000211843
HOVERGENiHBG008172
InParanoidiA1A4P5
KOiK09549
OMAiDPERKCF
OrthoDBiEOG091G11OU
TreeFamiTF313252

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR027235 PFD2
IPR002777 PFD_beta-like
IPR009053 Prefoldin
PANTHERiPTHR13303 PTHR13303, 1 hit
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1A4P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENGGRAGK SSGSGTGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME
60 70 80 90 100
LNEHSLVIDT LKEVDETRKC YRMVGGVLVE RTVKEVLPAL ENNKEQIQKI
110 120 130 140 150
IETLTQQLQA KGKELNEFRE KHNIRLMGED EKPAAKENSE GAGAKASSAG

VLVS
Length:154
Mass (Da):16,648
Last modified:January 23, 2007 - v1
Checksum:i95933161C41BBA16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126786 mRNA Translation: AAI26787.1
RefSeqiNP_001073690.1, NM_001080221.2
UniGeneiBt.1544

Genome annotation databases

EnsembliENSBTAT00000026841; ENSBTAP00000026841; ENSBTAG00000020152
GeneIDi404138
KEGGibta:404138

Similar proteinsi

Entry informationi

Entry nameiPFD2_BOVIN
AccessioniPrimary (citable) accession number: A1A4P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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