UniProtKB - A0ZSE6 (CC50C_HUMAN)
Protein
Cell cycle control protein 50C
Gene
TMEM30CP
Organism
Homo sapiens (Human)
Status
Functioni
Caution
According to PubMed:17258408, the major transcript has no stop-codon and is probably non protein-coding. A minor transcript is also expressed and encodes the displayed protein which misses C-terminal part compared to other mammalian orthologs.Curated
GO - Biological processi
- phospholipid translocation Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Cell cycle control protein 50CAlternative name(s): Transmembrane protein 30C |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30443, TMEM30CP |
MIMi | 611030, gene |
neXtProti | NX_A0ZSE6 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 34 | CytoplasmicSequence analysisAdd BLAST | 34 | |
Transmembranei | 35 – 55 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 56 – 113 | ExtracellularSequence analysisAdd BLAST | 58 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Miscellaneous databases
Pharosi | A0ZSE6, Tdark |
Genetic variation databases
BioMutai | HGNC:30443 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000292845 | 1 – 113 | Cell cycle control protein 50CAdd BLAST | 113 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 66 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | A0ZSE6 |
PRIDEi | A0ZSE6 |
ProteomicsDBi | 87 |
PTM databases
GlyGeni | A0ZSE6, 1 site |
Expressioni
Tissue specificityi
Specifically expressed in testis.1 Publication
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000419663 |
Miscellaneous databases
RNActi | A0ZSE6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the CDC50/LEM3 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2952, Eukaryota |
InParanoidi | A0ZSE6 |
PhylomeDBi | A0ZSE6 |
Family and domain databases
InterProi | View protein in InterPro IPR005045, CDC50/LEM3_fam IPR030353, TMEM30C |
PANTHERi | PTHR10926, PTHR10926, 1 hit PTHR10926:SF54, PTHR10926:SF54, 1 hit |
i Sequence
Sequence statusi: Complete.
A0ZSE6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEERAQHCLS RLLDNSALKQ QELPIHRLYF TARRVLFVFF ATGIFCLCMG
60 70 80 90 100
IILILSARST QEIEINYTRI CANCAKLREN ASNFDKECTC SIPFYLSGKM
110
MVGEIQETRL TLH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC129803 Genomic DNA No translation available. AB250297 mRNA Translation: BAF41210.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC129803 Genomic DNA No translation available. AB250297 mRNA Translation: BAF41210.1 |
3D structure databases
SMRi | A0ZSE6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000419663 |
PTM databases
GlyGeni | A0ZSE6, 1 site |
Genetic variation databases
BioMutai | HGNC:30443 |
Proteomic databases
PaxDbi | A0ZSE6 |
PRIDEi | A0ZSE6 |
ProteomicsDBi | 87 |
Organism-specific databases
GeneCardsi | TMEM30CP |
HGNCi | HGNC:30443, TMEM30CP |
MIMi | 611030, gene |
neXtProti | NX_A0ZSE6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2952, Eukaryota |
InParanoidi | A0ZSE6 |
PhylomeDBi | A0ZSE6 |
Miscellaneous databases
Pharosi | A0ZSE6, Tdark |
PROi | PR:A0ZSE6 |
RNActi | A0ZSE6, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR005045, CDC50/LEM3_fam IPR030353, TMEM30C |
PANTHERi | PTHR10926, PTHR10926, 1 hit PTHR10926:SF54, PTHR10926:SF54, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CC50C_HUMAN | |
Accessioni | A0ZSE6Primary (citable) accession number: A0ZSE6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | June 26, 2007 | |
Last modified: | February 10, 2021 | |
This is version 83 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families