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Entry version 77 (13 Feb 2019)
Sequence version 1 (23 Jan 2007)
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Protein

Leukemia NUP98 fusion partner 1

Gene

LNP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukemia NUP98 fusion partner 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LNP1
Synonyms:NP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000206535.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28014 LNP1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A1A4G5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving LNP1 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with NUP98.1 Publication

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000206535

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671542

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LNP1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003413571 – 178Leukemia NUP98 fusion partner 1Add BLAST178

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A1A4G5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1A4G5

PRoteomics IDEntifications database

More...
PRIDEi
A1A4G5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
91

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1A4G5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A1A4G5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000206535 Expressed in 177 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1A4G5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1A4G5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047926

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131532, 20 interactors

Protein interaction database and analysis system

More...
IntActi
A1A4G5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373191

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A1A4G5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5 – 10Poly-Asp6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J1GM Eukaryota
ENOG410Z4TY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007797

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG101586

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1A4G5

Database of Orthologous Groups

More...
OrthoDBi
1320740at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1A4G5

TreeFam database of animal gene trees

More...
TreeFami
TF342726

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029280 LNP1

The PANTHER Classification System

More...
PANTHERi
PTHR35667 PTHR35667, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15419 LNP1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A1A4G5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHKDDDDDD VSFAKWMSSF WGHSWREEDQ RGLRERHRLQ ATSHRKTSLP
60 70 80 90 100
CPLPVLPRIP SSDCHPRRHS HEDQEFRCRS HVRDYRKYSE DGSFKEPLES
110 120 130 140 150
KGRSHSKIEK FSESFERQLC FRTKRSASLG PESRKERNER ECLRMEIKSR
160 170
KKVEEERSSR KEEHGEAHMA PLFEKGPE
Length:178
Mass (Da):21,321
Last modified:January 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA51126C819511E23
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J587C9J587_HUMAN
Leukemia NUP98 fusion partner 1
LNP1
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF60F8WF60_HUMAN
Leukemia NUP98 fusion partner 1
LNP1
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC126362 mRNA Translation: AAI26363.1
BC130480 mRNA Translation: AAI30481.1
BC144031 mRNA Translation: AAI44032.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43120.1

NCBI Reference Sequences

More...
RefSeqi
NP_001078920.1, NM_001085451.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.591294

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000383693; ENSP00000373191; ENSG00000206535

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
348801

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:348801

UCSC genome browser

More...
UCSCi
uc003dtx.5 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126362 mRNA Translation: AAI26363.1
BC130480 mRNA Translation: AAI30481.1
BC144031 mRNA Translation: AAI44032.1
CCDSiCCDS43120.1
RefSeqiNP_001078920.1, NM_001085451.1
UniGeneiHs.591294

3D structure databases

ProteinModelPortaliA1A4G5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131532, 20 interactors
IntActiA1A4G5, 1 interactor
STRINGi9606.ENSP00000373191

PTM databases

iPTMnetiA1A4G5
PhosphoSitePlusiA1A4G5

Polymorphism and mutation databases

BioMutaiLNP1

Proteomic databases

MaxQBiA1A4G5
PaxDbiA1A4G5
PRIDEiA1A4G5
ProteomicsDBi91

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
348801
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383693; ENSP00000373191; ENSG00000206535
GeneIDi348801
KEGGihsa:348801
UCSCiuc003dtx.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
348801
EuPathDBiHostDB:ENSG00000206535.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LNP1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0021851
HGNCiHGNC:28014 LNP1
HPAiHPA047926
neXtProtiNX_A1A4G5
OpenTargetsiENSG00000206535
PharmGKBiPA142671542

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J1GM Eukaryota
ENOG410Z4TY LUCA
GeneTreeiENSGT00390000007797
HOVERGENiHBG101586
InParanoidiA1A4G5
OrthoDBi1320740at2759
PhylomeDBiA1A4G5
TreeFamiTF342726

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LNP1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
348801

Protein Ontology

More...
PROi
PR:A1A4G5

Gene expression databases

BgeeiENSG00000206535 Expressed in 177 organ(s), highest expression level in testis
ExpressionAtlasiA1A4G5 baseline and differential
GenevisibleiA1A4G5 HS

Family and domain databases

InterProiView protein in InterPro
IPR029280 LNP1
PANTHERiPTHR35667 PTHR35667, 1 hit
PfamiView protein in Pfam
PF15419 LNP1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLNP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1A4G5
Secondary accession number(s): B7ZLT3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 23, 2007
Last modified: February 13, 2019
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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