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Entry version 111 (10 Feb 2021)
Sequence version 1 (09 Jan 2007)
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Protein

Replicative DNA helicase

Gene

MSMEG_6892

Organism
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.UniRule annotationARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotationARBA annotation, HelicaseUniRule annotationImportedARBA annotation, Hydrolase
Biological processDNA replicationUniRule annotationARBA annotation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicative DNA helicaseUniRule annotationARBA annotation (EC:3.6.4.12UniRule annotationARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:MSMEG_6892Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri246196 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000757 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

PrimosomeUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Autocatalytic cleavage, Protein splicingARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
246196.MSMEI_6709

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0R7F4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini197 – 234SF4 helicaseInterPro annotationAdd BLAST38
Domaini374 – 540SF4 helicaseInterPro annotationAdd BLAST167
Domaini655 – 802DOD-type homing endonucleaseInterPro annotationAdd BLAST148
Domaini944 – 966INTEIN_C_TERInterPro annotationAdd BLAST23
Domaini966 – 1024SF4 helicaseInterPro annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. DnaB subfamily.UniRule annotationARBA annotation

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0305, Bacteria
COG1372, Bacteria

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSHEKFV

Database of Orthologous Groups

More...
OrthoDBi
1709134at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.860.10, 1 hit
3.10.28.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036185, DNA_heli_DnaB-like_N_sf
IPR007692, DNA_helicase_DnaB
IPR007694, DNA_helicase_DnaB-like_C
IPR007693, DNA_helicase_DnaB-like_N
IPR016136, DNA_helicase_N/primase_C
IPR003586, Hint_dom_C
IPR003587, Hint_dom_N
IPR036844, Hint_dom_sf
IPR027434, Homing_endonucl
IPR006142, INTEIN
IPR030934, Intein_C
IPR004042, Intein_endonuc
IPR006141, Intein_N
IPR004860, LAGLIDADG_2
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00772, DnaB, 1 hit
PF03796, DnaB_C, 2 hits
PF14528, LAGLIDADG_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00379, INTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00305, HintC, 1 hit
SM00306, HintN, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48024, SSF48024, 1 hit
SSF51294, SSF51294, 2 hits
SSF52540, SSF52540, 2 hits
SSF55608, SSF55608, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00665, DnaB, 1 hit
TIGR01443, intein_Cterm, 1 hit
TIGR01445, intein_Nterm, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50818, INTEIN_C_TER, 1 hit
PS50819, INTEIN_ENDONUCLEASE, 1 hit
PS50817, INTEIN_N_TER, 1 hit
PS51199, SF4_HELICASE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0R7F4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDLGHPDGP ADIDGPPPSG DFGRQPPQDM AAEQAVLGGM LLSKDAIADV
60 70 80 90 100
LERLRPGDFY RPAHQSVYDA ILDLYGRGEP ADAVTVAAEL DRRGLLRRIG
110 120 130 140 150
GAPYLHTLIS TVPTAANAGF YAGIVAEKAL LRRLVEAGTR VVQYGYAGAD
160 170 180 190 200
GADVADIVDR AQAEIYDVTE RRASEDFVPL EDLLQPTMDE IDAIASQGGI
210 220 230 240 250
ARGVPTGFTE LDEVTNGLHA GQMIIIAARP GVGKALALDT PLPTPSGWTT
260 270 280 290 300
MGDVAVGDHL LGPDGEPTRV VADTDVMLGR PCYVVEFSDG TAIVADAQHQ
310 320 330 340 350
WPTEHGVRIT ANLRAGMHTV VSASGGRGGT ALLAPAVQIT AVRRRPSVPV
360 370 380 390 400
RCVEVDNPEH LYLAGPGMVP THNSTLGLDF MRSCSIKHRM ASVIFSLEMS
410 420 430 440 450
KSEIVMRLLS AEAKIKLGDM RSGRMTDDDW TRLARRMSEI SEAPLYIDDS
460 470 480 490 500
PNLTMMEIRA KARRLAQKSD LRLIVVDYMQ LMTSGKKYES RQQEVSDFSR
510 520 530 540 550
SLKLMAKELD VPVVAISQLN RGPEQRTDKR PQVSDLRESG CMTANTRILR
560 570 580 590 600
ADTGAEVTFG ELMATGERPL VWSLDEHKRM VARPMTNVFP SGRKEVFTLR
610 620 630 640 650
MASGREVEAT ANHPFLTLDG WVPLGELKPG DRLATPRLVP EPVNTQRMHD
660 670 680 690 700
SEVVMLAHMI GDGSCVKRQP IRYASIDEGN LLAVETAAEH FGVTPIRDEY
710 720 730 740 750
AAAQVTTLRL PAPYRLTRGK RNPIAEWLDK LGLFGKRSYE KFVPAQVFAL
760 770 780 790 800
PNDQVALFLR HLWATDGSVR WDAKVGQGRV YYATTSRQLA DDVVQLLLRV
810 820 830 840 850
GVYARIKRAK KAGYRDCWHV LIYGRENQKR FVAHVGVHGA RGAAARDLLA
860 870 880 890 900
ELESVTQDTN LDTVPKEVWS QVKAALIERG MSHRAFAKAM GTQFCGSALW
910 920 930 940 950
KHAPSRSRLH RAASLLEDAA LHDLATNDVF WDEIVEITSI GEHDVYDGTV
960 970 980 990 1000
PGTHNFVAQG ISAHNSLEQD ADMVMLLHRP DAFDRDDPRG GEADIILGKH
1010 1020
RNGPTANITV AHQLHFSRFT NMAR
Length:1,024
Mass (Da):112,288
Last modified:January 9, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1B60225192A7C42
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK75351.1

NCBI Reference Sequences

More...
RefSeqi
YP_891092.1, NC_008596.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABK75351; ABK75351; MSMEG_6892

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
msm:MSMEG_6892

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|246196.19.peg.6713

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK75351.1
RefSeqiYP_891092.1, NC_008596.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6OWNX-ray1.95A/B/C235-373[»]
SMRiA0R7F4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEI_6709

Genome annotation databases

EnsemblBacteriaiABK75351; ABK75351; MSMEG_6892
KEGGimsm:MSMEG_6892
PATRICifig|246196.19.peg.6713

Phylogenomic databases

eggNOGiCOG0305, Bacteria
COG1372, Bacteria
OMAiRSHEKFV
OrthoDBi1709134at2

Family and domain databases

Gene3Di1.10.860.10, 1 hit
3.10.28.10, 1 hit
InterProiView protein in InterPro
IPR036185, DNA_heli_DnaB-like_N_sf
IPR007692, DNA_helicase_DnaB
IPR007694, DNA_helicase_DnaB-like_C
IPR007693, DNA_helicase_DnaB-like_N
IPR016136, DNA_helicase_N/primase_C
IPR003586, Hint_dom_C
IPR003587, Hint_dom_N
IPR036844, Hint_dom_sf
IPR027434, Homing_endonucl
IPR006142, INTEIN
IPR030934, Intein_C
IPR004042, Intein_endonuc
IPR006141, Intein_N
IPR004860, LAGLIDADG_2
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00772, DnaB, 1 hit
PF03796, DnaB_C, 2 hits
PF14528, LAGLIDADG_3, 1 hit
PRINTSiPR00379, INTEIN
SMARTiView protein in SMART
SM00305, HintC, 1 hit
SM00306, HintN, 2 hits
SUPFAMiSSF48024, SSF48024, 1 hit
SSF51294, SSF51294, 2 hits
SSF52540, SSF52540, 2 hits
SSF55608, SSF55608, 1 hit
TIGRFAMsiTIGR00665, DnaB, 1 hit
TIGR01443, intein_Cterm, 1 hit
TIGR01445, intein_Nterm, 1 hit
PROSITEiView protein in PROSITE
PS50818, INTEIN_C_TER, 1 hit
PS50819, INTEIN_ENDONUCLEASE, 1 hit
PS50817, INTEIN_N_TER, 1 hit
PS51199, SF4_HELICASE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0R7F4_MYCS2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0R7F4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: February 10, 2021
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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