UniProtKB - A0PK00 (T120B_HUMAN)

BLAST

>sp|A0PK00|T120B_HUMAN Transmembrane protein 120B OS=Homo sapiens OX=9606 GN=TMEM120B PE=1 SV=1
MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELAALQTLCSSSISKQKKHLKDLKLT
LQRCKRHASREEAELVQQMAANIKERQDVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQ
AKFAYKDEYEKFKLYLTIILLLGAVACRFVLHYRVTDEVFNFLLVWYYCTLTIRESILIS
NGSRIKGWWVSHHYVSTFLSGVMLTWPNGPIYQKFRNQFLAFSIFQSCVQFLQYYYQRGC
LYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECRE
WQVFVLAFTFLILFLGNFLTTLKVVHAKLQKNRGKTKQP

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History
Entry version 90 (12 Sep 2018)
Sequence version 1 (09 Jan 2007)
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Protein

Transmembrane protein 120B

Gene

TMEM120B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Necessary for efficient adipogenesis.By similarity

GO - Biological processⁱ

fat cell differentiation Source: UniProtKB
protein heterooligomerization Source: UniProtKB

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 120B
Gene namesⁱ	Name:TMEM120B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188735.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:32008 TMEM120B
MIMⁱ	616551 gene
neXtProtⁱ	NX_A0PK00

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	102 – 124	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	132 – 152	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	159 – 179	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	187 – 207	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	270 – 290	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	302 – 322	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	144404
Open Targets More...OpenTargetsⁱ	ENSG00000188735
PharmGKBⁱ	PA162405862

Polymorphism and mutation databases

BioMutaⁱ	TMEM120B

BioMutaⁱ

TMEM120B

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000309529	1 – 339	Transmembrane protein 120BAdd BLAST		339

Proteomic databases

EPDⁱ	A0PK00
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A0PK00
PaxDbⁱ	A0PK00
PRIDEⁱ	A0PK00
ProteomicsDBⁱ	76

PTM databases

iPTMnetⁱ	A0PK00
PhosphoSitePlusⁱ	A0PK00
SwissPalmⁱ	A0PK00

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000188735 Expressed in 177 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasⁱ	A0PK00 baseline and differential
Genevisibleⁱ	A0PK00 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014066

HPAⁱ

HPA014066

Interactionⁱ

Subunit structureⁱ

Heterooligomer with TMEM120A.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CCNDBP1	O95273	3	EBI-10171534,EBI-748961

With

Entry

#Exp.

IntAct

Notes

CCNDBP1

O95273

EBI-10171534,EBI-748961

Protein-protein interaction databases

BioGridⁱ	126849, 31 interactors
IntActⁱ	A0PK00, 51 interactors
STRINGⁱ	9606.ENSP00000345152

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A0PK00
SMRⁱ	A0PK00
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	1 – 77	Sequence analysisAdd BLAST		77

Sequence similaritiesⁱ

Belongs to the TMEM120 family.Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4758 Eukaryota ENOG410XT6G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007848
HOGENOMⁱ	HOG000267032
HOVERGENⁱ	HBG108532
InParanoidⁱ	A0PK00
OMAⁱ	QNIFFDM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BVA
PhylomeDBⁱ	A0PK00
TreeFamⁱ	TF313552

Family and domain databases

InterProⁱ	View protein in InterPro IPR012926 TMPIT
PANTHERⁱ	PTHR21433 PTHR21433, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07851 TMPIT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

A0PK00-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELAALQ TLCSSSISKQ 
        60         70         80         90        100
KKHLKDLKLT LQRCKRHASR EEAELVQQMA ANIKERQDVF FDMEAYLPKK 
       110        120        130        140        150
NGLYLNLVLG NVNVTLLSNQ AKFAYKDEYE KFKLYLTIIL LLGAVACRFV 
       160        170        180        190        200
LHYRVTDEVF NFLLVWYYCT LTIRESILIS NGSRIKGWWV SHHYVSTFLS 
       210        220        230        240        250
GVMLTWPNGP IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC LYRLRALGER 
       260        270        280        290        300
NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE 
       310        320        330 
WQVFVLAFTF LILFLGNFLT TLKVVHAKLQ KNRGKTKQP

Length:339

Mass (Da):40,246

Last modified:January 9, 2007 - v1

Checksum:ⁱ15A08B563ED261D3

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YG77	H0YG77_HUMAN	Transmembrane protein 120B Transmembrane protein 120B	TMEM120B	247	Annotation score:
F5H465	F5H465_HUMAN	Transmembrane protein 120B Transmembrane protein 120B	TMEM120B	92	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	92	D → N in AAI27770 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK126568 mRNA Translation: BAG54345.1 BC127768 mRNA Translation: AAI27769.1 BC127769 mRNA Translation: AAI27770.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41852.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001074294.2, NM_001080825.2 XP_016874342.1, XM_017018853.1
UniGeneⁱ	Hs.644504 Hs.744740

Genome annotation databases

Ensemblⁱ	ENST00000342607; ENSP00000345152; ENSG00000188735 ENST00000449592; ENSP00000404991; ENSG00000188735
GeneIDⁱ	144404
KEGGⁱ	hsa:144404
UCSC genome browser More...UCSCⁱ	uc001ubc.5 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0PK00	Transmembrane protein 120B		MOUSE		339	UniRef90_Q3TA38
Transmembrane protein 120B		BOVIN		339
Transmembrane protein 120B		CANLF		340
Transmembrane protein 120B		PIG		339
transmembrane protein 120B		DELLE		339
+94

Protein	Similar proteins		Species	Score	Length	Source
A0PK00	Transmembrane protein 120A		HUMAN		343	UniRef50_Q9BXJ8
Transmembrane protein 120A		MOUSE		343
Transmembrane protein 120A		BOVIN		343
Transmembrane protein 120A		RAT		343
Transmembrane protein 120B		DANRE		337
+416

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK126568 mRNA Translation: BAG54345.1 BC127768 mRNA Translation: AAI27769.1 BC127769 mRNA Translation: AAI27770.1
CCDSⁱ	CCDS41852.1
RefSeqⁱ	NP_001074294.2, NM_001080825.2 XP_016874342.1, XM_017018853.1
UniGeneⁱ	Hs.644504 Hs.744740

3D structure databases

ProteinModelPortalⁱ	A0PK00
SMRⁱ	A0PK00
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126849, 31 interactors
IntActⁱ	A0PK00, 51 interactors
STRINGⁱ	9606.ENSP00000345152

PTM databases

iPTMnetⁱ	A0PK00
PhosphoSitePlusⁱ	A0PK00
SwissPalmⁱ	A0PK00

Polymorphism and mutation databases

BioMutaⁱ	TMEM120B

BioMutaⁱ

TMEM120B

Proteomic databases

EPDⁱ	A0PK00
MaxQBⁱ	A0PK00
PaxDbⁱ	A0PK00
PRIDEⁱ	A0PK00
ProteomicsDBⁱ	76

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000342607; ENSP00000345152; ENSG00000188735 ENST00000449592; ENSP00000404991; ENSG00000188735
GeneIDⁱ	144404
KEGGⁱ	hsa:144404
UCSCⁱ	uc001ubc.5 human

Organism-specific databases

CTDⁱ	144404
DisGeNETⁱ	144404
EuPathDBⁱ	HostDB:ENSG00000188735.12
GeneCardsⁱ	TMEM120B
HGNCⁱ	HGNC:32008 TMEM120B
HPAⁱ	HPA014066
MIMⁱ	616551 gene
neXtProtⁱ	NX_A0PK00
OpenTargetsⁱ	ENSG00000188735
PharmGKBⁱ	PA162405862
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4758 Eukaryota ENOG410XT6G LUCA
GeneTreeⁱ	ENSGT00390000007848
HOGENOMⁱ	HOG000267032
HOVERGENⁱ	HBG108532
InParanoidⁱ	A0PK00
OMAⁱ	QNIFFDM
OrthoDBⁱ	EOG091G0BVA
PhylomeDBⁱ	A0PK00
TreeFamⁱ	TF313552

Miscellaneous databases

ChiTaRSⁱ	TMEM120B human
GenomeRNAiⁱ	144404
Protein Ontology More...PROⁱ	PR:A0PK00
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000188735 Expressed in 177 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasⁱ	A0PK00 baseline and differential
Genevisibleⁱ	A0PK00 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR012926 TMPIT
PANTHERⁱ	PTHR21433 PTHR21433, 1 hit
Pfamⁱ	View protein in Pfam PF07851 TMPIT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	T120B_HUMAN
Accessionⁱ	A0PK00Primary (citable) accession number: A0PK00 Secondary accession number(s): A0PK01, B3KX33
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	January 9, 2007
	Last modified:	September 12, 2018
	This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - A0PK00 (T120B_HUMAN)

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Transmembrane protein 120B

TMEM120B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ