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Protein
Submitted name:

LIM domain only 7

Gene

Lmo7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LIM domain only 7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lmo7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1353586 Lmo7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0T1J8

PRoteomics IDEntifications database

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PRIDEi
A0T1J8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A0T1J8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A0T1J8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A0T1J8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A0T1J8, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A0T1J8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 129Calponin-homology (CH)InterPro annotationAdd BLAST118
Domaini1036 – 1091PDZInterPro annotationAdd BLAST56
Domaini1628 – 1694LIM zinc-bindingInterPro annotationAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili669 – 724Sequence analysisAdd BLAST56
Coiled coili1221 – 1271Sequence analysisAdd BLAST51
Coiled coili1325 – 1366Sequence analysisAdd BLAST42
Coiled coili1374 – 1410Sequence analysisAdd BLAST37

Keywords - Domaini

Coiled coilSequence analysis, LIM domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1704 Eukaryota
ENOG410ZBDQ LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043081

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG049143

Database of Orthologous Groups

More...
OrthoDBi
38375at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR031865 DUF4757
IPR029978 LMO-7
IPR001478 PDZ
IPR036034 PDZ_sf
IPR003096 SM22_calponin
IPR001781 Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR15551:SF4 PTHR15551:SF4, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF15949 DUF4757, 2 hits
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00888 SM22CALPONIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0T1J8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGMEDAEAD CSVAFAEAQR WVEAVTEKNF ETTDFRASLE NGVLLCDLIN
60 70 80 90 100
KLKPGVVKKI NRLSTPIAGL DNINVFLRAC EQIGLKEAQL FHPGDLQDLS
110 120 130 140 150
NRVTVKQEET DRRLKNVLIT LYWLGRKAQS NPYYNGPYLN LKAFETLLGQ
160 170 180 190 200
ALTKALEDSS CLKRSGRDSG YGDIWCPDRG EFPAPPGSHR REDSFESLDS
210 220 230 240 250
LGSRSLTSCS SDFTLRVGKE GCESDIDWEF TFKMQDYNKD DMSYRRISAI
260 270 280 290 300
EPKSALPFNR FLPNKSKQPS YVPAPFEKKR PDKHEDNRRS WASPVYTETD
310 320 330 340 350
GTFSSTQRRT WGPKMETWHT VQETSTSSWC VEEEEEKLTR MPNIVKDDLY
360 370 380 390 400
VRKLSPVMPS PGSSFDQFLP KCWTPEDMNW KKIKRETYKP WYKEFQGFSQ
410 420 430 440 450
FLLLQALQTY SDDILSSETS VKLDPTSGPR LITRRKNRSP APGYRAHDLE
460 470 480 490 500
LPALDPDLEN DDFFVRKTGA FHANPCVLRA FEDFRSFSEP DDAVERDIIL
510 520 530 540 550
QCREGELVLP DLEKDDMIVR RIPAQKKEVP LSGAPDRYQP VPFPEPWTLP
560 570 580 590 600
PEIQAKFLSV LERTRPPKEQ SSGCRVLVPS YRQKKDDMLA RKIQSWKLGT
610 620 630 640 650
AVPPISFKPG PCSEADLQKW EAIWEASRLR HRKRLMVERL FQKIYGENGS
660 670 680 690 700
KSMSDVSAED VQNLRQVRYE EMQKIKSQLK EQDQKWQDDL AKWKNRRKSY
710 720 730 740 750
TSDLQKKKEE REEIEKQALE KSDRSSKTFR EMLQDRESRG STVTSWRRTY
760 770 780 790 800
SSDDILDDGV LPPTVTLSET SYQSERLEDE ARAHPAEMPK EDSTTFANRE
810 820 830 840 850
DSVVAETQLA SHSPEEQRLA PSPSEEPRQA SGSSAEPHQA PLLSTEPRRT
860 870 880 890 900
PLPSEEPHQA SLSSTLQRPS SLSSQQSWST RAESTRISAS LPRSYQRTDT
910 920 930 940 950
ARLTSVVTAR PFGTSSRGIS SLPRSYTMDD GWKYNGDVEV VKREQLDLGR
960 970 980 990 1000
ATGPKPDSSH FISGSASEKE VIATEDVASL SSPTLPSSSL SHDRAVSSKA
1010 1020 1030 1040 1050
TFSSMSGLDS VSDSGEGRGS PLREVSRSLD QFSDMRVSIN QTPGNKPVFG
1060 1070 1080 1090 1100
FTIKWDISGI FVASVEQGSP AEFSQLQVDD EILAINNTKF SYKDTKKWEE
1110 1120 1130 1140 1150
VMANAQETGN LVMDVRRYGK SGSSETKWID TTSGIYNSDK SSSLSVTTDF
1160 1170 1180 1190 1200
SESLQSPYTE SKEVNGIHEE SNPFDSKASE SISLKNLKRR SQFFEQGSSD
1210 1220 1230 1240 1250
SVAPDLPVPT LSAPSRWAWD QEEERRRQER WQKEQDRLLQ EKYQREQEKL
1260 1270 1280 1290 1300
REEWQRAQQE AERENSKYLD EELMVLNSNS ISLTSREPVA ATWEATWSEG
1310 1320 1330 1340 1350
SKSLDSEGTR AGEEDRGQLE DDAVYEDQSQ KLQELEQEKK RKEQEAQEEE
1360 1370 1380 1390 1400
RRKQREAQAW AEAEAKAWAE AQARAEAEAK ARAEAQARAE AEAQKRAEAQ
1410 1420 1430 1440 1450
KLQAERERET SVKIYQYRRP IDSYDLPKRE DDTSGMLPTD RSKSRSTTEL
1460 1470 1480 1490 1500
NDPLIEKNGS SKYSERIGAT SFSHRSSKKD QAPSEAELER QQILQEMRKR
1510 1520 1530 1540 1550
TSLHNDNSWI RQRSASVNKE PICLPGIMRR GESLDNLDSQ RPGSWRQSPW
1560 1570 1580 1590 1600
HSQPAGVYAS SSVQDFSRPP PQLLSTSNRA YMRNPSSAVP PPAGSVKTSP
1610 1620 1630 1640 1650
GSPSPRSHSP SMSQSGSQLR NRSVSGKRVC SYCNNILGKG AAMIIETLGL
1660 1670 1680 1690
SYHLHCFKCV SCGCDLGGSS SGAEVRIRNH QLYCNDCYLR FKSGRPTAM
Length:1,699
Mass (Da):192,560
Last modified:January 9, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB35C5A303632E7AD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF071857 mRNA Translation: ABK60217.1

NCBI Reference Sequences

More...
RefSeqi
NP_963287.2, NM_201529.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.218981

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
380928

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF071857 mRNA Translation: ABK60217.1
RefSeqiNP_963287.2, NM_201529.2
UniGeneiMm.218981

3D structure databases

ProteinModelPortaliA0T1J8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA0T1J8, 2 interactors

PTM databases

iPTMnetiA0T1J8
PhosphoSitePlusiA0T1J8

Proteomic databases

PeptideAtlasiA0T1J8
PRIDEiA0T1J8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi380928

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4008
MGIiMGI:1353586 Lmo7

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410ZBDQ LUCA
HOGENOMiHOG000043081
HOVERGENiHBG049143
OrthoDBi38375at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lmo7 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiA0T1J8 MM

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR031865 DUF4757
IPR029978 LMO-7
IPR001478 PDZ
IPR036034 PDZ_sf
IPR003096 SM22_calponin
IPR001781 Znf_LIM
PANTHERiPTHR15551:SF4 PTHR15551:SF4, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF15949 DUF4757, 2 hits
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0T1J8_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0T1J8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: January 16, 2019
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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