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Entry version 120 (10 Feb 2021)
Sequence version 1 (09 Jan 2007)
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Protein

DNA polymerase I

Gene

polA

Organism
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotationARBA annotation, DNA-directed DNA polymeraseUniRule annotationARBA annotation, Hydrolase, NucleaseARBA annotation, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repairUniRule annotation, DNA replicationUniRule annotationARBA annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MSME246196:G1H7P-3831-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase IUniRule annotationARBA annotation (EC:2.7.7.7UniRule annotationARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:polAUniRule annotation
Ordered Locus Names:MSMEG_3839Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri246196 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000757 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A0QYZ2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
246196.MSMEI_3749

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A0QYZ2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-A family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0258, Bacteria
COG0749, Bacteria

Identification of Orthologs from Complete Genome Data

More...
OMAi
IKAMSYG

Database of Orthologous Groups

More...
OrthoDBi
1220182at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09898, H3TH_53EXO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002562, 3'-5'_exonuclease_dom
IPR020046, 5-3_exonucl_a-hlix_arch_N
IPR002421, 5-3_exonuclease
IPR036279, 5-3_exonuclease_C_sf
IPR019760, DNA-dir_DNA_pol_A_CS
IPR001098, DNA-dir_DNA_pol_A_palm_dom
IPR043502, DNA/RNA_pol_sf
IPR020045, DNA_polI_H3TH
IPR018320, DNA_polymerase_1
IPR002298, DNA_polymerase_A
IPR008918, HhH2
IPR029060, PIN-like_dom_sf
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10133, PTHR10133, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01367, 5_3_exonuc, 1 hit
PF02739, 5_3_exonuc_N, 1 hit
PF00476, DNA_pol_A, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00868, DNAPOLI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00474, 35EXOc, 1 hit
SM00475, 53EXOc, 1 hit
SM00279, HhH2, 1 hit
SM00482, POLAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47807, SSF47807, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit
SSF88723, SSF88723, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00593, pola, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00447, DNA_POLYMERASE_A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0QYZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPAKTATKK TPAKAADDTP TLMLLDGNSL AFRAFYALPA ENFKTQSGLT
60 70 80 90 100
TNAVYGFTAM LINLLRDEQP THIAAAFDVS RQTFRKDKYP EYKEGRSATP
110 120 130 140 150
DEFRGQIDIT KEVLGALGIT VLAEPGFEAD DIIATLATQA EQEGYRVLVV
160 170 180 190 200
TGDRDSLQLV SDQVTVLYPR KGVSELTRFT PDAVVEKYGL TPQQYPDFAA
210 220 230 240 250
LRGDPSDNLP GIPGVGEKTA TKWIVEYGSL QALVDNVDAV KGKVGDALRA
260 270 280 290 300
NLSSVILNRE LTDLIRDVPL PQTPDTLRMQ PWNRDQIHRL FDDLEFRVLR
310 320 330 340 350
DRLFETLVAV EPEVEHGFDV RGRALEPGEL AAWLSEHSLG SRFGVAVVGT
360 370 380 390 400
HKAYDADATA LAIVAADGDG RYIDTSTLTP EDEAALASWL ADPGPPKALH
410 420 430 440 450
EAKLAMHDLA GRGWTLRGVT SDTALAAYLV RPGQRSFTLD DLAVRYLHRE
460 470 480 490 500
LRAETPEQQQ LSLLDDSDGV DEQAVQTVIL RACAVLDLAD ALDQELARID
510 520 530 540 550
SLSLLSRMEL PVQRTLAEME HAGIAVDLGM LEQLQSEFAD QIRDAAEAAY
560 570 580 590 600
SVIGKQINLG SPKQLQAVLF DELEMPKTKK TKTGYTTDAD ALQSLFEKTG
610 620 630 640 650
HPFLQHLLAH RDATRLKVTV DGLLNSVASD GRIHTTFNQT IAATGRLSST
660 670 680 690 700
EPNLQNIPIR TEAGRRIRDA FVVGEGYAEL MTADYSQIEM RIMAHLSRDA
710 720 730 740 750
GLIEAFNTGE DLHSFVASRA FSVPIDEVTP ELRRRVKAMS YGLAYGLSAY
760 770 780 790 800
GLAQQLKIST EEAKVQMEQY FDRFGGVRDY LRDVVDQARK DGYTSTVLGR
810 820 830 840 850
RRYLPELDSS NRQVREAAER AALNAPIQGS AADIIKVAMI NVDQAIKDAG
860 870 880 890 900
LRSRILLQVH DELLFEVSEG EQGELEQLVR EHMGNAYPLD VPLEVSVGYG

RSWDAAAH
Length:908
Mass (Da):99,898
Last modified:January 9, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06FD8267A830B194
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK71724.1

NCBI Reference Sequences

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RefSeqi
WP_011729359.1, NZ_SIJM01000005.1
YP_888130.1, NC_008596.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABK71724; ABK71724; MSMEG_3839
AFP40207; AFP40207; MSMEI_3749

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
msm:MSMEG_3839

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|246196.19.peg.3777

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK71724.1
RefSeqiWP_011729359.1, NZ_SIJM01000005.1
YP_888130.1, NC_008596.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6VDCX-ray2.40A304-908[»]
6VDDX-ray1.90A/D304-908[»]
6VDEX-ray2.71A/B1-908[»]
SMRiA0QYZ2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEI_3749

Proteomic databases

PRIDEiA0QYZ2

Genome annotation databases

EnsemblBacteriaiABK71724; ABK71724; MSMEG_3839
AFP40207; AFP40207; MSMEI_3749
KEGGimsm:MSMEG_3839
PATRICifig|246196.19.peg.3777

Phylogenomic databases

eggNOGiCOG0258, Bacteria
COG0749, Bacteria
OMAiIKAMSYG
OrthoDBi1220182at2

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-3831-MONOMER

Family and domain databases

CDDicd09898, H3TH_53EXO, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR002562, 3'-5'_exonuclease_dom
IPR020046, 5-3_exonucl_a-hlix_arch_N
IPR002421, 5-3_exonuclease
IPR036279, 5-3_exonuclease_C_sf
IPR019760, DNA-dir_DNA_pol_A_CS
IPR001098, DNA-dir_DNA_pol_A_palm_dom
IPR043502, DNA/RNA_pol_sf
IPR020045, DNA_polI_H3TH
IPR018320, DNA_polymerase_1
IPR002298, DNA_polymerase_A
IPR008918, HhH2
IPR029060, PIN-like_dom_sf
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
PANTHERiPTHR10133, PTHR10133, 1 hit
PfamiView protein in Pfam
PF01367, 5_3_exonuc, 1 hit
PF02739, 5_3_exonuc_N, 1 hit
PF00476, DNA_pol_A, 1 hit
PRINTSiPR00868, DNAPOLI
SMARTiView protein in SMART
SM00474, 35EXOc, 1 hit
SM00475, 53EXOc, 1 hit
SM00279, HhH2, 1 hit
SM00482, POLAc, 1 hit
SUPFAMiSSF47807, SSF47807, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit
SSF88723, SSF88723, 1 hit
TIGRFAMsiTIGR00593, pola, 1 hit
PROSITEiView protein in PROSITE
PS00447, DNA_POLYMERASE_A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0QYZ2_MYCS2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0QYZ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: February 10, 2021
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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