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UniProtKB - A0PK00 (T120B_HUMAN)
Protein
Transmembrane protein 120B
Gene
TMEM120B
Organism
Homo sapiens (Human)
Status
Functioni
Necessary for efficient adipogenesis. Does not show ion channel activity.
By similarityGO - Biological processi
- fat cell differentiation Source: UniProtKB
- protein heterooligomerization Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | A0PK00 |
SignaLinki | A0PK00 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 120BCurated |
Gene namesi | Name:TMEM120BImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:32008, TMEM120B |
MIMi | 616551, gene |
neXtProti | NX_A0PK00 |
VEuPathDBi | HostDB:ENSG00000188735 |
Subcellular locationi
Nucleus
- Nucleus inner membrane By similarity; Multi-pass membrane protein Sequence analysis
Nucleus
- nuclear inner membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 102 – 124 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 132 – 152 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 159 – 179 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 187 – 207 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 270 – 290 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 302 – 322 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 144404 |
OpenTargetsi | ENSG00000188735 |
PharmGKBi | PA162405862 |
Miscellaneous databases
Pharosi | A0PK00, Tdark |
Genetic variation databases
BioMutai | TMEM120B |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309529 | 1 – 339 | Transmembrane protein 120BAdd BLAST | 339 |
Proteomic databases
EPDi | A0PK00 |
jPOSTi | A0PK00 |
MassIVEi | A0PK00 |
MaxQBi | A0PK00 |
PaxDbi | A0PK00 |
PeptideAtlasi | A0PK00 |
PRIDEi | A0PK00 |
ProteomicsDBi | 76 |
PTM databases
iPTMneti | A0PK00 |
PhosphoSitePlusi | A0PK00 |
SwissPalmi | A0PK00 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188735, Expressed in right hemisphere of cerebellum and 192 other tissues |
ExpressionAtlasi | A0PK00, baseline and differential |
Genevisiblei | A0PK00, HS |
Organism-specific databases
HPAi | ENSG00000188735, Low tissue specificity |
Interactioni
Subunit structurei
Heterooligomer with TMEM120A.
By similarityBinary interactionsi
A0PK00
Protein-protein interaction databases
BioGRIDi | 126849, 108 interactors |
IntActi | A0PK00, 69 interactors |
STRINGi | 9606.ENSP00000404991 |
Miscellaneous databases
RNActi | A0PK00, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1 – 77 | Sequence analysisAdd BLAST | 77 |
Sequence similaritiesi
Belongs to the TMEM120 family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4758, Eukaryota |
GeneTreei | ENSGT00390000007848 |
HOGENOMi | CLU_048749_1_1_1 |
InParanoidi | A0PK00 |
OMAi | WFNVYIS |
OrthoDBi | 916768at2759 |
PhylomeDBi | A0PK00 |
TreeFami | TF313552 |
Family and domain databases
InterProi | View protein in InterPro IPR012926, TACAN/TMEM120B |
PANTHERi | PTHR21433, PTHR21433, 1 hit |
Pfami | View protein in Pfam PF07851, TMPIT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A0PK00-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELAALQ TLCSSSISKQ
60 70 80 90 100
KKHLKDLKLT LQRCKRHASR EEAELVQQMA ANIKERQDVF FDMEAYLPKK
110 120 130 140 150
NGLYLNLVLG NVNVTLLSNQ AKFAYKDEYE KFKLYLTIIL LLGAVACRFV
160 170 180 190 200
LHYRVTDEVF NFLLVWYYCT LTIRESILIS NGSRIKGWWV SHHYVSTFLS
210 220 230 240 250
GVMLTWPNGP IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC LYRLRALGER
260 270 280 290 300
NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE
310 320 330
WQVFVLAFTF LILFLGNFLT TLKVVHAKLQ KNRGKTKQP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YG77 | H0YG77_HUMAN | Transmembrane protein 120B | TMEM120B | 247 | Annotation score: | ||
F5H465 | F5H465_HUMAN | Transmembrane protein 120B | TMEM120B | 92 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 92 | D → N in AAI27770 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126568 mRNA Translation: BAG54345.1 BC127768 mRNA Translation: AAI27769.1 BC127769 mRNA Translation: AAI27770.1 |
CCDSi | CCDS41852.1 |
RefSeqi | NP_001074294.2, NM_001080825.2 XP_016874342.1, XM_017018853.1 |
Genome annotation databases
Ensembli | ENST00000342607; ENSP00000345152; ENSG00000188735 ENST00000449592; ENSP00000404991; ENSG00000188735 |
GeneIDi | 144404 |
KEGGi | hsa:144404 |
MANE-Selecti | ENST00000449592.7; ENSP00000404991.2; NM_001080825.2; NP_001074294.2 |
UCSCi | uc001ubc.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126568 mRNA Translation: BAG54345.1 BC127768 mRNA Translation: AAI27769.1 BC127769 mRNA Translation: AAI27770.1 |
CCDSi | CCDS41852.1 |
RefSeqi | NP_001074294.2, NM_001080825.2 XP_016874342.1, XM_017018853.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7F73 | electron microscopy | 4.00 | A/B | 1-339 | [»] | |
SMRi | A0PK00 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 126849, 108 interactors |
IntActi | A0PK00, 69 interactors |
STRINGi | 9606.ENSP00000404991 |
PTM databases
iPTMneti | A0PK00 |
PhosphoSitePlusi | A0PK00 |
SwissPalmi | A0PK00 |
Genetic variation databases
BioMutai | TMEM120B |
Proteomic databases
EPDi | A0PK00 |
jPOSTi | A0PK00 |
MassIVEi | A0PK00 |
MaxQBi | A0PK00 |
PaxDbi | A0PK00 |
PeptideAtlasi | A0PK00 |
PRIDEi | A0PK00 |
ProteomicsDBi | 76 |
Protocols and materials databases
Antibodypediai | 2742, 41 antibodies from 14 providers |
DNASUi | 144404 |
Genome annotation databases
Ensembli | ENST00000342607; ENSP00000345152; ENSG00000188735 ENST00000449592; ENSP00000404991; ENSG00000188735 |
GeneIDi | 144404 |
KEGGi | hsa:144404 |
MANE-Selecti | ENST00000449592.7; ENSP00000404991.2; NM_001080825.2; NP_001074294.2 |
UCSCi | uc001ubc.5, human |
Organism-specific databases
CTDi | 144404 |
DisGeNETi | 144404 |
GeneCardsi | TMEM120B |
HGNCi | HGNC:32008, TMEM120B |
HPAi | ENSG00000188735, Low tissue specificity |
MIMi | 616551, gene |
neXtProti | NX_A0PK00 |
OpenTargetsi | ENSG00000188735 |
PharmGKBi | PA162405862 |
VEuPathDBi | HostDB:ENSG00000188735 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4758, Eukaryota |
GeneTreei | ENSGT00390000007848 |
HOGENOMi | CLU_048749_1_1_1 |
InParanoidi | A0PK00 |
OMAi | WFNVYIS |
OrthoDBi | 916768at2759 |
PhylomeDBi | A0PK00 |
TreeFami | TF313552 |
Enzyme and pathway databases
PathwayCommonsi | A0PK00 |
SignaLinki | A0PK00 |
Miscellaneous databases
BioGRID-ORCSi | 144404, 7 hits in 1050 CRISPR screens |
ChiTaRSi | TMEM120B, human |
GenomeRNAii | 144404 |
Pharosi | A0PK00, Tdark |
PROi | PR:A0PK00 |
RNActi | A0PK00, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188735, Expressed in right hemisphere of cerebellum and 192 other tissues |
ExpressionAtlasi | A0PK00, baseline and differential |
Genevisiblei | A0PK00, HS |
Family and domain databases
InterProi | View protein in InterPro IPR012926, TACAN/TMEM120B |
PANTHERi | PTHR21433, PTHR21433, 1 hit |
Pfami | View protein in Pfam PF07851, TMPIT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | T120B_HUMAN | |
Accessioni | A0PK00Primary (citable) accession number: A0PK00 Secondary accession number(s): A0PK01, B3KX33 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | January 9, 2007 | |
Last modified: | February 23, 2022 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families