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UniProtKB - A0QV25 (A0QV25_MYCS2)

Entry version 108 (07 Apr 2021)
Sequence version 1 (09 Jan 2007)
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Protein

Chromosome partition protein Smc

Gene

smc

Organism
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for chromosome condensation and partitioning.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi32 – 39ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotation
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromosome partition protein SmcUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:smcUniRule annotationImported
Ordered Locus Names:MSMEG_2423Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri246196 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycolicibacterium ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000757 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		A0QV25

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		246196.MSMEI_2362

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini510 – 623SMC hingeInterPro annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili255 – 289UniRule annotationAdd BLAST35
Coiled coili329 – 374UniRule annotationAdd BLAST46
Coiled coili459 – 486UniRule annotationAdd BLAST28
Coiled coili654 – 681UniRule annotationAdd BLAST28
Coiled coili738 – 765UniRule annotationAdd BLAST28
Coiled coili880 – 921UniRule annotationAdd BLAST42

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.UniRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMC family.UniRule annotation

Keywords - Domaini

Coiled coilUniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1196, Bacteria

Identification of Orthologs from Complete Genome Data

More...OMAi		HNKIAME

Database of Orthologous Groups

More...OrthoDBi		1149850at2

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_01894, Smc_prok, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR003395, RecF/RecN/SMC_N
IPR024704, SMC
IPR010935, SMC_hinge
IPR036277, SMC_hinge_sf
IPR011890, SMC_prok

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06470, SMC_hinge, 1 hit
PF02463, SMC_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005719, SMC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00968, SMC_hinge, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit
SSF75553, SSF75553, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR02168, SMC_prok_B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0QV25-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLKSLTLKG FKSFASPTTL RFEPGITCVV GPNGSGKSNV VDALTWVMGE 
        60         70         80         90        100
QGAKTLRGGK MEDVIFAGTS SRAPLGRAEV TLTIDNSDNA LPIEYSEVSI 
       110        120        130        140        150
TRRMFRDGAG EYEINGASCR LMDVQELLSD SGIGREMHVI VGQGKLSEIL 
       160        170        180        190        200
ESRPEDRRAF IEEAAGVLKH RKRKEKAVRK LDSMAANLAR LTDLTTELRR 
       210        220        230        240        250
QLKPLGRQAE MARRAATIQA DLRDARLRLA ADDLVRRQVE FQNTNQAETA 
       260        270        280        290        300
LRKEHEELTV RLQSATVELQ AHEAAVAELT RRAEAAQQTW FRASALAERV 
       310        320        330        340        350
GATVRIATDR AQMLDSEPEM SSGRDPDALE AEAEEVAELE AQLLDELSEA 
       360        370        380        390        400
RIALETARAE LAEREQIAAD AERAHMAAAR AEADRREGLA RLAGQVDTMR 
       410        420        430        440        450
TRVESIDEGV LRLSVSIEEA AAKAEHAQAE FEDVQSRVGE LDAGEVGLDE 
       460        470        480        490        500
HHDRTVAALR LADERVAELQ AAERAAERQV ASLRARIEAL SVGLDRRDGA 
       510        520        530        540        550
AWLQKNHSGG GLFGSIGDFL RVQPGYEVAV AAVLGAAADA LAAENFGAAA 
       560        570        580        590        600
AAVAALKESD GGRAAIVLGD WNAIGSSPQA ALPPGATWAT DLVSVPDRLR 
       610        620        630        640        650
GAVTAMLTGV AVVPDMAAGL ALVSSRPELR AVTTEGDLVG PGWVSGGSDR 
       660        670        680        690        700
KPSTLEIASE IDKARAELEQ AERQTSELGA ALSGALAEQS ARQDAAEQAL 
       710        720        730        740        750
AALNESDAAI SAIYEQLARL GQEARGAHQE WQRLIKQRDE LEAGRTKTVE 
       760        770        780        790        800
ELRELESRLS NAEQTPMFDI EPVDRQETVA AAEAARAVEV EARLAVRTAE 
       810        820        830        840        850
ERANAVRGRA DSLRRAAAAE REARVRAQRA REAREYAARV AAAVSECGRQ 
       860        870        880        890        900
IAGKLSAVVA AAARSRDELA TERQLRVNAL GEIREEVTAL NNRINTLTDA 
       910        920        930        940        950
LHRDEMAKAQ AQLRIEQLEA QVLEQFGMSA GDLVAEYGPQ VALPPSELEM 
       960        970        980        990       1000
AEYEQAKERG EQVTAPAPMP FDRATQERRA KRAERELAEL GRVNPLALEE 
      1010       1020       1030       1040       1050
FAALEERYNF LSTQLEDVKA ARADLLDVIA DVDNRILQVF TEAYADVERE 
      1060       1070       1080       1090       1100
FEQVFATLFP GGEGRLLLTD PSDMLTTGIE VEARPPGKKI KRLSLLSGGE 
      1110       1120       1130       1140       1150
KSLTAVAMLV AIFRARPSPF YVMDEVEAAL DDVNLRRLIS LFEQLREKSQ 
      1160       1170       1180       1190 
LIVITHQKPT MEIADALYGV TMRGDGITTV ISQRMRGQEL VSNPS
Length:1,195
Mass (Da):129,789
Last modified:January 9, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26CDC4A773EB7563
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK74599.1

NCBI Reference Sequences

More...RefSeqi		WP_011728333.1, NZ_SIJM01000012.1
YP_886763.1, NC_008596.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		ABK74599; ABK74599; MSMEG_2423

Database of genes from NCBI RefSeq genomes

More...GeneIDi		45743976

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		msm:MSMEG_2423

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|246196.19.peg.2388

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK74599.1
RefSeqiWP_011728333.1, NZ_SIJM01000012.1
YP_886763.1, NC_008596.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi246196.MSMEI_2362

Proteomic databases

PRIDEiA0QV25

Genome annotation databases

EnsemblBacteriaiABK74599; ABK74599; MSMEG_2423
GeneIDi45743976
KEGGimsm:MSMEG_2423
PATRICifig|246196.19.peg.2388

Phylogenomic databases

eggNOGiCOG1196, Bacteria
OMAiHNKIAME
OrthoDBi1149850at2

Family and domain databases

HAMAPiMF_01894, Smc_prok, 1 hit
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR003395, RecF/RecN/SMC_N
IPR024704, SMC
IPR010935, SMC_hinge
IPR036277, SMC_hinge_sf
IPR011890, SMC_prok
PfamiView protein in Pfam
PF06470, SMC_hinge, 1 hit
PF02463, SMC_N, 1 hit
PIRSFiPIRSF005719, SMC, 1 hit
SMARTiView protein in SMART
SM00968, SMC_hinge, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF75553, SSF75553, 1 hit
TIGRFAMsiTIGR02168, SMC_prok_B, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0QV25_MYCS2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0QV25
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: April 7, 2021
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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