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UniProtKB - A0QS30 (RECC_MYCS2)

Entry version 105 (23 Feb 2022)
Sequence version 2 (19 Mar 2014)
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Protein

RecBCD enzyme subunit RecC

Gene

recC

Organism
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity (By similarity).

Unlike the case in E.coli, suppresses RecA-dependent homologous recombination, is instead required for single-strand annealing pathway repair of DSB.

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.UniRule annotation EC:3.1.11.5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Exonuclease, Helicase, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RecBCD enzyme subunit RecCUniRule annotation (EC:3.1.11.5UniRule annotation)
Alternative name(s):
Exonuclease V subunit RecCUniRule annotation
Short name:
ExoV subunit RecCUniRule annotation
Helicase/nuclease RecBCD subunit RecCUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:recCUniRule annotation
Ordered Locus Names:MSMEG_1328
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri246196 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycolicibacterium ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006158 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Unlike E.coli, triple recB-recC-recD deletion is no more sensitive to DNA damaging agents (UV light sensitivity, mitomycin C, methyl methanesulphonate or ionizing radiation) than wild-type; has reduced resistance to H2O2 which is exacerbated by further adnA-adnB deletion. Triple mutants have no effect on homologous recombination or on NHEJ of blunt-end, 5'- or 3'-overhang DSBs or on incompatible 3'-chromosomal overhangs. However the triple mutant disrupts all single-strand annealing repair of DSB.3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004259421 – 1085RecBCD enzyme subunit RecCAdd BLAST1085

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		246196.MSMEI_1290

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0QS30

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RecC family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1330, Bacteria

Database of Orthologous Groups

More...OrthoDBi		1320159at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.160, 1 hit
3.40.50.300, 2 hits

HAMAP database of protein families

More...HAMAPi		MF_01486, RecC, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013986, DExx_box_DNA_helicase_dom_sf
IPR027417, P-loop_NTPase
IPR006697, RecC
IPR041500, RecC_C
IPR011335, Restrct_endonuc-II-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17946, RecC_C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000980, RecC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits
SSF52980, SSF52980, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01450, recC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0QS30-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALHLHRAER TDLLADGLAA LLSDPLPDPF ATELVLVPAK GVERWLSQRL 
        60         70         80         90        100
SNRLGVCAAV EFRNPRSLIA ELTGTADDDP WSPDAMVWPL LGVIDESLDE 
       110        120        130        140        150
PWCATLATHL GHFEMGEEYE LRQGRRYAVA RRLAGLFASY ARQRPQLLVD 
       160        170        180        190        200
WDGLPDDLAW QKALWQALCE RIDADPPHIR HAKTLVQLHE SPTDLPQRLS 
       210        220        230        240        250
LFGHTRLPAT EVELLTALAT HHDLHLWLPH PSDTLWQALS TRKGPLPRRE 
       260        270        280        290        300
DTSHRDVGHP LLATLGRDLR EMQRLLPEPD TDEFRGRSEY PDTLLGWLQS 
       310        320        330        340        350
DIAADAVRPQ GRHHRREDRS IQVHSCHGPS RQIDVLREVL LGLLADDPTL 
       360        370        380        390        400
EPRDILVMCP DIETYAPLIT AGFGLGDVVP RTRGAHINLS AHPAHKLRVR 
       410        420        430        440        450
LADRALVQTN PLLAVAAQLL ALAGGRATAS EVLNLAESAP VRARFGFTDD 
       460        470        480        490        500
DLDAITAWTR EANIRWGFDQ EHRRPYGVEF LHNTWRFGID RVLAGVAMSD 
       510        520        530        540        550
DSHAWLGTTL PLDDVSSNRV ELAGRFADFV EKLRRTVDQL SGTRPLHEWL 
       560        570        580        590        600
DALTAGIDAL ALADEDWPAA QMQREFAEIT ARAGDTATSL RLADVRALLD 
       610        620        630        640        650
RHLAGRPTRA NFRTGTLTVC TMVPMRSVPH RVVCLVGLDD GVFPRLGAVD 
       660        670        680        690        700
GDDALARDPM TGERDIRSED RQLLLDAILA ATQTLVITYT GANEYSGQAR 
       710        720        730        740        750
PPAVPLAELI DTLKITTEDS ALDVLTRHPL QPFDKRNVIP GALVPDEPFT 
       760        770        780        790        800
FDQTALVAAR ASSGERAMRP AFFSDPLPPP LPDDVALEDL LNFFKDPVKG 
       810        820        830        840        850
FFRALDYTLP WDVEGVSDVM PVDIDALEEW TVGDRMLSDI LRGMTPAAAQ 
       860        870        880        890        900
QAEWRRGTLP PGQLGWRRAI ALRDQCALLA AEALGFRDTD GQAYDVDIDL 
       910        920        930        940        950
GGGRRLTGTV SPVFGDRLVS VTYSKLGGKH LLQSWIPLLA LAAGYPDRDW 
       960        970        980        990       1000
LAVCIGRPAR GTTPRVEGLG GPDNPVDLLA DLVAIYDAGR REPLPLPVKT 
      1010       1020       1030       1040       1050
SYAWAEARHC GDDPEQKAGF RWRSGRYPGE DAEPAHVRAW GRDAWLRDLM 
      1060       1070       1080 
QPLRPGEEFE GETHRLGAYS SRLWLPLLRA ERPVR
Length:1,085
Mass (Da):120,353
Last modified:March 19, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4D9A81AA6A277C4
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABK73955 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK73955.1 Different initiation.
CP001663 Genomic DNA Translation: AFP37766.1

NCBI Reference Sequences

More...RefSeqi		WP_014877040.1, NZ_SIJM01000030.1
YP_885718.1, NC_008596.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		ABK73955; ABK73955; MSMEG_1328
AFP37766; AFP37766; MSMEI_1290

Database of genes from NCBI RefSeq genomes

More...GeneIDi		66732788

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		msg:MSMEI_1290
msm:MSMEG_1328

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|246196.19.peg.1315

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK73955.1 Different initiation.
CP001663 Genomic DNA Translation: AFP37766.1
RefSeqiWP_014877040.1, NZ_SIJM01000030.1
YP_885718.1, NC_008596.1

3D structure databases

SMRiA0QS30
ModBaseiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEI_1290

Genome annotation databases

EnsemblBacteriaiABK73955; ABK73955; MSMEG_1328
AFP37766; AFP37766; MSMEI_1290
GeneIDi66732788
KEGGimsg:MSMEI_1290
msm:MSMEG_1328
PATRICifig|246196.19.peg.1315

Phylogenomic databases

eggNOGiCOG1330, Bacteria
OrthoDBi1320159at2

Family and domain databases

Gene3Di1.10.10.160, 1 hit
3.40.50.300, 2 hits
HAMAPiMF_01486, RecC, 1 hit
InterProiView protein in InterPro
IPR013986, DExx_box_DNA_helicase_dom_sf
IPR027417, P-loop_NTPase
IPR006697, RecC
IPR041500, RecC_C
IPR011335, Restrct_endonuc-II-like
PfamiView protein in Pfam
PF17946, RecC_C, 1 hit
PIRSFiPIRSF000980, RecC, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
SSF52980, SSF52980, 1 hit
TIGRFAMsiTIGR01450, recC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRECC_MYCS2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0QS30
Secondary accession number(s): I7G3M1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: March 19, 2014
Last modified: February 23, 2022
This is version 105 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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