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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Mycobacterium avium (strain 104)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno), Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43SubstrateUniRule annotation1
Binding sitei125SubstrateUniRule annotation1
Binding sitei165SubstrateUniRule annotation1
Binding sitei215ATPUniRule annotation1
Binding sitei303ATP; via carbonyl oxygenUniRule annotation1
Binding sitei334ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi363 – 366ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:MAV_3340
OrganismiMycobacterium avium (strain 104)
Taxonomic identifieri243243 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000001574 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000096291 – 415Phosphoglycerate kinaseAdd BLAST415

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0QHY4
SMRiA0QHY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingUniRule annotation3
Regioni66 – 69Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 2 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0QHY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVHNLKDLL AEGVSGRGVL VRSDLNVPLD SDGEQGRITD PGRITASVPT
60 70 80 90 100
LSALVEAGAK VVVAAHLGRP KNGPDPALSL APVAAALGEQ LGRHVQLASD
110 120 130 140 150
VVGTDALARA EGLTDGDVLL LENIRFDARE TSKDDAERLA LARQLAELVG
160 170 180 190 200
PTGAFVSDGF GVVHRKQASV YDVATLLPHY AGTLVAEEIA VLEQLTGSTK
210 220 230 240 250
RPYAVVLGGS KVSDKLGVIE SLATKADSIV IGGGMCFTFL AAQGFSVGKS
260 270 280 290 300
LLETEMVDTC RRLLDTYVDV LRLPVDIVAA DRFAADAAPQ TVPADAIPDD
310 320 330 340 350
LMGLDIGPGS VKRFTALLSN AETIFWNGPM GVFEFPAFAA GTKGLAEAIA
360 370 380 390 400
AATGKGAFSV VGGGDSAAAV RALGIPESGF SHISTGGGAS LEYLEGKALP
410
GIEVLGRPQP TGGAA
Length:415
Mass (Da):42,437
Last modified:January 9, 2007 - v1
Checksum:iA66A383F0A73530B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000479 Genomic DNA Translation: ABK68540.1
RefSeqiWP_003877645.1, NC_008595.1

Genome annotation databases

EnsemblBacteriaiABK68540; ABK68540; MAV_3340
GeneIDi2718074
KEGGimav:MAV_3340

Similar proteinsi

Entry informationi

Entry nameiPGK_MYCA1
AccessioniPrimary (citable) accession number: A0QHY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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