UniProtKB - A0PK05 (TMM72_HUMAN)
Protein
Transmembrane protein 72
Gene
TMEM72
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 72Alternative name(s): Kidney-specific secretory protein of 37 kDa |
Gene namesi | Name:TMEM72 Synonyms:C10orf127, KSP37 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000187783.11 |
HGNCi | HGNC:31658 TMEM72 |
neXtProti | NX_A0PK05 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 16 – 36 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 41 – 61 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 86 – 105 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 109 – 131 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000187783 |
PharmGKBi | PA164726549 |
Polymorphism and mutation databases
BioMutai | TMEM72 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000319055 | 1 – 275 | Transmembrane protein 72Add BLAST | 275 |
Proteomic databases
jPOSTi | A0PK05 |
PaxDbi | A0PK05 |
PRIDEi | A0PK05 |
ProteomicsDBi | 78 79 [A0PK05-2] |
PTM databases
iPTMneti | A0PK05 |
PhosphoSitePlusi | A0PK05 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187783 Expressed in 133 organ(s), highest expression level in adult mammalian kidney |
Genevisiblei | A0PK05 HS |
Organism-specific databases
HPAi | HPA039894 HPA062907 |
Interactioni
Protein-protein interaction databases
IntActi | A0PK05, 8 interactors |
STRINGi | 9606.ENSP00000374234 |
Structurei
3D structure databases
ProteinModelPortali | A0PK05 |
SMRi | A0PK05 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IGB3 Eukaryota ENOG410XXDG LUCA |
GeneTreei | ENSGT00390000006888 |
HOGENOMi | HOG000139671 |
HOVERGENi | HBG094935 |
InParanoidi | A0PK05 |
OMAi | APPEQYT |
OrthoDBi | 1128211at2759 |
PhylomeDBi | A0PK05 |
TreeFami | TF336492 |
Family and domain databases
InterProi | View protein in InterPro IPR032055 TMEM72 |
PANTHERi | PTHR28474 PTHR28474, 1 hit |
Pfami | View protein in Pfam PF16054 TMEM72, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: A0PK05-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MQLQVFWTGL EYTCRLLGIT TAAVLIGVGT ETFLQGQFKS LAFYLLFTGA
60 70 80 90 100
AVSICEGAYF VAQLLAICFQ CQPGSLADRV REKAHWLGCF QKFLAYLLLS
110 120 130 140 150
VACFLHPVLV WHVTIPGSML IITGLAYFLL SKRKKRKAAP EVLASPEQYT
160 170 180 190 200
DPSSSAVSTT GSGDTEQTYT FHGALKEGPS SLFIHMKSIL KGTKKPSALQ
210 220 230 240 250
PPNTLMELSL EPADSLAKKK QVHFEDNLVR IVPSLAEGLD DGDSEPEETT
260 270
SDTTPIIPPP QAPLFLSSLT ATGLF
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031343 | 1 – 118 | Missing in isoform 2. 1 PublicationAdd BLAST | 118 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL353801 Genomic DNA No translation available. AB235418 mRNA Translation: BAF97794.1 BC127789 mRNA Translation: AAI27790.1 BC127790 mRNA Translation: AAI27791.1 |
CCDSi | CCDS41504.1 [A0PK05-1] CCDS86085.1 [A0PK05-2] |
RefSeqi | NP_001116848.1, NM_001123376.2 [A0PK05-1] NP_001332855.1, NM_001345926.1 [A0PK05-2] XP_011538371.1, XM_011540069.2 [A0PK05-2] XP_011538373.1, XM_011540071.2 [A0PK05-2] |
UniGenei | Hs.292788 |
Genome annotation databases
Ensembli | ENST00000389583; ENSP00000374234; ENSG00000187783 [A0PK05-1] ENST00000544540; ENSP00000439911; ENSG00000187783 [A0PK05-2] |
GeneIDi | 643236 |
KEGGi | hsa:643236 |
UCSCi | uc001jbn.3 human [A0PK05-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL353801 Genomic DNA No translation available. AB235418 mRNA Translation: BAF97794.1 BC127789 mRNA Translation: AAI27790.1 BC127790 mRNA Translation: AAI27791.1 |
CCDSi | CCDS41504.1 [A0PK05-1] CCDS86085.1 [A0PK05-2] |
RefSeqi | NP_001116848.1, NM_001123376.2 [A0PK05-1] NP_001332855.1, NM_001345926.1 [A0PK05-2] XP_011538371.1, XM_011540069.2 [A0PK05-2] XP_011538373.1, XM_011540071.2 [A0PK05-2] |
UniGenei | Hs.292788 |
3D structure databases
ProteinModelPortali | A0PK05 |
SMRi | A0PK05 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | A0PK05, 8 interactors |
STRINGi | 9606.ENSP00000374234 |
PTM databases
iPTMneti | A0PK05 |
PhosphoSitePlusi | A0PK05 |
Polymorphism and mutation databases
BioMutai | TMEM72 |
Proteomic databases
jPOSTi | A0PK05 |
PaxDbi | A0PK05 |
PRIDEi | A0PK05 |
ProteomicsDBi | 78 79 [A0PK05-2] |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000389583; ENSP00000374234; ENSG00000187783 [A0PK05-1] ENST00000544540; ENSP00000439911; ENSG00000187783 [A0PK05-2] |
GeneIDi | 643236 |
KEGGi | hsa:643236 |
UCSCi | uc001jbn.3 human [A0PK05-1] |
Organism-specific databases
CTDi | 643236 |
EuPathDBi | HostDB:ENSG00000187783.11 |
GeneCardsi | TMEM72 |
HGNCi | HGNC:31658 TMEM72 |
HPAi | HPA039894 HPA062907 |
neXtProti | NX_A0PK05 |
OpenTargetsi | ENSG00000187783 |
PharmGKBi | PA164726549 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IGB3 Eukaryota ENOG410XXDG LUCA |
GeneTreei | ENSGT00390000006888 |
HOGENOMi | HOG000139671 |
HOVERGENi | HBG094935 |
InParanoidi | A0PK05 |
OMAi | APPEQYT |
OrthoDBi | 1128211at2759 |
PhylomeDBi | A0PK05 |
TreeFami | TF336492 |
Miscellaneous databases
GenomeRNAii | 643236 |
PROi | PR:A0PK05 |
Gene expression databases
Bgeei | ENSG00000187783 Expressed in 133 organ(s), highest expression level in adult mammalian kidney |
Genevisiblei | A0PK05 HS |
Family and domain databases
InterProi | View protein in InterPro IPR032055 TMEM72 |
PANTHERi | PTHR28474 PTHR28474, 1 hit |
Pfami | View protein in Pfam PF16054 TMEM72, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TMM72_HUMAN | |
Accessioni | A0PK05Primary (citable) accession number: A0PK05 Secondary accession number(s): A1L181, Q5T740 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | January 9, 2007 | |
Last modified: | February 13, 2019 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM