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Protein

Argininosuccinate synthase

Gene

argG

Organism
Cenarchaeum symbiosum (strain A)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85CitrullineUniRule annotation1
Binding sitei115ATP; via amide nitrogenUniRule annotation1
Binding sitei121AspartateUniRule annotation1
Binding sitei121CitrullineUniRule annotation1
Binding sitei122AspartateUniRule annotation1
Binding sitei125CitrullineUniRule annotation1
Binding sitei171CitrullineUniRule annotation1
Binding sitei255CitrullineUniRule annotation1
Binding sitei267CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 16ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:CENSYa_0928Imported
OrganismiCenarchaeum symbiosum (strain A)Imported
Taxonomic identifieri414004 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaCenarchaealesCenarchaeaceaeCenarchaeum
Proteomesi
  • UP000000758 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0RW43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit

Sequencei

Sequence statusi: Complete.

A0RW43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGKAVLAFS GGLDTSVVAR MLQDRGMDVV TVTVDVGQGG DYRRVAAKSR
60 70 80 90 100
RLGAVKHRHI DARAEFATRY VIPAIKANAL YQGKYCLATA LARPLIAVKL
110 120 130 140 150
LEVARKEGAK ALAHGCSGKG NDQVRFDNAL RAGGKLPIIA PIRELDLDRP
160 170 180 190 200
AELEYAAEHG IAIDKVAKRY SIDQNLWGRA IEGGDLEDPY SEPRDDAFAW
210 220 230 240 250
VRTRNLPAKP TYIVVRFERG VPVAVDGKRM RPADLVAYMN KKAGAAGVGI
260 270 280 290 300
VDHIEDRVVG IKSREVYETP GALCLIEAHA DLEKMVHTSH QSRFKRSADA
310 320 330 340 350
EWAQLAYTGL WDDPLREDLD SLIESSQSAV TGDVRLRLLQ GGMRVVGRRS
360 370 380 390
PRSLYSRKAA TYGPGSTFDQ RLARGFVELW GMQSAEAARL RDRR
Length:394
Mass (Da):43,302
Last modified:January 9, 2007 - v1
Checksum:iD18BE826F76A6B86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000238 Genomic DNA Translation: ABK77560.1

Genome annotation databases

EnsemblBacteriaiABK77560; ABK77560; CENSYa_0928
KEGGicsy:CENSYa_0928
PATRICifig|414004.10.peg.857

Similar proteinsi

Entry informationi

Entry nameiA0RW43_CENSY
AccessioniPrimary (citable) accession number: A0RW43
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: February 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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