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UniProtKB - A0RU27 (DHQS_CENSY)
Protein
3-dehydroquinate synthase
Gene
aroB'
Organism
Cenarchaeum symbiosum (strain A)
Status
Functioni
Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
UniRule annotationCatalytic activityi
- 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD+ = 3-dehydroquinate + H+ + NADH + NH4+UniRule annotationEC:1.4.1.24UniRule annotation
GO - Molecular functioni
- 3-dehydroquinate synthase activity Source: InterPro
- dehydroquinate synthase activity Source: UniProtKB-EC
- NAD binding Source: UniProtKB-UniRule
GO - Biological processi
- aromatic amino acid family biosynthetic process Source: UniProtKB-UniRule
- cellular amino acid biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | Recommended name: 3-dehydroquinate synthaseUniRule annotation (EC:1.4.1.24UniRule annotation)Short name: DHQ synthaseUniRule annotation Alternative name(s): 3-dehydroquinate synthase IIUniRule annotation |
Gene namesi | Name:aroB'UniRule annotation Ordered Locus Names:CENSYa_0201 |
Organismi | Cenarchaeum symbiosum (strain A) |
Taxonomic identifieri | 414004 [NCBI] |
Taxonomic lineagei | Archaea › Thaumarchaeota › Cenarchaeales › Cenarchaeaceae › Cenarchaeum › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000372043 | 1 – 338 | 3-dehydroquinate synthaseAdd BLAST | 338 |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the archaeal-type DHQ synthase family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_056379_0_0_2 |
OMAi | GDRVCID |
Family and domain databases
HAMAPi | MF_01244, Arch_DHQ_synthase, 1 hit |
InterProi | View protein in InterPro IPR002812, DHQ_synth |
PANTHERi | PTHR33563, PTHR33563, 1 hit |
Pfami | View protein in Pfam PF01959, DHQS, 1 hit |
i Sequence
Sequence statusi: Complete.
A0RU27-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRAQLQRFL SGISAEGIRT VYLDPKDAAK AKLDAMHSSP SSRYVVLEGR
60 70 80 90 100
AAKPRGKKVG RRFKILSNKD IDGVLQEAQK GLDFVITEVQ DWKIIPLENM
110 120 130 140 150
IAKLHKIHTR LYAVARSPAE VRKMFSILDV GVDGVIFTAS TVGDVREALV
160 170 180 190 200
HLGTKSFRLQ PARITEIREV GDGERVCVDT ASMLERGEGM LVGSRSNFMF
210 220 230 240 250
LVHNESVGSS FTSPRPFRVN AGAVHSYTLG TDGNTLYLSE VETGTEVLVL
260 270 280 290 300
DSHGRARRAA VGRSKIERRP MLMIKAEADG EIGGIIAQDA ETIRFVRPGG
310 320 330
GLVSVTHLKK GDKVLVHSKP AAGRHFGMEV ADEYILEK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DP000238 Genomic DNA Translation: ABK76844.1 |
Genome annotation databases
EnsemblBacteriai | ABK76844; ABK76844; CENSYa_0201 |
KEGGi | csy:CENSYa_0201 |
PATRICi | fig|414004.10.peg.176 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DP000238 Genomic DNA Translation: ABK76844.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 414004.CENSYa_0201 |
Genome annotation databases
EnsemblBacteriai | ABK76844; ABK76844; CENSYa_0201 |
KEGGi | csy:CENSYa_0201 |
PATRICi | fig|414004.10.peg.176 |
Phylogenomic databases
HOGENOMi | CLU_056379_0_0_2 |
OMAi | GDRVCID |
Family and domain databases
HAMAPi | MF_01244, Arch_DHQ_synthase, 1 hit |
InterProi | View protein in InterPro IPR002812, DHQ_synth |
PANTHERi | PTHR33563, PTHR33563, 1 hit |
Pfami | View protein in Pfam PF01959, DHQS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DHQS_CENSY | |
Accessioni | A0RU27Primary (citable) accession number: A0RU27 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | January 9, 2007 | |
Last modified: | February 23, 2022 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families