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Protein

Acetaldehyde dehydrogenase 2

Gene

MUL_4096

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei127Acyl-thioester intermediateUniRule annotation1
Binding sitei281NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADUniRule annotation4
Nucleotide bindingi162 – 170NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Ordered Locus Names:MUL_4096
OrganismiMycobacterium ulcerans (strain Agy99)
Taxonomic identifieri362242 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000765 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876911 – 308Acetaldehyde dehydrogenase 2Add BLAST308

Structurei

3D structure databases

ProteinModelPortaliA0PUX3
SMRiA0PUX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000052149
KOiK04073
OMAiTSAYVHK
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

A0PUX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSKASVAIV GSGNISTDLL YKLLRSDWLE PRWMVGIDPQ SEGLARARKL
60 70 80 90 100
GLETTHEGVD WLVAQSDKPD LVFEATSAYV HKAAAPKYAA AGIRAIDLTP
110 120 130 140 150
AAVGPAVVPP ANLREHLDAP NVNMITCGGQ ATIPIVYAVS RAVADLGGVP
160 170 180 190 200
YAEIVASVAS VSAGPGTRAN IDEFTKTTSK GVETIGGARR GKAIIILNPA
210 220 230 240 250
DPPMIMRDTI FCAIPEDADR DAIAASIHEV VAQVQTYVPG YRLLNEPQFD
260 270 280 290 300
EPSINSGGQA VVTTFVEVEG AGDYLPPYAG NLDIMTAAAT KVGEEIAKET

LAVSGGKR
Length:308
Mass (Da):32,272
Last modified:January 9, 2007 - v1
Checksum:i5A2F57689B27BDD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA Translation: ABL06142.1
RefSeqiWP_011741746.1, NC_008611.1

Genome annotation databases

EnsemblBacteriaiABL06142; ABL06142; MUL_4096
KEGGimul:MUL_4096

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA Translation: ABL06142.1
RefSeqiWP_011741746.1, NC_008611.1

3D structure databases

ProteinModelPortaliA0PUX3
SMRiA0PUX3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL06142; ABL06142; MUL_4096
KEGGimul:MUL_4096

Phylogenomic databases

HOGENOMiHOG000052149
KOiK04073
OMAiTSAYVHK
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACDH2_MYCUA
AccessioniPrimary (citable) accession number: A0PUX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: January 9, 2007
Last modified: October 10, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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