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Protein

Transmembrane protein 72

Gene

TMEM72

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 72
Alternative name(s):
Kidney-specific secretory protein of 37 kDa
Gene namesi
Name:TMEM72
Synonyms:C10orf127, KSP37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000187783.11
HGNCiHGNC:31658 TMEM72
neXtProtiNX_A0PK05

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei86 – 105HelicalSequence analysisAdd BLAST20
Transmembranei109 – 131HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187783
PharmGKBiPA164726549

Polymorphism and mutation databases

BioMutaiTMEM72

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003190551 – 275Transmembrane protein 72Add BLAST275

Proteomic databases

PaxDbiA0PK05
PRIDEiA0PK05
ProteomicsDBi78
79 [A0PK05-2]

PTM databases

iPTMnetiA0PK05
PhosphoSitePlusiA0PK05

Expressioni

Gene expression databases

BgeeiENSG00000187783 Expressed in 133 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_TMEM72
GenevisibleiA0PK05 HS

Organism-specific databases

HPAiHPA039894
HPA062907

Interactioni

Protein-protein interaction databases

IntActiA0PK05, 8 interactors
STRINGi9606.ENSP00000374234

Structurei

3D structure databases

ProteinModelPortaliA0PK05
SMRiA0PK05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGB3 Eukaryota
ENOG410XXDG LUCA
GeneTreeiENSGT00390000006888
HOGENOMiHOG000139671
HOVERGENiHBG094935
InParanoidiA0PK05
OMAiAPPEQYT
OrthoDBiEOG091G17PW
PhylomeDBiA0PK05
TreeFamiTF336492

Family and domain databases

InterProiView protein in InterPro
IPR032055 TMEM72
PANTHERiPTHR28474 PTHR28474, 1 hit
PfamiView protein in Pfam
PF16054 TMEM72, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A0PK05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQLQVFWTGL EYTCRLLGIT TAAVLIGVGT ETFLQGQFKS LAFYLLFTGA
60 70 80 90 100
AVSICEGAYF VAQLLAICFQ CQPGSLADRV REKAHWLGCF QKFLAYLLLS
110 120 130 140 150
VACFLHPVLV WHVTIPGSML IITGLAYFLL SKRKKRKAAP EVLASPEQYT
160 170 180 190 200
DPSSSAVSTT GSGDTEQTYT FHGALKEGPS SLFIHMKSIL KGTKKPSALQ
210 220 230 240 250
PPNTLMELSL EPADSLAKKK QVHFEDNLVR IVPSLAEGLD DGDSEPEETT
260 270
SDTTPIIPPP QAPLFLSSLT ATGLF
Length:275
Mass (Da):29,891
Last modified:January 9, 2007 - v1
Checksum:i37F5996499CA8F65
GO
Isoform 2 (identifier: A0PK05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):16,870
Checksum:iADD507A7DA873754
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0313431 – 118Missing in isoform 2. 1 PublicationAdd BLAST118

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353801 Genomic DNA No translation available.
AB235418 mRNA Translation: BAF97794.1
BC127789 mRNA Translation: AAI27790.1
BC127790 mRNA Translation: AAI27791.1
CCDSiCCDS41504.1 [A0PK05-1]
CCDS86085.1 [A0PK05-2]
RefSeqiNP_001116848.1, NM_001123376.2 [A0PK05-1]
NP_001332855.1, NM_001345926.1 [A0PK05-2]
XP_011538371.1, XM_011540069.2 [A0PK05-2]
XP_011538373.1, XM_011540071.2 [A0PK05-2]
UniGeneiHs.292788

Genome annotation databases

EnsembliENST00000389583; ENSP00000374234; ENSG00000187783 [A0PK05-1]
ENST00000544540; ENSP00000439911; ENSG00000187783 [A0PK05-2]
GeneIDi643236
KEGGihsa:643236
UCSCiuc001jbn.3 human [A0PK05-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353801 Genomic DNA No translation available.
AB235418 mRNA Translation: BAF97794.1
BC127789 mRNA Translation: AAI27790.1
BC127790 mRNA Translation: AAI27791.1
CCDSiCCDS41504.1 [A0PK05-1]
CCDS86085.1 [A0PK05-2]
RefSeqiNP_001116848.1, NM_001123376.2 [A0PK05-1]
NP_001332855.1, NM_001345926.1 [A0PK05-2]
XP_011538371.1, XM_011540069.2 [A0PK05-2]
XP_011538373.1, XM_011540071.2 [A0PK05-2]
UniGeneiHs.292788

3D structure databases

ProteinModelPortaliA0PK05
SMRiA0PK05
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA0PK05, 8 interactors
STRINGi9606.ENSP00000374234

PTM databases

iPTMnetiA0PK05
PhosphoSitePlusiA0PK05

Polymorphism and mutation databases

BioMutaiTMEM72

Proteomic databases

PaxDbiA0PK05
PRIDEiA0PK05
ProteomicsDBi78
79 [A0PK05-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389583; ENSP00000374234; ENSG00000187783 [A0PK05-1]
ENST00000544540; ENSP00000439911; ENSG00000187783 [A0PK05-2]
GeneIDi643236
KEGGihsa:643236
UCSCiuc001jbn.3 human [A0PK05-1]

Organism-specific databases

CTDi643236
EuPathDBiHostDB:ENSG00000187783.11
GeneCardsiTMEM72
HGNCiHGNC:31658 TMEM72
HPAiHPA039894
HPA062907
neXtProtiNX_A0PK05
OpenTargetsiENSG00000187783
PharmGKBiPA164726549
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGB3 Eukaryota
ENOG410XXDG LUCA
GeneTreeiENSGT00390000006888
HOGENOMiHOG000139671
HOVERGENiHBG094935
InParanoidiA0PK05
OMAiAPPEQYT
OrthoDBiEOG091G17PW
PhylomeDBiA0PK05
TreeFamiTF336492

Miscellaneous databases

GenomeRNAii643236
PROiPR:A0PK05

Gene expression databases

BgeeiENSG00000187783 Expressed in 133 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_TMEM72
GenevisibleiA0PK05 HS

Family and domain databases

InterProiView protein in InterPro
IPR032055 TMEM72
PANTHERiPTHR28474 PTHR28474, 1 hit
PfamiView protein in Pfam
PF16054 TMEM72, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM72_HUMAN
AccessioniPrimary (citable) accession number: A0PK05
Secondary accession number(s): A1L181, Q5T740
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: September 12, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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