FEZF1

Functionⁱ

Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity).By similarity

Miscellaneous

Triggers oncogenic activity specifically in gastric tumors through activation of KRAS in the ERK signaling pathway.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	260 – 282	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	288 – 310	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	316 – 338	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	344 – 366	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	372 – 394	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	400 – 423	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axon guidance Source: Ensembl
cell dedifferentiation Source: Ensembl
forebrain anterior/posterior pattern specification Source: Ensembl
negative regulation of cell proliferation Source: Ensembl
neuron migration Source: Ensembl
olfactory bulb development Source: Ensembl
positive regulation of neuron differentiation Source: Ensembl
positive regulation of transcription, DNA-templated Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding, Repressor
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fez family zinc finger protein 1 Alternative name(s): Zinc finger protein 312B
Gene namesⁱ	Name:FEZF1 Synonyms:FEZ, ZNF312B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000128610.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:22788 FEZF1
MIMⁱ	613301 gene
neXtProtⁱ	NX_A0PJY2

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hypogonadotropic hypogonadism 22 with or without anosmia (HH22)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).

Keywords - Diseaseⁱ

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

DisGeNET More...DisGeNETⁱ	389549
MalaCards human disease database More...MalaCardsⁱ	FEZF1
MIMⁱ	616030 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000128610
Orphanetⁱ	478 Kallmann syndrome
PharmGKBⁱ	PA162388419

Polymorphism and mutation databases

BioMutaⁱ	FEZF1

BioMutaⁱ

FEZF1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000295114	1 – 475	Fez family zinc finger protein 1Add BLAST		475

Proteomic databases

PaxDbⁱ	A0PJY2
PRIDEⁱ	A0PJY2
ProteomicsDBⁱ	71 72 [A0PJY2-2] 73 [A0PJY2-3]

PTM databases

iPTMnetⁱ	A0PJY2
PhosphoSitePlusⁱ	A0PJY2

Expressionⁱ

Tissue specificityⁱ

Expressed in brain. Little or no expression in other tissues. Overexpressed specifically in gastric cancers. A 2-to 20-fold increase is found in over 50% of gastric cancer tissues.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000128610 Expressed in 31 organ(s), highest expression level in hypothalamus
CleanExⁱ	HS_FEZF1
ExpressionAtlasⁱ	A0PJY2 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA064639 HPA073693

HPAⁱ

HPA064639
HPA073693

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	133180, 25 interactors
IntActⁱ	A0PJY2, 6 interactors
STRINGⁱ	9606.ENSP00000411145

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A0PJY2
SMRⁱ	A0PJY2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	28 – 43	Engrailed homology 1 repressorBy similarityAdd BLAST		16

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	433 – 468	Pro-richAdd BLAST		36

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	260 – 282	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	288 – 310	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	316 – 338	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	344 – 366	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	372 – 394	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	400 – 423	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00740000115096
HOGENOMⁱ	HOG000013052
HOVERGENⁱ	HBG098441
InParanoidⁱ	A0PJY2
OMAⁱ	CHNATAK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ISJ
PhylomeDBⁱ	A0PJY2
TreeFamⁱ	TF316780

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 5 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 6 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: A0PJY2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSSCHNATT KMLATAPARG NMMSTSKPLA FSIERIMART PEPKALPVPH 
        60         70         80         90        100
FLQGALPKGE PKHSLHLNSS IPCMIPFVPV AYDTSPKAGV TGSEPRKASL 
       110        120        130        140        150
EAPAAPAAVP SAPAFSCSDL LNCALSLKGD LARDALPLQQ YKLVRPRVVN 
       160        170        180        190        200
HSSFHAMGAL CYLNRGDGPC HPAAGVNIHP VASYFLSSPL HPQPKTYLAE 
       210        220        230        240        250
RNKLVVPAVE KYPSGVAFKD LSQAQLQHYM KESAQLLSEK IAFKTSDFSR 
       260        270        280        290        300
GSPNAKPKVF TCEVCGKVFN AHYNLTRHMP VHTGARPFVC KVCGKGFRQA 
       310        320        330        340        350
STLCRHKIIH TQEKPHKCNQ CGKAFNRSST LNTHTRIHAG YKPFVCEFCG 
       360        370        380        390        400
KGFHQKGNYK NHKLTHSGEK QFKCNICNKA FHQVYNLTFH MHTHNDKKPF 
       410        420        430        440        450
TCPTCGKGFC RNFDLKKHVR KLHDSSLGLA RTPAGEPGTE PPPPLPQQPP 
       460        470 
MTLPPLQPPL PTPGPLQPGL HQGHQ

Length:475

Mass (Da):52,038

Last modified:January 9, 2007 - v1

Checksum:ⁱA26945A0C4E9316A

GO

Isoform 2 (identifier: A0PJY2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
144-193: Missing.

« Hide

        10         20         30         40         50
MDSSCHNATT KMLATAPARG NMMSTSKPLA FSIERIMART PEPKALPVPH 
        60         70         80         90        100
FLQGALPKGE PKHSLHLNSS IPCMIPFVPV AYDTSPKAGV TGSEPRKASL 
       110        120        130        140        150
EAPAAPAAVP SAPAFSCSDL LNCALSLKGD LARDALPLQQ YKLPKTYLAE 
       160        170        180        190        200
RNKLVVPAVE KYPSGVAFKD LSQAQLQHYM KESAQLLSEK IAFKTSDFSR 
       210        220        230        240        250
GSPNAKPKVF TCEVCGKVFN AHYNLTRHMP VHTGARPFVC KVCGKGFRQA 
       260        270        280        290        300
STLCRHKIIH TQEKPHKCNQ CGKAFNRSST LNTHTRIHAG YKPFVCEFCG 
       310        320        330        340        350
KGFHQKGNYK NHKLTHSGEK QFKCNICNKA FHQVYNLTFH MHTHNDKKPF 
       360        370        380        390        400
TCPTCGKGFC RNFDLKKHVR KLHDSSLGLA RTPAGEPGTE PPPPLPQQPP 
       410        420 
MTLPPLQPPL PTPGPLQPGL HQGHQ

Note: No experimental confirmation available.

Show »

Length:425

Mass (Da):46,677

Checksum:ⁱBD12C0C98DB12E2A

GO

Isoform 3 (identifier: A0PJY2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
265-268: Missing.

« Hide

        10         20         30         40         50
MDSSCHNATT KMLATAPARG NMMSTSKPLA FSIERIMART PEPKALPVPH 
        60         70         80         90        100
FLQGALPKGE PKHSLHLNSS IPCMIPFVPV AYDTSPKAGV TGSEPRKASL 
       110        120        130        140        150
EAPAAPAAVP SAPAFSCSDL LNCALSLKGD LARDALPLQQ YKLVRPRVVN 
       160        170        180        190        200
HSSFHAMGAL CYLNRGDGPC HPAAGVNIHP VASYFLSSPL HPQPKTYLAE 
       210        220        230        240        250
RNKLVVPAVE KYPSGVAFKD LSQAQLQHYM KESAQLLSEK IAFKTSDFSR 
       260        270        280        290        300
GSPNAKPKVF TCEVFNAHYN LTRHMPVHTG ARPFVCKVCG KGFRQASTLC 
       310        320        330        340        350
RHKIIHTQEK PHKCNQCGKA FNRSSTLNTH TRIHAGYKPF VCEFCGKGFH 
       360        370        380        390        400
QKGNYKNHKL THSGEKQFKC NICNKAFHQV YNLTFHMHTH NDKKPFTCPT 
       410        420        430        440        450
CGKGFCRNFD LKKHVRKLHD SSLGLARTPA GEPGTEPPPP LPQQPPMTLP 
       460        470 
PLQPPLPTPG PLQPGLHQGH Q

Note: Gene prediction based on EST data.

Show »

Length:471

Mass (Da):51,651

Checksum:ⁱFD6569909179F243

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9J0C5	C9J0C5_HUMAN		Fez family zinc finger protein 1 Fez family zinc finger protein 1	FEZF1	35	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_071918	278	H → Y in HH22; partial loss of function. 1 PublicationCorresponds to variant dbSNP:rs587777739EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_026732	144 – 193	Missing in isoform 2. 1 PublicationAdd BLAST		50
Alternative sequenceⁱVSP_026733	265 – 268	Missing in isoform 3. Curated		4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK300742 mRNA Translation: BAG62411.1 CH236947 Genomic DNA Translation: EAL24342.1 BC127714 mRNA Translation: AAI27715.1 BC127715 mRNA Translation: AAI27716.1 BC136684 mRNA Translation: AAI36685.1 BC144367 mRNA Translation: AAI44368.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34741.2 [A0PJY2-1] CCDS55157.1 [A0PJY2-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001019784.2, NM_001024613.3 [A0PJY2-1] NP_001153736.1, NM_001160264.2 [A0PJY2-2] XP_005250394.1, XM_005250337.3 [A0PJY2-1] XP_011514504.1, XM_011516202.2 [A0PJY2-2]
UniGeneⁱ	Hs.553970

Genome annotation databases

Ensemblⁱ	ENST00000427185; ENSP00000392727; ENSG00000128610 [A0PJY2-2] ENST00000442488; ENSP00000411145; ENSG00000128610 [A0PJY2-1]
GeneIDⁱ	389549
KEGGⁱ	hsa:389549
UCSC genome browser More...UCSCⁱ	uc003vkc.4 human [A0PJY2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
A0PJY2	Fez family zinc finger protein 1		MOUSE		475	UniRef90_Q0VDQ9
Fez family zinc finger protein 1		HETGA		479
FEZ family zinc finger 1		HORSE		478
FEZ family zinc finger 1		BOVIN		476
FEZ family zinc finger 1		RABIT		476
+82
A0PJY2-2	fez family zinc finger protein 1 isoform X2		Enhydra lutris kenyoni		425	UniRef90_A0PJY2-2
Uncharacterized protein		RHIRO		425
Uncharacterized protein		PROCO		425
FEZF1 isoform 3		PONAB		425
FEZ family zinc finger 1		SAIBB		425
+66
A0PJY2-3	Fez family zinc finger protein 1		FUKDA		577	UniRef90_A0PJY2-3
fez family zinc finger protein 1		BALAS		471
FEZ family zinc finger 1		PONAB		471
Uncharacterized protein		OTOGA		470
fez family zinc finger protein 1 isoform X1		Florida manatee		470
+11

Protein	Similar proteins		Species	Score	Length	Source
A0PJY2	Fez family zinc finger protein 1		MOUSE		475	UniRef50_Q0VDQ9
Fez family zinc finger protein 1		HETGA		479
FEZ family zinc finger 1		HORSE		478
FEZ family zinc finger 1		BOVIN		476
FEZ family zinc finger 1		RABIT		476
+154
A0PJY2-2	Fez family zinc finger protein 1		XENLA		466	UniRef50_A0PJY2-2
Fez family zinc finger protein 1		XENTR		462
Fez family zinc finger protein 1		DANRE		429
fez family zinc finger protein 1 isoform X2		ODORO		425
Uncharacterized protein		CERAT		425
+136

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK300742 mRNA Translation: BAG62411.1 CH236947 Genomic DNA Translation: EAL24342.1 BC127714 mRNA Translation: AAI27715.1 BC127715 mRNA Translation: AAI27716.1 BC136684 mRNA Translation: AAI36685.1 BC144367 mRNA Translation: AAI44368.1
CCDSⁱ	CCDS34741.2 [A0PJY2-1] CCDS55157.1 [A0PJY2-2]
RefSeqⁱ	NP_001019784.2, NM_001024613.3 [A0PJY2-1] NP_001153736.1, NM_001160264.2 [A0PJY2-2] XP_005250394.1, XM_005250337.3 [A0PJY2-1] XP_011514504.1, XM_011516202.2 [A0PJY2-2]
UniGeneⁱ	Hs.553970

3D structure databases

ProteinModelPortalⁱ	A0PJY2
SMRⁱ	A0PJY2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	133180, 25 interactors
IntActⁱ	A0PJY2, 6 interactors
STRINGⁱ	9606.ENSP00000411145

PTM databases

iPTMnetⁱ	A0PJY2
PhosphoSitePlusⁱ	A0PJY2

Polymorphism and mutation databases

BioMutaⁱ	FEZF1

BioMutaⁱ

FEZF1

Proteomic databases

PaxDbⁱ	A0PJY2
PRIDEⁱ	A0PJY2
ProteomicsDBⁱ	71 72 [A0PJY2-2] 73 [A0PJY2-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000427185; ENSP00000392727; ENSG00000128610 [A0PJY2-2] ENST00000442488; ENSP00000411145; ENSG00000128610 [A0PJY2-1]
GeneIDⁱ	389549
KEGGⁱ	hsa:389549
UCSCⁱ	uc003vkc.4 human [A0PJY2-1]

Organism-specific databases

CTDⁱ	389549
DisGeNETⁱ	389549
EuPathDBⁱ	HostDB:ENSG00000128610.11
GeneCardsⁱ	FEZF1
HGNCⁱ	HGNC:22788 FEZF1
HPAⁱ	HPA064639 HPA073693
MalaCardsⁱ	FEZF1
MIMⁱ	613301 gene 616030 phenotype
neXtProtⁱ	NX_A0PJY2
OpenTargetsⁱ	ENSG00000128610
Orphanetⁱ	478 Kallmann syndrome
PharmGKBⁱ	PA162388419
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00740000115096
HOGENOMⁱ	HOG000013052
HOVERGENⁱ	HBG098441
InParanoidⁱ	A0PJY2
OMAⁱ	CHNATAK
OrthoDBⁱ	EOG091G0ISJ
PhylomeDBⁱ	A0PJY2
TreeFamⁱ	TF316780

Miscellaneous databases

GenomeRNAiⁱ	389549
Protein Ontology More...PROⁱ	PR:A0PJY2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000128610 Expressed in 31 organ(s), highest expression level in hypothalamus
CleanExⁱ	HS_FEZF1
ExpressionAtlasⁱ	A0PJY2 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 5 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 6 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FEZF1_HUMAN
Accessionⁱ	A0PJY2Primary (citable) accession number: A0PJY2 Secondary accession number(s): A0PJY3 , A4D0W3, B4DUP9, B7ZM98
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
	Last sequence update:	January 9, 2007
	Last modified:	November 7, 2018
	This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - A0PJY2 (FEZF1_HUMAN)

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Fez family zinc finger protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ