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Protein

60 kDa chaperonin 2

Gene

groL2

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-1593-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin 2UniRule annotation
Alternative name(s):
GroEL protein 2UniRule annotation
Protein Cpn60 2UniRule annotation
Gene namesi
Name:groL2UniRule annotation
Synonyms:groEL2UniRule annotation, groL1
Ordered Locus Names:MSMEG_1583, MSMEI_1545
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00003320192 – 54060 kDa chaperonin 2Add BLAST539

Proteomic databases

PRIDEiA0QSS4

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_1583

Structurei

3D structure databases

ProteinModelPortaliA0QSS4
SMRiA0QSS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0459 LUCA
HOGENOMiHOG000076290
KOiK04077
OMAiYWIASNA
OrthoDBiPOG091H00E7

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0QSS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQIEFNET ARRAMEAGVD KLADAVKVTL GPRGRHVVLA KSFGGPQVTN
60 70 80 90 100
DGVTIAREID LEDPYENLGA QLVKSVATKT NDVAGDGTTT ATVLAQALVR
110 120 130 140 150
AGLRNVAAGA NPIALGSGIS KAADAVSEAL LASATPVDDK KAIAQVATVS
160 170 180 190 200
SRDEQVGELV GEAMTKVGHD GVVTVEESST LETYLEVTEG VGFDKGFLSA
210 220 230 240 250
YFVTDFDSQE AVLEDALVLL HRDKISSLPD LLPLLEKVAE AGKPLLIVAE
260 270 280 290 300
DVEGEALSTL VVNAIRKTLK AVAVKAPFFG DRRKAFLDDL AIVTGGQVVN
310 320 330 340 350
PDVGLLLREV GLEVLGSARR VVVNKDSTVI VDGGGTAEAI ADRVKQIKSE
360 370 380 390 400
IETTDSDWDR EKLQERLAKL AGGVAVIKVG AATETDLKKR KEAVEDAVAA
410 420 430 440 450
AKAAVEEGIV TGGGAALVQA RSAVEKLRGE LSGDEALGVD VFASALSAPL
460 470 480 490 500
YWIATNAGLD GSVVVNKVSE LPKGQGFNAA TLEFGDLVSA GVVDPAKVTR
510 520 530 540
SAVLNAASVA RMILTTETAV VDKPADEDEH GHGHHHGHAH
Length:540
Mass (Da):56,153
Last modified:January 9, 2007 - v1
Checksum:i1486B7068102D546
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK71399.1
CP001663 Genomic DNA Translation: AFP38018.1
RefSeqiWP_011727753.1, NZ_CP009494.1
YP_885962.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK71399; ABK71399; MSMEG_1583
AFP38018; AFP38018; MSMEI_1545
GeneIDi4533270
KEGGimsb:LJ00_07905
msg:MSMEI_1545
msm:MSMEG_1583
PATRICifig|246196.19.peg.1569

Similar proteinsi

Entry informationi

Entry nameiCH602_MYCS2
AccessioniPrimary (citable) accession number: A0QSS4
Secondary accession number(s): I7FGN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 9, 2007
Last modified: June 20, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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