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UniProtKB - A0RDW1 (IOLA1_BACAH)
Protein
Malonate-semialdehyde dehydrogenase 1
Gene
iolA1
Organism
Bacillus thuringiensis (strain Al Hakam)
Status
Functioni
Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.
UniRule annotationCatalytic activityi
- 2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = H+ + hydrogencarbonate + NADH + propanoyl-CoAUniRule annotationEC:1.2.1.27UniRule annotation
: myo-inositol degradation into acetyl-CoA Pathwayi
This protein is involved in step 7 of the subpathway that synthesizes acetyl-CoA from myo-inositol.UniRule annotation This subpathway is part of the pathway myo-inositol degradation into acetyl-CoA, which is itself part of Polyol metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from myo-inositol, the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 286 | NucleophileUniRule annotation | 1 | |
Binding sitei | 386 | NADUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 178 – 182 | NADUniRule annotation | 5 |
GO - Molecular functioni
- malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity Source: RHEA
- malonate-semialdehyde dehydrogenase (acetylating) activity Source: UniProtKB-UniRule
- methylmalonate-semialdehyde dehydrogenase (acylating) activity Source: UniProtKB-UniRule
GO - Biological processi
- inositol catabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
UniPathwayi | UPA00076;UER00148 |
Names & Taxonomyi
Protein namesi | Recommended name: Malonate-semialdehyde dehydrogenase 1UniRule annotation (EC:1.2.1.-UniRule annotation)Short name: MSA dehydrogenase 1UniRule annotation Alternative name(s): Methylmalonate-semialdehyde dehydrogenase 1UniRule annotation (EC:1.2.1.27UniRule annotation) Short name: MMSA dehydrogenase 1UniRule annotation Short name: MSDH 1UniRule annotation |
Gene namesi | Name:iolA1UniRule annotation Ordered Locus Names:BALH_2098 |
Organismi | Bacillus thuringiensis (strain Al Hakam) |
Taxonomic identifieri | 412694 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000352333 | 1 – 486 | Malonate-semialdehyde dehydrogenase 1Add BLAST | 486 |
Interactioni
Subunit structurei
Homotetramer.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_005391_1_10_9 |
OMAi | HIYGNDG |
Family and domain databases
CDDi | cd07085, ALDH_F6_MMSDH, 1 hit |
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
HAMAPi | MF_01670, IolA, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR010061, MeMal-semiAld_DH IPR023510, MSDH_GmP_bac |
PANTHERi | PTHR43866, PTHR43866, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR01722, MMSDH, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit |
i Sequence
Sequence statusi: Complete.
A0RDW1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MITTEIKRVK NHINGEWVES TGTEVEAVPN PATGKIIAYV PLSPKEDVEK
60 70 80 90 100
AVEAAKAAYE TWSKVPVPNR SRQLYKYLQL LQENKEELAK IITLENGKTL
110 120 130 140 150
TDATGEVQRG IEAVELATST PNLMMGQALP NIASGIDGSI WRYPIGVVAG
160 170 180 190 200
ITPFNFPMMI PLWMFPLAIA CGNTFVLKTS ERTPLLAERL VELFYEAGFP
210 220 230 240 250
KGVLNLVQGG KDVVNSILEN KDIQAVSFVG SEPVARYVYE TGTKHGKRVQ
260 270 280 290 300
ALAGAKNHAI VMPDCNLEKT VQGVIGSAFA SSGERCMACS VVAVVDEIAD
310 320 330 340 350
EFIDVLVAET KKLKVGDGFH EDNYVGPLIR ESHKERVLGY INSGVADGAT
360 370 380 390 400
LLVDGRKIKE EVGEGYFVGA TIFDGVNQEM KIWQDEIFAP VLSIVRVKDL
410 420 430 440 450
EEGIKLTNQS KFANGAVIYT SNGKHAQTFR DNIDAGMIGV NVNVPAPMAF
460 470 480
FAFAGNKASF FGDLGTNGTD GVQFYTRKKV VTERWF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000485 Genomic DNA Translation: ABK85404.1 |
RefSeqi | WP_000633357.1, NC_008600.1 |
Genome annotation databases
EnsemblBacteriai | ABK85404; ABK85404; BALH_2098 |
KEGGi | btl:BALH_2098 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000485 Genomic DNA Translation: ABK85404.1 |
RefSeqi | WP_000633357.1, NC_008600.1 |
3D structure databases
AlphaFoldDBi | A0RDW1 |
SMRi | A0RDW1 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | ABK85404; ABK85404; BALH_2098 |
KEGGi | btl:BALH_2098 |
Phylogenomic databases
HOGENOMi | CLU_005391_1_10_9 |
OMAi | HIYGNDG |
Enzyme and pathway databases
UniPathwayi | UPA00076;UER00148 |
Family and domain databases
CDDi | cd07085, ALDH_F6_MMSDH, 1 hit |
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
HAMAPi | MF_01670, IolA, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR010061, MeMal-semiAld_DH IPR023510, MSDH_GmP_bac |
PANTHERi | PTHR43866, PTHR43866, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR01722, MMSDH, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IOLA1_BACAH | |
Accessioni | A0RDW1Primary (citable) accession number: A0RDW1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 14, 2008 |
Last sequence update: | January 9, 2007 | |
Last modified: | May 25, 2022 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families