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Protein

ADP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

nnrD

Organism
Cenarchaeum symbiosum (strain A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide = AMP + phosphate + NADH.UniRule annotation
ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide phosphate = AMP + phosphate + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei111NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei225NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi196 – 200ADPUniRule annotation5
Nucleotide bindingi215 – 224ADPUniRule annotation10

GO - Molecular functioni

Keywordsi

Molecular functionLyase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.136UniRule annotation)
Alternative name(s):
ADP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
Name:nnrDUniRule annotation
Ordered Locus Names:CENSYa_0257
OrganismiCenarchaeum symbiosum (strain A)
Taxonomic identifieri414004 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaCenarchaealesCenarchaeaceaeCenarchaeum
Proteomesi
  • UP000000758 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004161521 – 287ADP-dependent (S)-NAD(P)H-hydrate dehydrataseAdd BLAST287

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

SMRiA0RU82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 283YjeF C-terminalUniRule annotationAdd BLAST277

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni159 – 165NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000105660
KOiK17758

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

A0RU82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARMIGEDD VRKFVPSRRR DSRKGENGKV LVVGGSYIYH GAPIFSSVAA
60 70 80 90 100
LRSGCDLVYT AVPKINAPAT RAASPSMIVI PLADQKLTRG AARKLAGQIP
110 120 130 140 150
TGLDSATIGM GLAIAERSAL KVLVVALVDM DVRISLDAGA LVREILGDIS
160 170 180 190 200
GKNCLVTPHA GEFKRLFGES PPADIEGRAS MVERLAQEHG ITILLKGPTD
210 220 230 240 250
VISDGNRTLL NDRGAPAMTV GGTGDVLSGI AAGILARNRS PLESAAAAAY
260 270 280
INGLAGEAAQ EMHGLHITAM DLCELLPSVM KPFDRLE
Length:287
Mass (Da):30,027
Last modified:March 21, 2012 - v2
Checksum:i6643E7BB0AED62E5
GO

Sequence cautioni

The sequence ABK76899 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000238 Genomic DNA Translation: ABK76899.1 Different initiation.

Genome annotation databases

EnsemblBacteriaiABK76899; ABK76899; CENSYa_0257
KEGGicsy:CENSYa_0257
PATRICifig|414004.10.peg.224

Similar proteinsi

Entry informationi

Entry nameiNNRD_CENSY
AccessioniPrimary (citable) accession number: A0RU82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 21, 2012
Last modified: May 23, 2018
This is version 46 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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