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UniProtKB - A0Q8K7 (A0Q8K7_FRATN)

Entry version 99 (25 May 2022)
Sequence version 1 (09 Jan 2007)
Previous versions | rss
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Protein

Histidine kinase

Gene

kdpD

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.ARBA annotation EC:2.7.13.3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImportedARBA annotation, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		FTUL401614:G1G75-1776-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histidine kinaseARBA annotation (EC:2.7.13.3ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kdpDImported
Ordered Locus Names:FTN_1715Imported
ORF Names:AW25_273Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFrancisella tularensis subsp. novicida (strain U112)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri401614 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000762 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000031872 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei405 – 435HelicalSequence analysisAdd BLAST31
Transmembranei442 – 461HelicalSequence analysisAdd BLAST20
Transmembranei467 – 495HelicalSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini671 – 890Histidine kinaseInterPro annotationAdd BLAST220

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		LWATAFQ

Database of Orthologous Groups

More...OrthoDBi		1293707at2

Family and domain databases

Conserved Domains Database

More...CDDi		cd00082, HisKA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.620, 1 hit
3.30.450.40, 1 hit
3.30.565.10, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029016, GAF-like_dom_sf
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR003661, HisK_dim/P
IPR036097, HisK_dim/P_sf
IPR038318, KdpD_sf
IPR025201, KdpD_TM
IPR027417, P-loop_NTPase
IPR004358, Sig_transdc_His_kin-like_C
IPR003852, Sig_transdc_His_kinase_KdpD_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13493, DUF4118, 1 hit
PF02518, HATPase_c, 1 hit
PF00512, HisKA, 1 hit
PF02702, KdpD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00344, BCTRLSENSOR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00387, HATPase_c, 1 hit
SM00388, HisKA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47384, SSF47384, 1 hit
SSF52540, SSF52540, 1 hit
SSF55874, SSF55874, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50109, HIS_KIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0Q8K7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNQQKVDAL LNLANKSQES KKGKLKIFLG YAPGVGKSYA MLNNARALQK 
        60         70         80         90        100
DNKDVVVGLL VSHGRADTQA LLEGLEIMPL KKVNYRGRVF EELDIDAIKA 
       110        120        130        140        150
RKPDVVIVDE LPHSNLPTSR NKKRYIDIEE LLDEGISVYT AINIQHIASL 
       160        170        180        190        200
SYEVTQLTQA NVNEIVPNDF IQSADELVVV DVSPEELIKR LKQGKVYKSD 
       210        220        230        240        250
AIDRALERYF QYTNLTILRD YTFRMAANHV GQDIQQYRKL YQHGSAIPTS 
       260        270        280        290        300
PYVLVCCGYD EATPSLLRKG KLLATTLNAR LIAVFVQKPN KVATKLNFGV 
       310        320        330        340        350
IRRYKMLASS LGYNIDHILG DRLSDSILEY AKSIGATDLV IGKSIRPKWK 
       360        370        380        390        400
DKLFGSVVYD IIRNNNNGMQ VHIVSINKKE HKLQEQPRHS KIKTKGLIID 
       410        420        430        440        450
VIKSALIAAV SGVFIFFSLS IAGLVSQTLC FLMVLAACAY RYGLIPSIIS 
       460        470        480        490        500
SLVGLFLYIY LYLEPNFVFH ISSLAGIITF AFFMTIVIFS SHVILRTKRA 
       510        520        530        540        550
FTLLKERENS ISVLYRFTKM FNEKSLDKDL RSVFLHALEE YFKCDFVFLS 
       560        570        580        590        600
VSDGELDSAA FPQHPNFNQK ELAAAKWSFK YKDSCGKGTN TFAGLDWAVE 
       610        620        630        640        650
PLVIENRVLG VIAIYLSSET AVERITTDSV ILSSMLSHIS HILLKRNLEK 
       660        670        680        690        700
EEKKSLLLDE QRRLQKSMLS SVSHDLKTPL ASIMGALSSI KSYKDSFNPE 
       710        720        730        740        750
QQVEMLDLAL TESKRLDSYI DNIIQMLKVD SGKLSLNIQN VNSNLFLTEI 
       760        770        780        790        800
QETCARVYNK QKFRFIMPKE QFEIELDPVL FQQVILNLID NAVKFTCDFE 
       810        820        830        840        850
KEIIISLKRK KAAFCLFEVQ DKGIGLRESD MEKIFTIFHR IEKRDSYTHG 
       860        870        880        890 
NGLGLAICKG IVTAHNGKIR VYSDGEGKGS VFKITLPLKS STN
Length:893
Mass (Da):100,857
Last modified:January 9, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD044F5C61E92DB2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CP000439 Genomic DNA Translation: ABK90572.1
CP009633 Genomic DNA Translation: AJI60858.1

NCBI Reference Sequences

More...RefSeqi		WP_003041398.1, NZ_CP009633.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		ABK90572; ABK90572; FTN_1715

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ftn:FTN_1715
ftx:AW25_273

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000439 Genomic DNA Translation: ABK90572.1
CP009633 Genomic DNA Translation: AJI60858.1
RefSeqiWP_003041398.1, NZ_CP009633.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiABK90572; ABK90572; FTN_1715
KEGGiftn:FTN_1715
ftx:AW25_273

Phylogenomic databases

OMAiLWATAFQ
OrthoDBi1293707at2

Enzyme and pathway databases

BioCyciFTUL401614:G1G75-1776-MONOMER

Family and domain databases

CDDicd00082, HisKA, 1 hit
Gene3Di1.20.120.620, 1 hit
3.30.450.40, 1 hit
3.30.565.10, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR029016, GAF-like_dom_sf
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR003661, HisK_dim/P
IPR036097, HisK_dim/P_sf
IPR038318, KdpD_sf
IPR025201, KdpD_TM
IPR027417, P-loop_NTPase
IPR004358, Sig_transdc_His_kin-like_C
IPR003852, Sig_transdc_His_kinase_KdpD_N
PfamiView protein in Pfam
PF13493, DUF4118, 1 hit
PF02518, HATPase_c, 1 hit
PF00512, HisKA, 1 hit
PF02702, KdpD, 1 hit
PRINTSiPR00344, BCTRLSENSOR
SMARTiView protein in SMART
SM00387, HATPase_c, 1 hit
SM00388, HisKA, 1 hit
SUPFAMiSSF47384, SSF47384, 1 hit
SSF52540, SSF52540, 1 hit
SSF55874, SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50109, HIS_KIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0Q8K7_FRATN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0Q8K7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: May 25, 2022
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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