UniProtKB - A1A4L6 (ETS2_BOVIN)
Protein
Protein C-ets-2
Gene
ETS2
Organism
Bos taurus (Bovine)
Status
Functioni
Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 364 – 444 | ETSPROSITE-ProRule annotationAdd BLAST | 81 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- cell differentiation Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein C-ets-2 |
Gene namesi | Name:ETS2 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:28627, ETS2 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287131 | 1 – 470 | Protein C-ets-2Add BLAST | 470 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 225 | PhosphoserineBy similarity | 1 | |
Modified residuei | 296 | PhosphoserineBy similarity | 1 | |
Modified residuei | 299 | PhosphoserineBy similarity | 1 | |
Modified residuei | 302 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylation by CDK10 at Ser-225 may create a phosphodegron that targets ETS2 for proteasomal degradation.
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | A1A4L6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 85 – 170 | PNTPROSITE-ProRule annotationAdd BLAST | 86 |
Sequence similaritiesi
Belongs to the ETS family.Curated
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000160202 |
InParanoidi | A1A4L6 |
OrthoDBi | 526256at2759 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR016311, Transform_prot_C-ets IPR027276, Transform_prot_C-ets-2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PIRSFi | PIRSF501032, C-ets-2, 1 hit PIRSF001698, Transforming_factor_C-ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
i Sequence
Sequence statusi: Complete.
A1A4L6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNDFGIKNMD QVAPVASSYR GTLKRQAAFD TFDGSLLAVF PSLNEEQTLQ
60 70 80 90 100
EVPTGLDSIS HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP
110 120 130 140 150
KNPWLWTEQQ VCQWLLWATN EFSLVDVNLQ RFGMTGQVLC NLGKERFLEL
160 170 180 190 200
APDFVGDILW EHLEQMIKEN QEKNEDQYEE NSHLNSVPHW INSNSLGFGV
210 220 230 240 250
EQAPYGMQTQ SYPKGGLLDG LCPASSAPST LGPEQDFQMF PKARLNTVSV
260 270 280 290 300
NYCSVGQDFP AGSLNLLSSA SGKPRDHDSA ETGGDSFESS ESLLQSWNSQ
310 320 330 340 350
SSLLDVQRVP SFESFEDDCS QSLGLSKPTM SFKDYIQDRS DPVEQGKPVI
360 370 380 390 400
PAAVLAGFTG SGPIQLWQFL LELLSDKSCQ SFISWTGDGW EFKLADPDEV
410 420 430 440 450
ARRWGKRKNK PKMNYEKLSR GLRYYYDKNI IHKTSGKRYV YRFVCDLQNL
460 470
LGFTPEELHA ILGVQPDTED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126692 mRNA Translation: AAI26693.1 |
RefSeqi | NP_001073683.1, NM_001080214.1 |
Genome annotation databases
Ensembli | ENSBTAT00000012144; ENSBTAP00000012144; ENSBTAG00000009214 ENSBTAT00000074510; ENSBTAP00000072496; ENSBTAG00000009214 |
GeneIDi | 281148 |
KEGGi | bta:281148 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126692 mRNA Translation: AAI26693.1 |
RefSeqi | NP_001073683.1, NM_001080214.1 |
3D structure databases
SMRi | A1A4L6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000012144 |
Proteomic databases
PaxDbi | A1A4L6 |
Genome annotation databases
Ensembli | ENSBTAT00000012144; ENSBTAP00000012144; ENSBTAG00000009214 ENSBTAT00000074510; ENSBTAP00000072496; ENSBTAG00000009214 |
GeneIDi | 281148 |
KEGGi | bta:281148 |
Organism-specific databases
CTDi | 2114 |
VGNCi | VGNC:28627, ETS2 |
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000160202 |
InParanoidi | A1A4L6 |
OrthoDBi | 526256at2759 |
Gene expression databases
ExpressionAtlasi | A1A4L6, baseline and differential |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR016311, Transform_prot_C-ets IPR027276, Transform_prot_C-ets-2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PIRSFi | PIRSF501032, C-ets-2, 1 hit PIRSF001698, Transforming_factor_C-ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ETS2_BOVIN | |
Accessioni | A1A4L6Primary (citable) accession number: A1A4L6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families