UniProtKB - A0SA68 (A0SA68_HUMAN)
Protein
NADH-ubiquinone oxidoreductase chain 4
Gene
ND4
Organism
Homo sapiens (Human)
Status
Functioni
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.UniRule annotation
Catalytic activityi
- EC:7.1.1.2UniRule annotation
GO - Molecular functioni
- NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-UniRule
GO - Biological processi
- mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Keywordsi
Molecular function | TranslocaseSAAS annotation |
Biological process | Electron transport, Respiratory chainUniRule annotation, Transport |
Ligand | NADUniRule annotationSAAS annotation, UbiquinoneUniRule annotationSAAS annotation |
Names & Taxonomyi
Protein namesi | Recommended name: NADH-ubiquinone oxidoreductase chain 4UniRule annotation (EC:7.1.1.2UniRule annotation) |
Gene namesi | Name:ND4Imported |
Encoded oni | MitochondrionImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- respirasome Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 21 – 41 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 148 – 167 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 196 – 216 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 223 – 244 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 256 – 277 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 284 – 303 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 309 – 330 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 351 – 369 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 389 – 409 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, MitochondrionUniRule annotationImportedFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 109 | Oxidored_q5_NInterPro annotationAdd BLAST | 109 | |
Domaini | 112 – 398 | Proton_antipo_MInterPro annotationAdd BLAST | 287 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationSAAS annotationPhylogenomic databases
eggNOGi | KOG4845 Eukaryota COG1008 LUCA |
Family and domain databases
InterProi | View protein in InterPro IPR000260 NADH4_N IPR010227 NADH_Q_OxRdtase_chainM/4 IPR003918 NADH_UbQ_OxRdtase IPR001750 ND/Mrp_mem |
PANTHERi | PTHR43507 PTHR43507, 1 hit |
Pfami | View protein in Pfam PF01059 Oxidored_q5_N, 1 hit PF00361 Proton_antipo_M, 1 hit |
PRINTSi | PR01437 NUOXDRDTASE4 |
TIGRFAMsi | TIGR01972 NDH_I_M, 1 hit |
i Sequence
Sequence statusi: Complete.
A0SA68-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKLIVPTIM LLPLTWLSKK HMIWINTTTH SLIISIIPLL FFNQINNNLF
60 70 80 90 100
SCSPTFSSDP LTTPLLMLTT WLLPLTIMAS QRHLSSEPLS RKKLYLSMLI
110 120 130 140 150
SLQISLIMTF TATELIMFYI FFETTLIPTL AIITRWGNQP ERLNAGTYFL
160 170 180 190 200
FYTLVGSLPL LIALIYTHNT LGSLNILLLT LTAQELSNSW ANNLMWLAYT
210 220 230 240 250
MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG YGMMRLTLIL
260 270 280 290 300
NPLTKHMAYP FLVLSLWGMI MTSSICLRQT DLKSLIAYSS ISHMALVVTA
310 320 330 340 350
ILIQTPWSFT GAVILMVAHG LTSSLLFCLA NSNYERTHSR IMILSQGLQT
360 370 380 390 400
LLPLMAFWWL LASLANLALP PTINLLGELS VLVTTFSWSN ITLLLTGLNM
410 420 430 440 450
LVTALYSLYM FTTTQWGSLT HHINNMKPSF TRENTLMFMH LSPILLLSLN
PDIITGFSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ304950 Genomic DNA Translation: ABB98253.1 GQ119012 Genomic DNA Translation: ACS48632.1 GQ301875 Genomic DNA Translation: ACT15798.1 JQ045124 Genomic DNA Translation: AEV51188.1 JQ705469 Genomic DNA Translation: AFG09064.1 JQ798098 Genomic DNA Translation: AFI54031.1 KC505111 Genomic DNA Translation: AGI50120.1 KF451431 Genomic DNA Translation: AGZ72245.1 KJ446755 Genomic DNA Translation: AHX55878.1 KP345977 Genomic DNA Translation: AKB99434.1 KT587538 Genomic DNA Translation: AMZ82796.1 KT587647 Genomic DNA Translation: AMZ84213.1 MG272730 Genomic DNA Translation: AVL86919.1 MH449515 Genomic DNA Translation: AYW11412.1 MH449549 Genomic DNA Translation: AYW11854.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ304950 Genomic DNA Translation: ABB98253.1 GQ119012 Genomic DNA Translation: ACS48632.1 GQ301875 Genomic DNA Translation: ACT15798.1 JQ045124 Genomic DNA Translation: AEV51188.1 JQ705469 Genomic DNA Translation: AFG09064.1 JQ798098 Genomic DNA Translation: AFI54031.1 KC505111 Genomic DNA Translation: AGI50120.1 KF451431 Genomic DNA Translation: AGZ72245.1 KJ446755 Genomic DNA Translation: AHX55878.1 KP345977 Genomic DNA Translation: AKB99434.1 KT587538 Genomic DNA Translation: AMZ82796.1 KT587647 Genomic DNA Translation: AMZ84213.1 MG272730 Genomic DNA Translation: AVL86919.1 MH449515 Genomic DNA Translation: AYW11412.1 MH449549 Genomic DNA Translation: AYW11854.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | A0SA68 |
Phylogenomic databases
eggNOGi | KOG4845 Eukaryota COG1008 LUCA |
Miscellaneous databases
ChiTaRSi | ND4 human |
Family and domain databases
InterProi | View protein in InterPro IPR000260 NADH4_N IPR010227 NADH_Q_OxRdtase_chainM/4 IPR003918 NADH_UbQ_OxRdtase IPR001750 ND/Mrp_mem |
PANTHERi | PTHR43507 PTHR43507, 1 hit |
Pfami | View protein in Pfam PF01059 Oxidored_q5_N, 1 hit PF00361 Proton_antipo_M, 1 hit |
PRINTSi | PR01437 NUOXDRDTASE4 |
TIGRFAMsi | TIGR01972 NDH_I_M, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0SA68_HUMAN | |
Accessioni | A0SA68Primary (citable) accession number: A0SA68 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 9, 2007 |
Last sequence update: | January 9, 2007 | |
Last modified: | September 18, 2019 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |