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UniProtKB - A0Q115 (FMT_CLONN)
Protein
Methionyl-tRNA formyltransferase
Gene
fmt
Organism
Clostridium novyi (strain NT)
Status
Functioni
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
UniRule annotationCatalytic activityi
- (6S)-10-formyltetrahydrofolate + L-methionyl-tRNAfMet = (6S)-5,6,7,8-tetrahydrofolate + H+ + N-formyl-L-methionyl-tRNAfMetUniRule annotationEC:2.1.2.9UniRule annotation
GO - Molecular functioni
- methionyl-tRNA formyltransferase activity Source: UniProtKB-UniRule
Keywordsi
Molecular function | Transferase |
Biological process | Protein biosynthesis |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:fmtUniRule annotation Ordered Locus Names:NT01CX_2244 |
Organismi | Clostridium novyi (strain NT) |
Taxonomic identifieri | 386415 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Eubacteriales › Clostridiaceae › Clostridium › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000020048 | 1 – 309 | Methionyl-tRNA formyltransferaseAdd BLAST | 309 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 109 – 112 | Tetrahydrofolate (THF) bindingUniRule annotation | 4 |
Sequence similaritiesi
Belongs to the Fmt family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0223, Bacteria |
HOGENOMi | CLU_033347_1_1_9 |
OMAi | CCPVVAY |
OrthoDBi | 2009156at2 |
Family and domain databases
CDDi | cd08646, FMT_core_Met-tRNA-FMT_N, 1 hit cd08704, Met_tRNA_FMT_C, 1 hit |
Gene3Di | 3.10.25.10, 1 hit |
HAMAPi | MF_00182, Formyl_trans, 1 hit |
InterProi | View protein in InterPro IPR005794, Fmt IPR005793, Formyl_trans_C IPR037022, Formyl_trans_C_sf IPR002376, Formyl_transf_N IPR036477, Formyl_transf_N_sf IPR011034, Formyl_transferase-like_C_sf IPR001555, GART_AS IPR044135, Met-tRNA-FMT_C IPR041711, Met-tRNA-FMT_N |
Pfami | View protein in Pfam PF02911, Formyl_trans_C, 1 hit PF00551, Formyl_trans_N, 1 hit |
SUPFAMi | SSF50486, SSF50486, 1 hit SSF53328, SSF53328, 1 hit |
TIGRFAMsi | TIGR00460, fmt, 1 hit |
PROSITEi | View protein in PROSITE PS00373, GART, 1 hit |
i Sequence
Sequence statusi: Complete.
A0Q115-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIVFMGTPE FAVPSLKAMV ENFNVEGVFT QPDRPKGRGK KLAMSPVKEV
60 70 80 90 100
ALENNIDVYQ PVSLRKEPEF IEKLKNIQPD FIIVVAYGQI LPKEVLEIPK
110 120 130 140 150
YACINLHASL LPKYRGAAPL NWAIINGEKK SGNTTMLMDV GLDTGDMLMT
160 170 180 190 200
QEVDINDSMT AGELHDILMI QGGDLLVDTI NKMVSGEITP IKQDDSKTCY
210 220 230 240 250
ASMLDKKMAC IDWSKSASEI HNLIRGLNPW PVAYTHYDDK VMKIYKSHVL
260 270 280 290 300
NENSKKEPGT VINVSNKGIK VACGEGILVV EEIQFPGKKP LKVEQYIRGN
SIEIESVLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000382 Genomic DNA Translation: ABK61126.1 |
RefSeqi | WP_011722314.1, NC_008593.1 |
Genome annotation databases
EnsemblBacteriai | ABK61126; ABK61126; NT01CX_2244 |
KEGGi | cno:NT01CX_2244 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000382 Genomic DNA Translation: ABK61126.1 |
RefSeqi | WP_011722314.1, NC_008593.1 |
3D structure databases
AlphaFoldDBi | A0Q115 |
SMRi | A0Q115 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 386415.NT01CX_2244 |
Genome annotation databases
EnsemblBacteriai | ABK61126; ABK61126; NT01CX_2244 |
KEGGi | cno:NT01CX_2244 |
Phylogenomic databases
eggNOGi | COG0223, Bacteria |
HOGENOMi | CLU_033347_1_1_9 |
OMAi | CCPVVAY |
OrthoDBi | 2009156at2 |
Family and domain databases
CDDi | cd08646, FMT_core_Met-tRNA-FMT_N, 1 hit cd08704, Met_tRNA_FMT_C, 1 hit |
Gene3Di | 3.10.25.10, 1 hit |
HAMAPi | MF_00182, Formyl_trans, 1 hit |
InterProi | View protein in InterPro IPR005794, Fmt IPR005793, Formyl_trans_C IPR037022, Formyl_trans_C_sf IPR002376, Formyl_transf_N IPR036477, Formyl_transf_N_sf IPR011034, Formyl_transferase-like_C_sf IPR001555, GART_AS IPR044135, Met-tRNA-FMT_C IPR041711, Met-tRNA-FMT_N |
Pfami | View protein in Pfam PF02911, Formyl_trans_C, 1 hit PF00551, Formyl_trans_N, 1 hit |
SUPFAMi | SSF50486, SSF50486, 1 hit SSF53328, SSF53328, 1 hit |
TIGRFAMsi | TIGR00460, fmt, 1 hit |
PROSITEi | View protein in PROSITE PS00373, GART, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FMT_CLONN | |
Accessioni | A0Q115Primary (citable) accession number: A0Q115 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 9, 2007 | |
Last modified: | May 25, 2022 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families