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UniProtKB - A1A4E9 (A1A4E9_HUMAN)
Protein
Submitted name:
Keratin 13
Gene
KRT13
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Keratin 13ImportedSubmitted name: Keratin 13, isoform CRA_aImported |
Gene namesi | Name:KRT13Imported ORF Names:hCG_1730613Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
Keywords - Cellular componenti
Intermediate filamentUniRule annotationARBA annotation, KeratinImportedStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 104 – 416 | IF rodInterPro annotationAdd BLAST | 313 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 420 – 458 | DisorderedSequence analysisAdd BLAST | 39 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 108 – 142 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 208 – 253 | Sequence analysisAdd BLAST | 46 | |
Coiled coili | 274 – 294 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 314 – 348 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 360 – 401 | Sequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 423 – 451 | Polar residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the intermediate filament family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
OrthoDBi | 798081at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A1A4E9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLRLQSSSA SYGGGFGGGS CQLGGGRGVS TCSTRFVSGG SAGGYGGGVS
60 70 80 90 100
CGFGGGAGSG FGGGYGGGLG GGYGGGLGGG FGGGFAGGFV DFGACDGGLL
110 120 130 140 150
TGNEKITMQN LNDRLASYLE KVRALEEANA DLEVKIRDWH LKQSPASPER
160 170 180 190 200
DYSPYYKTIE ELRDKILTAT IENNRVILEI DNARLAVDDF RLKYENELAL
210 220 230 240 250
RQSVEADING LRRVLDELTL SKTDLEMQIE SLNEELAYMK KNHEEEMKEF
260 270 280 290 300
SNQVVGQVNV EMDATPGIDL TRVLAEMREQ YEAMAERNRR DAEEWFHAKS
310 320 330 340 350
AELNKEVSTN TAMIQTSKTE ITELRRTLQG LEIELQSQLS MKAGLENTVA
360 370 380 390 400
ETECRYALQL QQIQGLISSI EAQLSELRSE MECQNQEYKM LLDIKTRLEQ
410 420 430 440 450
EIATYRSLLE GQDAKMIGFP SSAGSVSPRS TSVTTTSSAS VTTTSNASGR
RTSDVRRP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126184 mRNA Translation: AAI26185.1 BC136494 mRNA Translation: AAI36495.1 CH471152 Genomic DNA Translation: EAW60740.1 |
RefSeqi | NP_705694.2, NM_153490.2 |
Genome annotation databases
GeneIDi | 3860 |
KEGGi | hsa:3860 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC126184 mRNA Translation: AAI26185.1 BC136494 mRNA Translation: AAI36495.1 CH471152 Genomic DNA Translation: EAW60740.1 |
RefSeqi | NP_705694.2, NM_153490.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A1A4E9, 44 interactors |
Protocols and materials databases
DNASUi | 3860 |
Genome annotation databases
GeneIDi | 3860 |
KEGGi | hsa:3860 |
Organism-specific databases
CTDi | 3860 |
PharmGKBi | PA30202 |
Phylogenomic databases
OrthoDBi | 798081at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3860, 12 hits in 1069 CRISPR screens |
ChiTaRSi | KRT13, human |
GenomeRNAii | 3860 |
Family and domain databases
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A1A4E9_HUMAN | |
Accessioni | A1A4E9Primary (citable) accession number: A1A4E9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 23, 2007 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |