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Entry version 103 (10 Feb 2021)
Sequence version 1 (09 Jan 2007)
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Protein

Error-prone DNA polymerase

Gene

dnaE2

Organism
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymeraseUniRule annotationARBA annotation, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repairUniRule annotationARBA annotation, DNA replicationUniRule annotationARBA annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MSME246196:G1H7P-1642-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Error-prone DNA polymeraseUniRule annotationARBA annotation (EC:2.7.7.7UniRule annotationARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dnaE2UniRule annotation
Ordered Locus Names:MSMEG_1633Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri246196 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000757 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
246196.MSMEI_1593

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 130POLIIIAcInterPro annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 54DisorderedSequence analysisAdd BLAST54

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-C family. DnaE2 subfamily.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0587, Bacteria

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSWPMGF

Database of Orthologous Groups

More...
OrthoDBi
561611at2

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01902, DNApol_error_prone, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR040982, DNA_pol3_finger
IPR023073, DNA_pol_error_prone
IPR029460, DNAPol_HHH
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR016195, Pol/histidinol_Pase-like
IPR004805, PolC_alpha
IPR010994, RuvA_2-like

The PANTHER Classification System

More...
PANTHERi
PTHR32294, PTHR32294, 1 hit
PTHR32294:SF4, PTHR32294:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07733, DNA_pol3_alpha, 1 hit
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00481, POLIIIAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47781, SSF47781, 1 hit
SSF89550, SSF89550, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00594, polc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0QSX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGWHNGPPSW SEMERVLTSK PRRSGLPLES PGDGGDSPAW SRKRGAYEPP
60 70 80 90 100
DQARMPASAL PYAELHAHSA YSFLDGASTP EELVEEAARL NLRAIALTDH
110 120 130 140 150
DGLYGVVRFA EAARELDVAT VFGAELSLSN VARTEDPDPP GPHLLVLARG
160 170 180 190 200
PEGYRRLSRE IAKAHLAGGE KGRPRYDFDQ LTEAAGGHWH ILTGCRKGHV
210 220 230 240 250
RQALSDGGPD AAAAALADLV DRFGADRVSI ELTHHGHPCD DERNAALAEL
260 270 280 290 300
APRFGLGVVA TTAAHFATPS RGRLAMAMAA IRARNSIDTA AGWLAPLGGV
310 320 330 340 350
HLRSGEEMAR LFDPEFVAAA ADLGEQCAFG LALIAPQLPP FDVPDGHTED
360 370 380 390 400
SWLRHLAMAG AARRYGPPER APKAYAQIEH ELRIIEQLRF PGYFLVVHDI
410 420 430 440 450
TQFCRDNNIL CQGRGSAANS AVCYALGVTN VDPIANDLLF ERFLSPARDG
460 470 480 490 500
PPDIDIDIES DLRENVIQYV YERYGRDYAA QVANVITYRG RSAIRDMARA
510 520 530 540 550
LGFSQGQQDA WSKHLSRWDG RPDSPDVAEI PEQVIELANQ IANLPRHMGI
560 570 580 590 600
HSGGMVICDR PIADVCPVEW ARMENRSVLQ WDKDDCAAIG LVKFDMLGLG
610 620 630 640 650
MLSALHYAID LVAEHKGIEV DLATLDLSEP AVYEMLQRAD SVGVFQVESR
660 670 680 690 700
AQMATLPRLK PREFYDLVVE VALIRPGPIQ GGSVHPYIKR RNGQEPVTYD
710 720 730 740 750
HPSMEPALKK TLGVPLFQEQ LMQLAVDCAG FSAAEADQLR RAMGSKRSTA
760 770 780 790 800
KMRRLRSRFY DGMRERHGIT GVVADRIYEK LEAFANFGFP ESHSLSFASL
810 820 830 840 850
VFYSSWFKLH HPAAFCAALL RAQPMGFYSP QSLVADARRH GVTVHGPDVN
860 870 880 890 900
ASLAHAGLEN RGLDVRLGLG SVRHIGDDLA QRIVDEREAN GQFTSLLDLT
910 920 930 940 950
SRVQLTVPQT EALATAGALG CFGITRREGL WAAGAAATQR PDRLPGVGSS
960 970 980 990 1000
THIPPLPGMS ALELSAADVW ATGISPDSYP TEYLRKHLDS LGVVPTDRLL
1010 1020 1030 1040 1050
DVADGTRILV AGAVTHRQRP ATAQGVTFIN LEDEKGMVNV LCAPGVWSRY
1060 1070 1080 1090
RKVAQTAPAL IVRGIVQNAT GAVTVVADRM DAVNLRVGSR SRDFR
Length:1,095
Mass (Da):119,237
Last modified:January 9, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01C0C09E609AFC2A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK73772.1

NCBI Reference Sequences

More...
RefSeqi
WP_011727789.1, NZ_SIJM01000023.1
YP_886009.1, NC_008596.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABK73772; ABK73772; MSMEG_1633

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
45743236

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
msm:MSMEG_1633

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|246196.19.peg.1617

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK73772.1
RefSeqiWP_011727789.1, NZ_SIJM01000023.1
YP_886009.1, NC_008596.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi246196.MSMEI_1593

Genome annotation databases

EnsemblBacteriaiABK73772; ABK73772; MSMEG_1633
GeneIDi45743236
KEGGimsm:MSMEG_1633
PATRICifig|246196.19.peg.1617

Phylogenomic databases

eggNOGiCOG0587, Bacteria
OMAiNSWPMGF
OrthoDBi561611at2

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-1642-MONOMER

Family and domain databases

HAMAPiMF_01902, DNApol_error_prone, 1 hit
InterProiView protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR040982, DNA_pol3_finger
IPR023073, DNA_pol_error_prone
IPR029460, DNAPol_HHH
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR016195, Pol/histidinol_Pase-like
IPR004805, PolC_alpha
IPR010994, RuvA_2-like
PANTHERiPTHR32294, PTHR32294, 1 hit
PTHR32294:SF4, PTHR32294:SF4, 1 hit
PfamiView protein in Pfam
PF07733, DNA_pol3_alpha, 1 hit
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit
SMARTiView protein in SMART
SM00481, POLIIIAc, 1 hit
SUPFAMiSSF47781, SSF47781, 1 hit
SSF89550, SSF89550, 1 hit
TIGRFAMsiTIGR00594, polc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0QSX1_MYCS2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0QSX1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: February 10, 2021
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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