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Entry version 129 (10 Feb 2021)
Sequence version 1 (09 Jan 2007)
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Protein

Chitinase

Gene

Chit1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.ARBA annotation EC:3.2.1.14

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseARBA annotation, Hydrolase
Biological processCarbohydrate metabolismARBA annotation
LigandChitin-bindingARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-189085, Digestion of dietary carbohydrate
R-RNO-6798695, Neutrophil degranulation

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM14, Carbohydrate-Binding Module Family 14
GH18, Glycoside Hydrolase Family 18

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ChitinaseARBA annotation (EC:3.2.1.14ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Chit1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Rat genome database

More...
RGDi
1305646, Chit1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501408328422 – 464ChitinaseSequence analysisAdd BLAST443

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A0S5V8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000028072, Expressed in testis and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000036477

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0S5V8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini415 – 464Chitin-binding type-2InterPro annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni383 – 420DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi393 – 407Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2806, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161149

Identification of Orthologs from Complete Genome Data

More...
OMAi
FYYCSGG

Database of Orthologous Groups

More...
OrthoDBi
1289629at2759

TreeFam database of animal gene trees

More...
TreeFami
TF315610

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002557, Chitin-bd_dom
IPR036508, Chitin-bd_dom_sf
IPR011583, Chitinase_II
IPR029070, Chitinase_insertion_sf
IPR001223, Glyco_hydro18_cat
IPR001579, Glyco_hydro_18_chit_AS
IPR017853, Glycoside_hydrolase_SF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01607, CBM_14, 1 hit
PF00704, Glyco_hydro_18, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00636, Glyco_18, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445, SSF51445, 1 hit
SSF54556, SSF54556, 1 hit
SSF57625, SSF57625, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50940, CHIT_BIND_II, 1 hit
PS01095, GH18_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0S5V8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQSLALAGV TTLLMIQWGS AAKLFCYFTN WAQYRSGAAR FLPRDVDPNL
60 70 80 90 100
CTHVIYAFAG LNNHQVSTVE PNDELFYQEL NSLKKRNPKL KTLLAVGGWS
110 120 130 140 150
FGTQKFTDMV ATASTRQTFV NSALSFLRTH GFDGLDLDWE YPGSRGSPAV
160 170 180 190 200
DKERFTALIQ DLAKAFQEEA RASGKSRLLL TAAVPTGRGH VDAGYEVDKI
210 220 230 240 250
VQSLDFINLM AYDFHSSWDK TTGHNSPLYK RQGETGKDAE KNVDAAVTLW
260 270 280 290 300
LQKGTPASKL MLGMPAYGRS FTLASSSDSG VGAPATGPGA PGPYTKEKGI
310 320 330 340 350
LVYFEVCSWK GKQRIEDQKV PYVSQGNQWV GFDDRESFRA KAAYVKQKGL
360 370 380 390 400
GGAMVWILDG DDFKGSFCNE GQYPLIRTLH QELSLSSGPP RSPEQEVPGP
410 420 430 440 450
HQPSEPEQGP SPGLDDFCQG KADGLYPNPT EKSSFYSCGG GRLFQHSCPP
460
GLVFIDSCKC CTWG
Length:464
Mass (Da):50,782
Last modified:January 9, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5065C1415DB13F9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC117152 Genomic DNA No translation available.
DQ286232 mRNA Translation: ABB89471.1
DQ923316 mRNA Translation: ABL06995.1
DQ923317 mRNA Translation: ABL06996.1
DQ923318 mRNA Translation: ABL06997.1
DQ923319 mRNA Translation: ABL06998.1
DQ923320 mRNA Translation: ABL06999.1

NCBI Reference Sequences

More...
RefSeqi
NP_001073157.1, NM_001079689.2
NP_001257775.1, NM_001270846.1
NP_001257776.1, NM_001270847.1
NP_001257777.1, NM_001270848.1
XP_017454187.1, XM_017598698.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000035658; ENSRNOP00000036477; ENSRNOG00000028072
ENSRNOT00000080768; ENSRNOP00000070204; ENSRNOG00000028072

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
289032

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:289032

UCSC genome browser

More...
UCSCi
RGD:1305646, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117152 Genomic DNA No translation available.
DQ286232 mRNA Translation: ABB89471.1
DQ923316 mRNA Translation: ABL06995.1
DQ923317 mRNA Translation: ABL06996.1
DQ923318 mRNA Translation: ABL06997.1
DQ923319 mRNA Translation: ABL06998.1
DQ923320 mRNA Translation: ABL06999.1
RefSeqiNP_001073157.1, NM_001079689.2
NP_001257775.1, NM_001270846.1
NP_001257776.1, NM_001270847.1
NP_001257777.1, NM_001270848.1
XP_017454187.1, XM_017598698.1

3D structure databases

SMRiA0S5V8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036477

Protein family/group databases

CAZyiCBM14, Carbohydrate-Binding Module Family 14
GH18, Glycoside Hydrolase Family 18

Proteomic databases

PRIDEiA0S5V8

Genome annotation databases

EnsembliENSRNOT00000035658; ENSRNOP00000036477; ENSRNOG00000028072
ENSRNOT00000080768; ENSRNOP00000070204; ENSRNOG00000028072
GeneIDi289032
KEGGirno:289032
UCSCiRGD:1305646, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1118
RGDi1305646, Chit1

Phylogenomic databases

eggNOGiKOG2806, Eukaryota
GeneTreeiENSGT00940000161149
OMAiFYYCSGG
OrthoDBi1289629at2759
TreeFamiTF315610

Enzyme and pathway databases

ReactomeiR-RNO-189085, Digestion of dietary carbohydrate
R-RNO-6798695, Neutrophil degranulation

Gene expression databases

BgeeiENSRNOG00000028072, Expressed in testis and 20 other tissues

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR002557, Chitin-bd_dom
IPR036508, Chitin-bd_dom_sf
IPR011583, Chitinase_II
IPR029070, Chitinase_insertion_sf
IPR001223, Glyco_hydro18_cat
IPR001579, Glyco_hydro_18_chit_AS
IPR017853, Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF01607, CBM_14, 1 hit
PF00704, Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636, Glyco_18, 1 hit
SUPFAMiSSF51445, SSF51445, 1 hit
SSF54556, SSF54556, 1 hit
SSF57625, SSF57625, 1 hit
PROSITEiView protein in PROSITE
PS50940, CHIT_BIND_II, 1 hit
PS01095, GH18_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0S5V8_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0S5V8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: February 10, 2021
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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