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Entry version 101 (29 Sep 2021)
Sequence version 1 (09 Jan 2007)
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Protein

Transmembrane protein 72

Gene

TMEM72

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
A0PK05

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 72
Alternative name(s):
Kidney-specific secretory protein of 37 kDa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM72
Synonyms:C10orf127, KSP37
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:31658, TMEM72

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A0PK05

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000187783

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei86 – 105HelicalSequence analysisAdd BLAST20
Transmembranei109 – 131HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
643236

Open Targets

More...
OpenTargetsi
ENSG00000187783

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164726549

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A0PK05, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM72

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003190551 – 275Transmembrane protein 72Add BLAST275

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
A0PK05

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0PK05

PeptideAtlas

More...
PeptideAtlasi
A0PK05

PRoteomics IDEntifications database

More...
PRIDEi
A0PK05

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78 [A0PK05-1]
79 [A0PK05-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A0PK05

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A0PK05

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187783, Expressed in adult mammalian kidney and 146 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A0PK05, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000187783, Group enriched (kidney, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
568613, 10 interactors

Protein interaction database and analysis system

More...
IntActi
A0PK05, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000374234

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A0PK05, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0PK05

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni141 – 163DisorderedSequence analysisAdd BLAST23
Regioni236 – 262DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi147 – 163Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RXMX, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006888

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_067357_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A0PK05

Identification of Orthologs from Complete Genome Data

More...
OMAi
RWLGCFQ

Database of Orthologous Groups

More...
OrthoDBi
1128211at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A0PK05

TreeFam database of animal gene trees

More...
TreeFami
TF336492

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032055, TMEM72

The PANTHER Classification System

More...
PANTHERi
PTHR28474, PTHR28474, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16054, TMEM72, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A0PK05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQLQVFWTGL EYTCRLLGIT TAAVLIGVGT ETFLQGQFKS LAFYLLFTGA
60 70 80 90 100
AVSICEGAYF VAQLLAICFQ CQPGSLADRV REKAHWLGCF QKFLAYLLLS
110 120 130 140 150
VACFLHPVLV WHVTIPGSML IITGLAYFLL SKRKKRKAAP EVLASPEQYT
160 170 180 190 200
DPSSSAVSTT GSGDTEQTYT FHGALKEGPS SLFIHMKSIL KGTKKPSALQ
210 220 230 240 250
PPNTLMELSL EPADSLAKKK QVHFEDNLVR IVPSLAEGLD DGDSEPEETT
260 270
SDTTPIIPPP QAPLFLSSLT ATGLF
Length:275
Mass (Da):29,891
Last modified:January 9, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37F5996499CA8F65
GO
Isoform 2 (identifier: A0PK05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Show »
Length:157
Mass (Da):16,870
Checksum:iADD507A7DA873754
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0313431 – 118Missing in isoform 2. 1 PublicationAdd BLAST118

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL353801 Genomic DNA No translation available.
AB235418 mRNA Translation: BAF97794.1
BC127789 mRNA Translation: AAI27790.1
BC127790 mRNA Translation: AAI27791.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41504.1 [A0PK05-1]
CCDS86085.1 [A0PK05-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001116848.1, NM_001123376.2 [A0PK05-1]
NP_001332855.1, NM_001345926.1 [A0PK05-2]
XP_011538371.1, XM_011540069.2 [A0PK05-2]
XP_011538373.1, XM_011540071.2 [A0PK05-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389583; ENSP00000374234; ENSG00000187783 [A0PK05-1]
ENST00000544540; ENSP00000439911; ENSG00000187783 [A0PK05-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
643236

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:643236

UCSC genome browser

More...
UCSCi
uc001jbn.3, human [A0PK05-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353801 Genomic DNA No translation available.
AB235418 mRNA Translation: BAF97794.1
BC127789 mRNA Translation: AAI27790.1
BC127790 mRNA Translation: AAI27791.1
CCDSiCCDS41504.1 [A0PK05-1]
CCDS86085.1 [A0PK05-2]
RefSeqiNP_001116848.1, NM_001123376.2 [A0PK05-1]
NP_001332855.1, NM_001345926.1 [A0PK05-2]
XP_011538371.1, XM_011540069.2 [A0PK05-2]
XP_011538373.1, XM_011540071.2 [A0PK05-2]

3D structure databases

SMRiA0PK05
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi568613, 10 interactors
IntActiA0PK05, 10 interactors
STRINGi9606.ENSP00000374234

PTM databases

iPTMnetiA0PK05
PhosphoSitePlusiA0PK05

Genetic variation databases

BioMutaiTMEM72

Proteomic databases

MassIVEiA0PK05
PaxDbiA0PK05
PeptideAtlasiA0PK05
PRIDEiA0PK05
ProteomicsDBi78 [A0PK05-1]
79 [A0PK05-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50461, 22 antibodies

The DNASU plasmid repository

More...
DNASUi
643236

Genome annotation databases

EnsembliENST00000389583; ENSP00000374234; ENSG00000187783 [A0PK05-1]
ENST00000544540; ENSP00000439911; ENSG00000187783 [A0PK05-2]
GeneIDi643236
KEGGihsa:643236
UCSCiuc001jbn.3, human [A0PK05-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
643236
DisGeNETi643236

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM72
HGNCiHGNC:31658, TMEM72
HPAiENSG00000187783, Group enriched (kidney, retina)
neXtProtiNX_A0PK05
OpenTargetsiENSG00000187783
PharmGKBiPA164726549
VEuPathDBiHostDB:ENSG00000187783

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RXMX, Eukaryota
GeneTreeiENSGT00390000006888
HOGENOMiCLU_067357_0_0_1
InParanoidiA0PK05
OMAiRWLGCFQ
OrthoDBi1128211at2759
PhylomeDBiA0PK05
TreeFamiTF336492

Enzyme and pathway databases

PathwayCommonsiA0PK05

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
643236, 0 hits in 951 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
643236
PharosiA0PK05, Tdark

Protein Ontology

More...
PROi
PR:A0PK05
RNActiA0PK05, protein

Gene expression databases

BgeeiENSG00000187783, Expressed in adult mammalian kidney and 146 other tissues
GenevisibleiA0PK05, HS

Family and domain databases

InterProiView protein in InterPro
IPR032055, TMEM72
PANTHERiPTHR28474, PTHR28474, 1 hit
PfamiView protein in Pfam
PF16054, TMEM72, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMM72_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0PK05
Secondary accession number(s): A1L181, Q5T740
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: September 29, 2021
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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