TMEM72

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 72 Alternative name(s): Kidney-specific secretory protein of 37 kDa
Gene namesⁱ	Name:TMEM72 Synonyms:C10orf127, KSP37
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000187783.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31658 TMEM72
neXtProtⁱ	NX_A0PK05

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	16 – 36	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	41 – 61	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	86 – 105	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	109 – 131	HelicalSequence analysisAdd BLAST	23

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000187783
PharmGKBⁱ	PA164726549

Polymorphism and mutation databases

BioMutaⁱ	TMEM72

BioMutaⁱ

TMEM72

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000319055	1 – 275	Transmembrane protein 72Add BLAST		275

Proteomic databases

PaxDbⁱ	A0PK05
PRIDEⁱ	A0PK05
ProteomicsDBⁱ	78 79 [A0PK05-2]

PTM databases

iPTMnetⁱ	A0PK05
PhosphoSitePlusⁱ	A0PK05

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000187783 Expressed in 133 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_TMEM72
Genevisibleⁱ	A0PK05 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039894 HPA062907

HPAⁱ

HPA039894
HPA062907

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	A0PK05, 8 interactors
STRINGⁱ	9606.ENSP00000374234

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A0PK05
SMRⁱ	A0PK05
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IGB3 Eukaryota ENOG410XXDG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006888
HOGENOMⁱ	HOG000139671
HOVERGENⁱ	HBG094935
InParanoidⁱ	A0PK05
OMAⁱ	APPEQYT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G17PW
PhylomeDBⁱ	A0PK05
TreeFamⁱ	TF336492

Family and domain databases

InterProⁱ	View protein in InterPro IPR032055 TMEM72
PANTHERⁱ	PTHR28474 PTHR28474, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16054 TMEM72, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: A0PK05-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQLQVFWTGL EYTCRLLGIT TAAVLIGVGT ETFLQGQFKS LAFYLLFTGA 
        60         70         80         90        100
AVSICEGAYF VAQLLAICFQ CQPGSLADRV REKAHWLGCF QKFLAYLLLS 
       110        120        130        140        150
VACFLHPVLV WHVTIPGSML IITGLAYFLL SKRKKRKAAP EVLASPEQYT 
       160        170        180        190        200
DPSSSAVSTT GSGDTEQTYT FHGALKEGPS SLFIHMKSIL KGTKKPSALQ 
       210        220        230        240        250
PPNTLMELSL EPADSLAKKK QVHFEDNLVR IVPSLAEGLD DGDSEPEETT 
       260        270 
SDTTPIIPPP QAPLFLSSLT ATGLF

Length:275

Mass (Da):29,891

Last modified:January 9, 2007 - v1

Checksum:ⁱ37F5996499CA8F65

GO

Isoform 2 (identifier: A0PK05-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-118: Missing.

« Hide

        10         20         30         40         50
MLIITGLAYF LLSKRKKRKA APEVLASPEQ YTDPSSSAVS TTGSGDTEQT 
        60         70         80         90        100
YTFHGALKEG PSSLFIHMKS ILKGTKKPSA LQPPNTLMEL SLEPADSLAK 
       110        120        130        140        150
KKQVHFEDNL VRIVPSLAEG LDDGDSEPEE TTSDTTPIIP PPQAPLFLSS 

LTATGLF

Note: No experimental confirmation available.

Show »

Length:157

Mass (Da):16,870

Checksum:ⁱADD507A7DA873754

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_031343	1 – 118	Missing in isoform 2. 1 PublicationAdd BLAST		118

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL353801 Genomic DNA No translation available. AB235418 mRNA Translation: BAF97794.1 BC127789 mRNA Translation: AAI27790.1 BC127790 mRNA Translation: AAI27791.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41504.1 [A0PK05-1] CCDS86085.1 [A0PK05-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001116848.1, NM_001123376.2 [A0PK05-1] NP_001332855.1, NM_001345926.1 [A0PK05-2] XP_011538371.1, XM_011540069.2 [A0PK05-2] XP_011538373.1, XM_011540071.2 [A0PK05-2]
UniGeneⁱ	Hs.292788

Genome annotation databases

Ensemblⁱ	ENST00000389583; ENSP00000374234; ENSG00000187783 [A0PK05-1] ENST00000544540; ENSP00000439911; ENSG00000187783 [A0PK05-2]
GeneIDⁱ	643236
KEGGⁱ	hsa:643236
UCSC genome browser More...UCSCⁱ	uc001jbn.3 human [A0PK05-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0PK05	Uncharacterized protein		PANPA		275	UniRef100_A0PK05

Protein	Similar proteins		Species	Score	Length	Source
A0PK05	Uncharacterized protein		PANPA		275	UniRef90_A0PK05
Uncharacterized protein		COLAP		276
TMEM72 isoform 1		PANTR		275
Transmembrane protein 72		SAIBB		275
Transmembrane protein 72		CALJA		275
+16

Protein	Similar proteins		Species	Score	Length	Source
A0PK05	Transmembrane protein 72		MOUSE		275	UniRef50_A0PK05
Uncharacterized protein		PANPA		275
Uncharacterized protein		COLAP		276
Transmembrane protein 72		CALJA		275
Uncharacterized protein		Cebus capucinus imitator		275
+121

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL353801 Genomic DNA No translation available. AB235418 mRNA Translation: BAF97794.1 BC127789 mRNA Translation: AAI27790.1 BC127790 mRNA Translation: AAI27791.1
CCDSⁱ	CCDS41504.1 [A0PK05-1] CCDS86085.1 [A0PK05-2]
RefSeqⁱ	NP_001116848.1, NM_001123376.2 [A0PK05-1] NP_001332855.1, NM_001345926.1 [A0PK05-2] XP_011538371.1, XM_011540069.2 [A0PK05-2] XP_011538373.1, XM_011540071.2 [A0PK05-2]
UniGeneⁱ	Hs.292788

3D structure databases

ProteinModelPortalⁱ	A0PK05
SMRⁱ	A0PK05
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	A0PK05, 8 interactors
STRINGⁱ	9606.ENSP00000374234

PTM databases

iPTMnetⁱ	A0PK05
PhosphoSitePlusⁱ	A0PK05

Polymorphism and mutation databases

BioMutaⁱ	TMEM72

BioMutaⁱ

TMEM72

Proteomic databases

PaxDbⁱ	A0PK05
PRIDEⁱ	A0PK05
ProteomicsDBⁱ	78 79 [A0PK05-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000389583; ENSP00000374234; ENSG00000187783 [A0PK05-1] ENST00000544540; ENSP00000439911; ENSG00000187783 [A0PK05-2]
GeneIDⁱ	643236
KEGGⁱ	hsa:643236
UCSCⁱ	uc001jbn.3 human [A0PK05-1]

Organism-specific databases

CTDⁱ	643236
EuPathDBⁱ	HostDB:ENSG00000187783.11
GeneCardsⁱ	TMEM72
HGNCⁱ	HGNC:31658 TMEM72
HPAⁱ	HPA039894 HPA062907
neXtProtⁱ	NX_A0PK05
OpenTargetsⁱ	ENSG00000187783
PharmGKBⁱ	PA164726549
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGB3 Eukaryota ENOG410XXDG LUCA
GeneTreeⁱ	ENSGT00390000006888
HOGENOMⁱ	HOG000139671
HOVERGENⁱ	HBG094935
InParanoidⁱ	A0PK05
OMAⁱ	APPEQYT
OrthoDBⁱ	EOG091G17PW
PhylomeDBⁱ	A0PK05
TreeFamⁱ	TF336492

Miscellaneous databases

GenomeRNAiⁱ	643236
Protein Ontology More...PROⁱ	PR:A0PK05

Gene expression databases

Bgeeⁱ	ENSG00000187783 Expressed in 133 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_TMEM72
Genevisibleⁱ	A0PK05 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR032055 TMEM72
PANTHERⁱ	PTHR28474 PTHR28474, 1 hit
Pfamⁱ	View protein in Pfam PF16054 TMEM72, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TMM72_HUMAN
Accessionⁱ	A0PK05Primary (citable) accession number: A0PK05 Secondary accession number(s): A1L181, Q5T740
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	January 9, 2007
	Last modified:	September 12, 2018
	This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0PK05 (TMM72_HUMAN)

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Transmembrane protein 72

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ