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Protein

Pyrroline-5-carboxylate reductase

Gene

proC

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.UniRule annotation

Catalytic activityi

L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pyrroline-5-carboxylate reductase (proC), Pyrroline-5-carboxylate reductase (proC)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Proline biosynthesisUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00098; UER00361

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroline-5-carboxylate reductaseUniRule annotation (EC:1.5.1.2UniRule annotation)
Short name:
p5C reductaseUniRule annotation
Short name:
p5CRUniRule annotation
Alternative name(s):
PCA reductaseUniRule annotation
Gene namesi
Name:proCUniRule annotationImported
Ordered Locus Names:MSMEG_0943Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
Proteomesi
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_0943

Family & Domainsi

Sequence similaritiesi

Belongs to the pyrroline-5-carboxylate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105II7 Bacteria
COG0345 LUCA
HOGENOMiHOG000230247
KOiK00286
OMAiRVMTNTP
OrthoDBiPOG091H02KJ

Family and domain databases

HAMAPiMF_01925 P5C_reductase, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR028939 P5C_Rdtase_cat_N
IPR029036 P5CR_dimer
IPR000304 Pyrroline-COOH_reductase
PfamiView protein in Pfam
PF03807 F420_oxidored, 1 hit
PF14748 P5CR_dimer, 1 hit
PIRSFiPIRSF000193 Pyrrol-5-carb_rd, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00112 proC, 1 hit
PROSITEiView protein in PROSITE
PS00521 P5CR, 1 hit

Sequencei

Sequence statusi: Complete.

A0QR08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRIAIIGGG SMGEALLSGL LRAGRQVKDM VVAEKFPERA KYLADKYSVR
60 70 80 90 100
VTSVADAAEN AHYVVVAVKP ADVEKVIGEI AEAAANAETD TAEQVFVTIA
110 120 130 140 150
AGVGTAYYEA KLPAGSPVIR VMPNAPVIVG GGVSALAPGR FATPEQLKEV
160 170 180 190 200
STLFDAVGGV ITVSESQLDA VTALSGSGPA YFFLMAEAMV DAGVAVGLSR
210 220 230 240 250
AVATDLVAQT MAGSAAMLLD RLDQVNAAGG AALDTTPAQL RATVTSPAGT
260 270 280
TAAGLRELER GGLRAAVANA VEAAKTRSEQ LGITSE
Length:286
Mass (Da):28,989
Last modified:January 9, 2007 - v1
Checksum:i8D33671128B4AE75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK74403.1
RefSeqiWP_011727304.1, NZ_CP009494.1
YP_885346.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK74403; ABK74403; MSMEG_0943
AFP37400; AFP37400; MSMEI_0920
GeneIDi4531470
KEGGimsb:LJ00_04680
msm:MSMEG_0943
PATRICifig|246196.19.peg.933

Similar proteinsi

Entry informationi

Entry nameiA0QR08_MYCS2
AccessioniPrimary (citable) accession number: A0QR08
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: June 20, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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