UniProtKB - A0QYW4 (A0QYW4_MYCS2)
Protein
UvrABC system protein A
Gene
uvrA
Organism
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Status
Functioni
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 32 – 39 | ATPUniRule annotation | 8 | |
Nucleotide bindingi | 651 – 658 | ATPUniRule annotation | 8 | |
Zinc fingeri | 750 – 776 | C4-typeUniRule annotationAdd BLAST | 27 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-UniRule
- DNA binding Source: UniProtKB-UniRule
- excinuclease ABC activity Source: UniProtKB-UniRule
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- nucleotide-excision repair Source: UniProtKB-UniRule
- SOS response Source: UniProtKB-UniRule
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, Excision nucleaseUniRule annotationARBA annotation |
Biological process | DNA damage, DNA excisionUniRule annotationARBA annotation, DNA repair, SOS responseUniRule annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Metal-binding, Nucleotide-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: UvrABC system protein AUniRule annotationShort name: UvrA proteinUniRule annotation Alternative name(s): Excinuclease ABC subunit AUniRule annotation |
Gene namesi | Name:uvrAUniRule annotationImported Ordered Locus Names:MSMEG_3808Imported |
Organismi | Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)Imported |
Taxonomic identifieri | 246196 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycolicibacterium › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
- excinuclease repair complex Source: InterPro
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotationInteractioni
Subunit structurei
Forms a heterotetramer with UvrB during the search for lesions.
UniRule annotationProtein-protein interaction databases
STRINGi | 246196.MSMEI_3720 |
Family & Domainsi
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 750 – 776 | C4-typeUniRule annotationAdd BLAST | 27 |
Keywords - Domaini
RepeatUniRule annotationARBA annotation, Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | COG0178, Bacteria |
OMAi | RAGEPHC |
OrthoDBi | 152379at2 |
Family and domain databases
HAMAPi | MF_00205, UvrA, 1 hit |
InterProi | View protein in InterPro IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase IPR004602, UvrA IPR041552, UvrA_DNA-bd IPR041102, UvrA_inter |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit PF17755, UvrA_DNA-bind, 1 hit PF17760, UvrA_inter, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
TIGRFAMsi | TIGR00630, uvra, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0QYW4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADRLVVKGA REHNLRGVDL DLPRDALIVF TGLSGSGKSS LAFDTIFAEG
60 70 80 90 100
QRRYVESLSA YARQFLGQMD KPDVDFIEGL SPAVSIDQKS TNRNPRSTVG
110 120 130 140 150
TITEVYDYLR LLYARAGTPH CPVCGERIAR QTPQQIVDQV LAMDEGLRFQ
160 170 180 190 200
VLAPVVRTRK GEFVDLFEKL NSQGYSRVRV DGVVYPLTDP PKLKKQEKHD
210 220 230 240 250
IEVVVDRLTV KASAKQRLTD SIETALNLAD GIVVLEFVDR EDDHPHREQR
260 270 280 290 300
FSEKLACPNG HPLAVDDLEP RSFSFNSPYG ACPECTGLGI RKEVDPDLVV
310 320 330 340 350
PDPELTLAEG AVAPWSVGQS AEYFTRMLAG LGEEMGFDVN TPWKKLPAKA
360 370 380 390 400
RRAILEGCDH QVHVRYKNRY GRTRSYYADF EGVMAFLQRR MEQTDSEQMK
410 420 430 440 450
ERYEGFMRDI PCPECNGTRL KPEILAVTLS AGDFGAKSIA QVAELSIADC
460 470 480 490 500
ADFLNSLTLG PREQAIAGQV LKEIQSRLGF LLDVGLDYLS LSRAAATLSG
510 520 530 540 550
GEAQRIRLAT QIGSGLVGVL YVLDEPSIGL HQRDNRRLID TLVRLRDLGN
560 570 580 590 600
TLIVVEHDLD TIAHADWVVD IGPAAGEHGG QIVHSGTYDD LLRNPESLTG
610 620 630 640 650
AYLSGKESIE VPAIRRPVDK KRQITVVGAR ENNLKEIDVA FPLGVLTSVT
660 670 680 690 700
GVSGSGKSTM VNDILATVLA NKLNGARLVP GRHTRVNGLD QLDKLVRVDQ
710 720 730 740 750
SPIGRTPRSN PATYTGVFDK IRSLFAATTE AKVRGYQPGR FSFNVKGGRC
760 770 780 790 800
EACSGDGTIK IEMNFLPDVY VPCEVCHGAR YNRETLEVHY KGKTISEVLD
810 820 830 840 850
MSIEEATEFF EPISSIHRYL KTLVDVGLGY VRLGQPAPTL SGGEAQRVKL
860 870 880 890 900
AAELQKRSTG RTIYILDEPT TGLHFEDIRK LLKVINGLVD KGNTVIVIEH
910 920 930 940 950
NLDVIKTSDW IIDMGPEGGA GGGTVVAQGT PEDVAANPDS YTGKFLAELL
960
DVPTPKRKRR KVSA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000480 Genomic DNA Translation: ABK73411.1 |
RefSeqi | WP_003895254.1, NZ_SIJM01000005.1 YP_888102.1, NC_008596.1 |
Genome annotation databases
EnsemblBacteriai | ABK73411; ABK73411; MSMEG_3808 |
GeneIDi | 45745291 |
KEGGi | msm:MSMEG_3808 |
PATRICi | fig|246196.19.peg.3747 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000480 Genomic DNA Translation: ABK73411.1 |
RefSeqi | WP_003895254.1, NZ_SIJM01000005.1 YP_888102.1, NC_008596.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 246196.MSMEI_3720 |
Proteomic databases
PRIDEi | A0QYW4 |
Genome annotation databases
EnsemblBacteriai | ABK73411; ABK73411; MSMEG_3808 |
GeneIDi | 45745291 |
KEGGi | msm:MSMEG_3808 |
PATRICi | fig|246196.19.peg.3747 |
Phylogenomic databases
eggNOGi | COG0178, Bacteria |
OMAi | RAGEPHC |
OrthoDBi | 152379at2 |
Family and domain databases
HAMAPi | MF_00205, UvrA, 1 hit |
InterProi | View protein in InterPro IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase IPR004602, UvrA IPR041552, UvrA_DNA-bd IPR041102, UvrA_inter |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit PF17755, UvrA_DNA-bind, 1 hit PF17760, UvrA_inter, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
TIGRFAMsi | TIGR00630, uvra, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0QYW4_MYCS2 | |
Accessioni | A0QYW4Primary (citable) accession number: A0QYW4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 9, 2007 |
Last sequence update: | January 9, 2007 | |
Last modified: | April 7, 2021 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |