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UniProtKB - A0PK00 (T120B_HUMAN)

Entry version 107 (23 Feb 2022)
Sequence version 1 (09 Jan 2007)
Previous versions | rss
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Protein

Transmembrane protein 120B

Gene

TMEM120B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Necessary for efficient adipogenesis. Does not show ion channel activity.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A0PK00

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		A0PK00

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 120BCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM120BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:32008, TMEM120B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616551, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A0PK00

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000188735

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei102 – 124HelicalSequence analysisAdd BLAST23
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		144404

Open Targets

More...OpenTargetsi		ENSG00000188735

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162405862

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A0PK00, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM120B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003095291 – 339Transmembrane protein 120BAdd BLAST339

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A0PK00

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A0PK00

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A0PK00

MaxQB - The MaxQuant DataBase

More...MaxQBi		A0PK00

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A0PK00

PeptideAtlas

More...PeptideAtlasi		A0PK00

PRoteomics IDEntifications database

More...PRIDEi		A0PK00

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A0PK00

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A0PK00

SwissPalm database of S-palmitoylation events

More...SwissPalmi		A0PK00

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188735, Expressed in right hemisphere of cerebellum and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0PK00, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A0PK00, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188735, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterooligomer with TMEM120A.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

A0PK00
With#Exp.IntAct
ALOX5AP [P20292]3EBI-10171534,EBI-3904621
ANKS6 [Q68DC2]3EBI-10171534,EBI-7054139
APOA5 [Q6Q788]3EBI-10171534,EBI-3936819
AQP6 [Q13520]3EBI-10171534,EBI-13059134
AQP8 [O94778]3EBI-10171534,EBI-19124986
BNIP3L [O60238]3EBI-10171534,EBI-849893
CCNDBP1 [O95273]3EBI-10171534,EBI-748961
CD74 - isoform p35 [P04233-2]3EBI-10171534,EBI-12222807
COMT [P21964]3EBI-10171534,EBI-372265
CPLX4 [Q7Z7G2]3EBI-10171534,EBI-18013275
CREB3L1 [Q96BA8]5EBI-10171534,EBI-6942903
EBP [Q15125]3EBI-10171534,EBI-3915253
ERGIC3 [Q9Y282]3EBI-10171534,EBI-781551
FFAR2 [O15552]3EBI-10171534,EBI-2833872
FKBP7 [Q9Y680]3EBI-10171534,EBI-3918971
GAD2 [Q05329]3EBI-10171534,EBI-9304251
GJB1 [P08034]3EBI-10171534,EBI-17565645
GORAB [Q5T7V8]3EBI-10171534,EBI-3917143
GPR152 [Q8TDT2]3EBI-10171534,EBI-13345167
GPRC5D [Q9NZD1]3EBI-10171534,EBI-13067820
GPX8 [Q8TED1]3EBI-10171534,EBI-11721746
HSD17B11 [Q8NBQ5]3EBI-10171534,EBI-1052304
IFNGR2 [P38484]3EBI-10171534,EBI-3905457
IL7R [P16871]3EBI-10171534,EBI-80490
JAGN1 [Q8N5M9]3EBI-10171534,EBI-10266796
JPH1 [Q9HDC5]3EBI-10171534,EBI-465137
KCNJ6 [P48051]3EBI-10171534,EBI-12017638
LRRTM2 [O43300]3EBI-10171534,EBI-18096461
MGST3 [O14880]3EBI-10171534,EBI-724754
MRPS18B [Q9Y676]3EBI-10171534,EBI-750085
MUC1 - isoform Y-LSP [P15941-11]3EBI-10171534,EBI-17263240
NCAPH2 - isoform 4 [Q6IBW4-4]3EBI-10171534,EBI-10247000
REEP2 [Q9BRK0]3EBI-10171534,EBI-11337973
REEP4 [Q9H6H4]3EBI-10171534,EBI-7545592
RETREG3 [Q86VR2]3EBI-10171534,EBI-10192441
RNF19B [Q6ZMZ0]3EBI-10171534,EBI-2466594
RNF5 [Q99942]3EBI-10171534,EBI-348482
SCN3B [Q9NY72]3EBI-10171534,EBI-17247926
SH3GL3 [Q8IVP1]3EBI-10171534,EBI-6503765
SLC10A1 [Q14973]3EBI-10171534,EBI-3923031
SLC10A6 [Q3KNW5]3EBI-10171534,EBI-18159983
SLC17A8 - isoform 2 [Q8NDX2-2]3EBI-10171534,EBI-17249797
SLC18A1 - isoform 3 [P54219-3]3EBI-10171534,EBI-17595455
SLC1A3 [P43003]3EBI-10171534,EBI-359038
STOM [P27105]3EBI-10171534,EBI-1211440
STX2 - isoform 1 [P32856-2]3EBI-10171534,EBI-11956649
TLCD4 [Q96MV1]3EBI-10171534,EBI-12947623
TMEM139 [Q8IV31]3EBI-10171534,EBI-7238458
TMEM143 [Q96AN5]3EBI-10171534,EBI-13342951
TMEM14B [Q9NUH8]3EBI-10171534,EBI-8638294
TMEM80 [Q96HE8]3EBI-10171534,EBI-11742770
TMPRSS2 - isoform 2 [O15393-2]3EBI-10171534,EBI-12345267
TMX2 [Q9Y320]3EBI-10171534,EBI-6447886
ZDHHC15 [Q96MV8]3EBI-10171534,EBI-12837904

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126849, 108 interactors

Protein interaction database and analysis system

More...IntActi		A0PK00, 69 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000404991

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A0PK00, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0PK00

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 77Sequence analysisAdd BLAST77

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM120 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4758, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007848

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_048749_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A0PK00

Identification of Orthologs from Complete Genome Data

More...OMAi		WFNVYIS

Database of Orthologous Groups

More...OrthoDBi		916768at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A0PK00

TreeFam database of animal gene trees

More...TreeFami		TF313552

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012926, TACAN/TMEM120B

The PANTHER Classification System

More...PANTHERi		PTHR21433, PTHR21433, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07851, TMPIT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0PK00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELAALQ TLCSSSISKQ 
        60         70         80         90        100
KKHLKDLKLT LQRCKRHASR EEAELVQQMA ANIKERQDVF FDMEAYLPKK 
       110        120        130        140        150
NGLYLNLVLG NVNVTLLSNQ AKFAYKDEYE KFKLYLTIIL LLGAVACRFV 
       160        170        180        190        200
LHYRVTDEVF NFLLVWYYCT LTIRESILIS NGSRIKGWWV SHHYVSTFLS 
       210        220        230        240        250
GVMLTWPNGP IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC LYRLRALGER 
       260        270        280        290        300
NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE 
       310        320        330 
WQVFVLAFTF LILFLGNFLT TLKVVHAKLQ KNRGKTKQP
Length:339
Mass (Da):40,246
Last modified:January 9, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15A08B563ED261D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YG77H0YG77_HUMAN
Transmembrane protein 120B
TMEM120B
247Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H465F5H465_HUMAN
Transmembrane protein 120B
TMEM120B
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92D → N in AAI27770 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK126568 mRNA Translation: BAG54345.1
BC127768 mRNA Translation: AAI27769.1
BC127769 mRNA Translation: AAI27770.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41852.1

NCBI Reference Sequences

More...RefSeqi		NP_001074294.2, NM_001080825.2
XP_016874342.1, XM_017018853.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000342607; ENSP00000345152; ENSG00000188735
ENST00000449592; ENSP00000404991; ENSG00000188735

Database of genes from NCBI RefSeq genomes

More...GeneIDi		144404

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:144404

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000449592.7; ENSP00000404991.2; NM_001080825.2; NP_001074294.2

UCSC genome browser

More...UCSCi		uc001ubc.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126568 mRNA Translation: BAG54345.1
BC127768 mRNA Translation: AAI27769.1
BC127769 mRNA Translation: AAI27770.1
CCDSiCCDS41852.1
RefSeqiNP_001074294.2, NM_001080825.2
XP_016874342.1, XM_017018853.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7F73electron microscopy4.00A/B1-339[»]
SMRiA0PK00
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi126849, 108 interactors
IntActiA0PK00, 69 interactors
STRINGi9606.ENSP00000404991

PTM databases

iPTMnetiA0PK00
PhosphoSitePlusiA0PK00
SwissPalmiA0PK00

Genetic variation databases

BioMutaiTMEM120B

Proteomic databases

EPDiA0PK00
jPOSTiA0PK00
MassIVEiA0PK00
MaxQBiA0PK00
PaxDbiA0PK00
PeptideAtlasiA0PK00
PRIDEiA0PK00
ProteomicsDBi76

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2742, 41 antibodies from 14 providers

The DNASU plasmid repository

More...DNASUi		144404

Genome annotation databases

EnsembliENST00000342607; ENSP00000345152; ENSG00000188735
ENST00000449592; ENSP00000404991; ENSG00000188735
GeneIDi144404
KEGGihsa:144404
MANE-SelectiENST00000449592.7; ENSP00000404991.2; NM_001080825.2; NP_001074294.2
UCSCiuc001ubc.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		144404
DisGeNETi144404

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM120B
HGNCiHGNC:32008, TMEM120B
HPAiENSG00000188735, Low tissue specificity
MIMi616551, gene
neXtProtiNX_A0PK00
OpenTargetsiENSG00000188735
PharmGKBiPA162405862
VEuPathDBiHostDB:ENSG00000188735

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4758, Eukaryota
GeneTreeiENSGT00390000007848
HOGENOMiCLU_048749_1_1_1
InParanoidiA0PK00
OMAiWFNVYIS
OrthoDBi916768at2759
PhylomeDBiA0PK00
TreeFamiTF313552

Enzyme and pathway databases

PathwayCommonsiA0PK00
SignaLinkiA0PK00

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		144404, 7 hits in 1050 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM120B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		144404
PharosiA0PK00, Tdark

Protein Ontology

More...PROi		PR:A0PK00
RNActiA0PK00, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000188735, Expressed in right hemisphere of cerebellum and 192 other tissues
ExpressionAtlasiA0PK00, baseline and differential
GenevisibleiA0PK00, HS

Family and domain databases

InterProiView protein in InterPro
IPR012926, TACAN/TMEM120B
PANTHERiPTHR21433, PTHR21433, 1 hit
PfamiView protein in Pfam
PF07851, TMPIT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT120B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0PK00
Secondary accession number(s): A0PK01, B3KX33
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 9, 2007
Last modified: February 23, 2022
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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