UniProtKB - A0QWV6 (UVRC_MYCS2)
Protein
UvrABC system protein C
Gene
uvrC
Organism
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Status
Functioni
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- excinuclease ABC activity Source: UniProtKB-UniRule
GO - Biological processi
- nucleotide-excision repair Source: UniProtKB-UniRule
- SOS response Source: UniProtKB-UniRule
Keywordsi
Molecular function | Excision nuclease |
Biological process | DNA damage, DNA excision, DNA repair, SOS response |
Enzyme and pathway databases
BioCyci | MSME246196:G1H7P-3082-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: UvrABC system protein CUniRule annotationShort name: Protein UvrCUniRule annotation Alternative name(s): Excinuclease ABC subunit CUniRule annotation |
Gene namesi | Name:uvrCUniRule annotation Ordered Locus Names:MSMEG_3078, MSMEI_3000 |
Organismi | Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) |
Taxonomic identifieri | 246196 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycolicibacterium › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
- excinuclease repair complex Source: InterPro
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000077809 | 1 – 706 | UvrABC system protein CAdd BLAST | 706 |
Interactioni
Subunit structurei
Interacts with UvrB in an incision complex.
UniRule annotationProtein-protein interaction databases
STRINGi | 246196.MSMEI_3000 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 95 | GIY-YIGUniRule annotationAdd BLAST | 80 | |
Domaini | 208 – 243 | UVRUniRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the UvrC family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0322, Bacteria |
OMAi | LFPIRQC |
OrthoDBi | 1036075at2 |
Family and domain databases
Gene3Di | 3.30.420.340, 1 hit 3.40.1440.10, 1 hit |
HAMAPi | MF_00203, UvrC, 1 hit |
InterProi | View protein in InterPro IPR000305, GIY-YIG_endonuc IPR035901, GIY-YIG_endonuc_sf IPR010994, RuvA_2-like IPR001943, UVR_dom IPR036876, UVR_dom_sf IPR004791, UvrC IPR001162, UvrC_homol_region IPR038476, UvrC_homol_region_sf |
Pfami | View protein in Pfam PF01541, GIY-YIG, 1 hit PF02151, UVR, 1 hit PF08459, UvrC_HhH_N, 1 hit |
SMARTi | View protein in SMART SM00465, GIYc, 1 hit |
SUPFAMi | SSF46600, SSF46600, 1 hit SSF47781, SSF47781, 1 hit SSF82771, SSF82771, 1 hit |
TIGRFAMsi | TIGR00194, uvrC, 1 hit |
PROSITEi | View protein in PROSITE PS50164, GIY_YIG, 1 hit PS50151, UVR, 1 hit PS50165, UVRC, 1 hit |
i Sequence
Sequence statusi: Complete.
A0QWV6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPDPATYRPA PGSIPVEPGV YRFRDPHGRV IYVGKAKSLR SRLTSYFADI
60 70 80 90 100
TSLAPRTRQM VMTAGSVEWT VVTTEVEALQ LEYNWIKEFD PRFNVRYRDD
110 120 130 140 150
KSYPVLAVTL NEEYPRLMVY RGPRRKGVRY FGPYSHAWAI RETLDLLTRV
160 170 180 190 200
FPARTCSAGV FKRHKQIDRP CLLGYIDKCS APCVGRVSAE QHRQIVLDFC
210 220 230 240 250
DFLGGKTDRL AKDMEQQMTA AAEQLDFERA ARLRDDISAL KRALEKQAVV
260 270 280 290 300
FGDGTDADVV AFADDDLEAA VQVFHVRGGR VRGQRGWIVE KSSEPAATGD
310 320 330 340 350
ADLGQSGQEQ LVEQFLTQFY GEQAELGSAS DTGGDEATNP VPRQVLVPVL
360 370 380 390 400
PPNADELATW LSGLRGSRVS LRVPVRGDKR ALAETVQRNA QEALAQHKLK
410 420 430 440 450
RAGDFNARSE ALQSIQEALG LADAPLRIEC VDISHVQGTD VVASLVVFED
460 470 480 490 500
GLPRKSDYRH YAIREAAGDG RSDDVASIAE VTRRRFLRHT SDSQPDPSAE
510 520 530 540 550
QRPRRFAYPP NLFVVDGGAP QVNAAAAVLE DLGVDDVAVI GLAKRLEEVW
560 570 580 590 600
VPSEPDPVIL PRNSEGLYLL QRVRDEAHRF AISYHRSKRS KRMTASALDS
610 620 630 640 650
VRGLGEHRRK ALVAHFGSVA RLKEATVDEI TAVPGIGVAT ARAVQEALGV
660 670 680 690 700
APQNGTAPDP APGTGDPQTP ADPHSAATAA DIEDDRHATG ATGPQMNGSE
QQVDRV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000480 Genomic DNA Translation: ABK74829.1 CP001663 Genomic DNA Translation: AFP39464.1 |
RefSeqi | WP_011728800.1, NZ_SIJM01000002.1 YP_887394.1, NC_008596.1 |
Genome annotation databases
EnsemblBacteriai | ABK74829; ABK74829; MSMEG_3078 AFP39464; AFP39464; MSMEI_3000 |
KEGGi | msg:MSMEI_3000 msm:MSMEG_3078 |
PATRICi | fig|246196.19.peg.3039 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000480 Genomic DNA Translation: ABK74829.1 CP001663 Genomic DNA Translation: AFP39464.1 |
RefSeqi | WP_011728800.1, NZ_SIJM01000002.1 YP_887394.1, NC_008596.1 |
3D structure databases
SMRi | A0QWV6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 246196.MSMEI_3000 |
Genome annotation databases
EnsemblBacteriai | ABK74829; ABK74829; MSMEG_3078 AFP39464; AFP39464; MSMEI_3000 |
KEGGi | msg:MSMEI_3000 msm:MSMEG_3078 |
PATRICi | fig|246196.19.peg.3039 |
Phylogenomic databases
eggNOGi | COG0322, Bacteria |
OMAi | LFPIRQC |
OrthoDBi | 1036075at2 |
Enzyme and pathway databases
BioCyci | MSME246196:G1H7P-3082-MONOMER |
Family and domain databases
Gene3Di | 3.30.420.340, 1 hit 3.40.1440.10, 1 hit |
HAMAPi | MF_00203, UvrC, 1 hit |
InterProi | View protein in InterPro IPR000305, GIY-YIG_endonuc IPR035901, GIY-YIG_endonuc_sf IPR010994, RuvA_2-like IPR001943, UVR_dom IPR036876, UVR_dom_sf IPR004791, UvrC IPR001162, UvrC_homol_region IPR038476, UvrC_homol_region_sf |
Pfami | View protein in Pfam PF01541, GIY-YIG, 1 hit PF02151, UVR, 1 hit PF08459, UvrC_HhH_N, 1 hit |
SMARTi | View protein in SMART SM00465, GIYc, 1 hit |
SUPFAMi | SSF46600, SSF46600, 1 hit SSF47781, SSF47781, 1 hit SSF82771, SSF82771, 1 hit |
TIGRFAMsi | TIGR00194, uvrC, 1 hit |
PROSITEi | View protein in PROSITE PS50164, GIY_YIG, 1 hit PS50151, UVR, 1 hit PS50165, UVRC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UVRC_MYCS2 | |
Accessioni | A0QWV6Primary (citable) accession number: A0QWV6 Secondary accession number(s): I7GAF4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | January 9, 2007 | |
Last modified: | February 10, 2021 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families