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Protein

Protein C-ets-2

Gene

ETS2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi364 – 444ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C-ets-2
Gene namesi
Name:ETS2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871311 – 470Protein C-ets-2Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei225PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei302PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation by CDK10 at Ser-225 may create a phosphodegron that targets ETS2 for proteasomal degradation.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1A4L6
PRIDEiA1A4L6

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012144

Structurei

3D structure databases

ProteinModelPortaliA1A4L6
SMRiA1A4L6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 170PNTPROSITE-ProRule annotationAdd BLAST86

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
HOGENOMiHOG000285953
HOVERGENiHBG003088
InParanoidiA1A4L6
KOiK21932

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR016311 Transform_prot_C-ets
IPR027276 Transform_prot_C-ets-2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PIRSFiPIRSF501032 C-ets-2, 1 hit
PIRSF001698 Transforming_factor_C-ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

A1A4L6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDFGIKNMD QVAPVASSYR GTLKRQAAFD TFDGSLLAVF PSLNEEQTLQ
60 70 80 90 100
EVPTGLDSIS HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP
110 120 130 140 150
KNPWLWTEQQ VCQWLLWATN EFSLVDVNLQ RFGMTGQVLC NLGKERFLEL
160 170 180 190 200
APDFVGDILW EHLEQMIKEN QEKNEDQYEE NSHLNSVPHW INSNSLGFGV
210 220 230 240 250
EQAPYGMQTQ SYPKGGLLDG LCPASSAPST LGPEQDFQMF PKARLNTVSV
260 270 280 290 300
NYCSVGQDFP AGSLNLLSSA SGKPRDHDSA ETGGDSFESS ESLLQSWNSQ
310 320 330 340 350
SSLLDVQRVP SFESFEDDCS QSLGLSKPTM SFKDYIQDRS DPVEQGKPVI
360 370 380 390 400
PAAVLAGFTG SGPIQLWQFL LELLSDKSCQ SFISWTGDGW EFKLADPDEV
410 420 430 440 450
ARRWGKRKNK PKMNYEKLSR GLRYYYDKNI IHKTSGKRYV YRFVCDLQNL
460 470
LGFTPEELHA ILGVQPDTED
Length:470
Mass (Da):52,654
Last modified:January 23, 2007 - v1
Checksum:iA0F1364B8DACC6AA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1MEX1F1MEX1_BOVIN
Protein C-ets-2
ETS2
448Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126692 mRNA Translation: AAI26693.1
RefSeqiNP_001073683.1, NM_001080214.1
UniGeneiBt.103933
Bt.5774

Genome annotation databases

GeneIDi281148
KEGGibta:281148

Similar proteinsi

Entry informationi

Entry nameiETS2_BOVIN
AccessioniPrimary (citable) accession number: A1A4L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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