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Protein

Alpha-conotoxin-like Pu1.1

Gene
N/A
Organism
Conus pulicarius (Flea-bite cone)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin-like Pu1.1
OrganismiConus pulicarius (Flea-bite cone)
Taxonomic identifieri93154 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri542 Pu1.1 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000037068022 – 46By similarityAdd BLAST25
PeptideiPRO_000037068147 – 63Alpha-conotoxin-like Pu1.1Add BLAST17

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi49 ↔ 55By similarity
Disulfide bondi50 ↔ 63By similarity
Modified residuei63Cysteine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.Curated

Structurei

3D structure databases

ProteinModelPortaliA0SE60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.Curated

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0SE60-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMRMMFTVF LLVVLATTVV SFTSDRTSDG RNAAFNAFDL IALTARQNCC
60
NVPGCWAKYK HLCGRKR
Length:67
Mass (Da):7,507
Last modified:January 9, 2007 - v1
Checksum:iBE6CE72F20754F7C
GO

Sequence cautioni

The sequence ABD48793 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ309775 Genomic DNA Translation: ABC39768.1
DQ359142 Genomic DNA Translation: ABD48793.1 Different initiation.

Similar proteinsi

Entry informationi

Entry nameiCA11_CONPL
AccessioniPrimary (citable) accession number: A0SE60
Secondary accession number(s): A6M936
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 9, 2007
Last modified: September 12, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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