Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 109 (07 Apr 2021)
Sequence version 1 (09 Jan 2007)
Previous versions | rss
Add a publicationFeedback
Protein

DNA polymerase III subunit alpha

Gene

MSMEG_3178

Organism
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymeraseARBA annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationARBA annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MSME246196:G1H7P-3180-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase III subunit alphaARBA annotation (EC:2.7.7.7ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:MSMEG_3178Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri246196 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000757 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-61662N

Protein interaction database and analysis system

More...
IntActi
A0QX55, 1 interactor

STRING: functional protein association networks

More...
STRINGi
246196.MSMEI_3096

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0587, Bacteria

Identification of Orthologs from Complete Genome Data

More...
OMAi
LHVHTQY

Database of Orthologous Groups

More...
OrthoDBi
561611at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1600, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR041931, DNA_pol3_alpha_thumb_dom
IPR040982, DNA_pol3_finger
IPR029460, DNAPol_HHH
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR016195, Pol/histidinol_Pase-like
IPR004805, PolC_alpha

The PANTHER Classification System

More...
PANTHERi
PTHR32294, PTHR32294, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07733, DNA_pol3_alpha, 1 hit
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00481, POLIIIAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF89550, SSF89550, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00594, polc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0QX55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTDGRSSG SFVHLHNHTE YSMLDGAAKI TPMLAEAQRL EMPAIGMTDH
60 70 80 90 100
GNMFGASEFY NSATKAGIKP IIGIEAYIAP GSRFDTKRVT WGDPGQKGDD
110 120 130 140 150
VSGSGAYTHM TMVAENATGL RNLFKLSSLA SFEGQLGKWS RMDAEIIAEH
160 170 180 190 200
AEGIIATTGC PSGEVQTRLR LGHEREALEA AAKWREIFGP ENFFLELMDH
210 220 230 240 250
GLDIERRVRE GLLEIGRKLG IPPLATNDCH YVTREAARNH EALLCVQTGK
260 270 280 290 300
TLSDPTRFKF DGDGYFLKSA EEMRALWDSQ VPGACDSTLL IGERVQSYAD
310 320 330 340 350
VWEPRDRMPV FPVPEGHDQA SWLTHEVKAG LERRFRGGPV PEEYTTRAEY
360 370 380 390 400
EIKVICDKGF PSYFLIVADL INYARSVGIR VGPGRGSAAG SLVAYALGIT
410 420 430 440 450
NIDPIPHGLL FERFLNPERP SAPDIDIDFD DRRRGEMLRY AANRWGSERV
460 470 480 490 500
AQVITFGTIK TKAALKDSAR VNFGQPGFAI ADRITKALPP PIMAKDIPLS
510 520 530 540 550
GITDPNHERY KEAAEVRGLI DTDPDVRTIY ETARGLEGLV RNAGVHACAV
560 570 580 590 600
IMSSEPLIDA IPLWKRPQDG AIITGWDYPS CEAIGLLKMD FLGLRNLTII
610 620 630 640 650
GDAIANIKAN RGIDLDLETL PLDDPAAYEL LSRGDTLGVF QLDGGPMRDL
660 670 680 690 700
LRRMQPTGFN DIVAVLALYR PGPMGMNAHN DYADRKNGRQ PIKPIHPELE
710 720 730 740 750
EPLKDILAET YGLIVYQEQI MFIAQKVASY TMGKADALRK AMGKKKLEVL
760 770 780 790 800
EAEYKGFKEG MTANGFSEGA VKALWDTILP FAGYAFNKSH AAGYGLVSYW
810 820 830 840 850
TAYLKANYPA EYMAGLLTSV GDDKDKAAVY LADCRRLGIT VLPPDVNESE
860 870 880 890 900
HNFASVGDDI RFGLGAIRNV GANVVSSLIK TRTEKGKFTD FSDYLNKIDI
910 920 930 940 950
TACNKKVTES LIKAGAFDSL GHPRKGLFLV HTDAVDSVLG TKKAEAMGQF
960 970 980 990 1000
DLFGGGEDTG TDAVFTIKVP DEEWEDKHKL ALEREMLGLY VSGHPLNGVA
1010 1020 1030 1040 1050
HLLANQVDTQ IPAILDGDVA NDAQVLVGGI LASVNRRVNK NGLPWASAQL
1060 1070 1080 1090 1100
EDLTGGIEVL FFPQTYSLFG ADIADDVVVL VKAKVAARDD RIALIAHELI
1110 1120 1130 1140 1150
VPDFSSAQAD RPLSVSLPTR QCTIDKVTAL KQVLANHPGT SQVHLRLISG
1160 1170 1180
ERITTLELDQ SLRVTPSSAL MGDLKALLGP GCLG
Length:1,184
Mass (Da):129,207
Last modified:January 9, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i644ED0238072CA06
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK72022.1

NCBI Reference Sequences

More...
RefSeqi
WP_011728872.1, NZ_SIJM01000015.1
YP_887493.1, NC_008596.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABK72022; ABK72022; MSMEG_3178

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
45744694

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
msm:MSMEG_3178

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|246196.19.peg.3139

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK72022.1
RefSeqiWP_011728872.1, NZ_SIJM01000015.1
YP_887493.1, NC_008596.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-61662N
IntActiA0QX55, 1 interactor
STRINGi246196.MSMEI_3096

Genome annotation databases

EnsemblBacteriaiABK72022; ABK72022; MSMEG_3178
GeneIDi45744694
KEGGimsm:MSMEG_3178
PATRICifig|246196.19.peg.3139

Phylogenomic databases

eggNOGiCOG0587, Bacteria
OMAiLHVHTQY
OrthoDBi561611at2

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-3180-MONOMER

Family and domain databases

Gene3Di1.10.10.1600, 1 hit
InterProiView protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR041931, DNA_pol3_alpha_thumb_dom
IPR040982, DNA_pol3_finger
IPR029460, DNAPol_HHH
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR016195, Pol/histidinol_Pase-like
IPR004805, PolC_alpha
PANTHERiPTHR32294, PTHR32294, 1 hit
PfamiView protein in Pfam
PF07733, DNA_pol3_alpha, 1 hit
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit
SMARTiView protein in SMART
SM00481, POLIIIAc, 1 hit
SUPFAMiSSF89550, SSF89550, 1 hit
TIGRFAMsiTIGR00594, polc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0QX55_MYCS2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0QX55
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: April 7, 2021
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again