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Protein

Palmitoyltransferase ZDHHC22

Gene

Zdhhc22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (By similarity). Might also mediate palmitoylation of NOV/CNN3 (PubMed:29287726).By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.By similarity

GO - Molecular functioni

GO - Biological processi

  • protein localization to plasma membrane Source: MGI
  • protein palmitoylation Source: MGI

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC22 (EC:2.3.1.225By similarity)
Alternative name(s):
Zinc finger DHHC domain-containing protein 22
Short name:
DHHC-22
Short name:
zDHHC22
Gene namesi
Name:Zdhhc22
Synonyms:Gm262
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2685108 Zdhhc22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002787721 – 263Palmitoyltransferase ZDHHC22Add BLAST263

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiA0PK84
PRIDEiA0PK84

Expressioni

Gene expression databases

BgeeiENSMUSG00000048483
CleanExiMM_ZDHHC22

Interactioni

Subunit structurei

Interacts with NOV/CNN3.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093177

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 131DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00730000111268
HOGENOMiHOG000082400
HOVERGENiHBG094179
InParanoidiA0PK84
KOiK18932
OMAiHSISQFF
OrthoDBiEOG091G10XR
PhylomeDBiA0PK84
TreeFamiTF342115

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
IPR000731 SSD
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit
PS50156 SSD, 1 hit

Sequencei

Sequence statusi: Complete.

A0PK84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALRLLNVV APAYFLCISL VTFVLQLFLF LPSMREDPTA TPLFSPAVLH
60 70 80 90 100
GALFLFLSAN ALGNYVLVIQ NSPDDLGTCQ GTMSQRPQCP PPSTHFCRVC
110 120 130 140 150
SRVTLRHDHH CFFTGNCIGS RNMRNFILFC LYTSLACLYS MVAGVAYISA
160 170 180 190 200
VLSISFAHPL AFLTLLPTSI SQFFSGAVLG SDMFVILMLY LWFAVGLACA
210 220 230 240 250
GFCCHQLLLI LRGQTRYQVR KGMAVRARPW RKNLQEVFGK RWLLGLLVPM
260
FNVGTESSKQ QDK
Length:263
Mass (Da):29,318
Last modified:January 9, 2007 - v1
Checksum:i32DA19CA24F9D60F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128021 mRNA Translation: AAI28022.1
CCDSiCCDS36500.1
RefSeqiNP_001074412.1, NM_001080943.2
XP_006515914.1, XM_006515851.2
XP_006515915.1, XM_006515852.3
UniGeneiMm.185890

Genome annotation databases

EnsembliENSMUST00000095521; ENSMUSP00000093177; ENSMUSG00000048483
ENSMUST00000222543; ENSMUSP00000152660; ENSMUSG00000048483
GeneIDi238331
KEGGimmu:238331
UCSCiuc007oie.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZDH22_MOUSE
AccessioniPrimary (citable) accession number: A0PK84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: January 9, 2007
Last modified: July 18, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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