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Protein

Acetaldehyde dehydrogenase 2

Gene

mhpF

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei127Acyl-thioester intermediateUniRule annotation1
Binding sitei277NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADUniRule annotation4
Nucleotide bindingi158 – 166NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-5906-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Name:mhpFUniRule annotation
Ordered Locus Names:MSMEG_5939, MSMEI_5779
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876811 – 307Acetaldehyde dehydrogenase 2Add BLAST307

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_5939

Structurei

3D structure databases

ProteinModelPortaliA0R4S7
SMRiA0R4S7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK04073
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

A0R4S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKSSVAIV GSGNISTDLL YKLLRSEWLE PRWMIGIDPE SEGLARARKL
60 70 80 90 100
GLETSAEGVD WLLAQSEKPD LVFEATSAYV HRDAAPRYEE AGIRAIDLTP
110 120 130 140 150
AAVGPGVVPP ANLRDHLDAP NVNMVTCGGQ ATIPIVHAVS RVVDVPYAEI
160 170 180 190 200
VASVSSASAG PGTRANIDEF TKTTSAGVQN IGGAQRGKAI IVLNPAEPPM
210 220 230 240 250
IMRDTIFCAI PEGADHDAIT QSIKDVVAEV QTYVPGYRLL NEPQFDEPSV
260 270 280 290 300
VNGGNHLVTT FVEVEGAGDY LPPYAGNLDI MTAAATKVGE EIAKKSAEAS

LASGAQA
Length:307
Mass (Da):32,324
Last modified:November 3, 2009 - v2
Checksum:iA619D96D276AD6F5
GO

Sequence cautioni

The sequence ABK73662 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK73662.1 Different initiation.
CP001663 Genomic DNA Translation: AFP42212.1
RefSeqiWP_014878495.1, NZ_CP009494.1
YP_890165.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK73662; ABK73662; MSMEG_5939
AFP42212; AFP42212; MSMEI_5779
GeneIDi4531880
KEGGimsb:LJ00_29365
msg:MSMEI_5779
msm:MSMEG_5939
PATRICifig|246196.19.peg.5778

Similar proteinsi

Entry informationi

Entry nameiACDH2_MYCS2
AccessioniPrimary (citable) accession number: A0R4S7
Secondary accession number(s): I7G9C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: June 20, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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