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Protein

Calcium and integrin-binding family member 4

Gene

CIB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

The binding of either calcium or magnesium may significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi110 – 1211PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi152 – 1632PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB

Keywordsi

LigandCalcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium and integrin-binding family member 4
Gene namesi
Name:CIB4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000157884.10
HGNCiHGNC:33703 CIB4
MIMi610646 gene
neXtProtiNX_A0PJX0

Pathology & Biotechi

Organism-specific databases

DisGeNETi130106
OpenTargetsiENSG00000157884
PharmGKBiPA162382288

Polymorphism and mutation databases

BioMutaiCIB4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892901 – 185Calcium and integrin-binding family member 4Add BLAST185

Proteomic databases

PaxDbiA0PJX0
PRIDEiA0PJX0
ProteomicsDBi66

PTM databases

iPTMnetiA0PJX0
PhosphoSitePlusiA0PJX0

Expressioni

Gene expression databases

BgeeiENSG00000157884 Expressed in 70 organ(s), highest expression level in right testis
CleanExiHS_CIB4
GenevisibleiA0PJX0 HS

Organism-specific databases

HPAiHPA036130
HPA036131

Interactioni

Subunit structurei

Interacts with ITGA2B (via C-terminus cytoplasmic tail region); the interaction is stabilized/increased in a calcium- and magnesium-dependent manner.1 Publication

Protein-protein interaction databases

BioGridi126223, 2 interactors
IntActiA0PJX0, 7 interactors
STRINGi9606.ENSP00000288861

Structurei

3D structure databases

ProteinModelPortaliA0PJX0
SMRiA0PJX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 95EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini97 – 132EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini138 – 174EF-hand 3PROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0034 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00860000133737
HOGENOMiHOG000233019
HOVERGENiHBG107344
InParanoidiA0PJX0
OMAiVFSHNNV
OrthoDBiEOG091G0OJZ
PhylomeDBiA0PJX0
TreeFamiTF313865

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

A0PJX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQCLRYQMH WEDLEEYQAL TFLTRNEILC IHDTFLKLCP PGKYYKEATL
60 70 80 90 100
TMDQVSSLPA LRVNPFRDRI CRVFSHKGMF SFEDVLGMAS VFSEQACPSL
110 120 130 140 150
KIEYAFRIYD FNENGFIDEE DLQRIILRLL NSDDMSEDLL MDLTNHVLSE
160 170 180
SDLDNDNMLS FSEFEHAMAK SPDFMNSFRI HFWGC
Length:185
Mass (Da):21,745
Last modified:January 9, 2007 - v1
Checksum:iA0DB9D75BF8F9724
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048637181H → R2 PublicationsCorresponds to variant dbSNP:rs935172Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471053 Genomic DNA Translation: EAX00680.1
BC127684 mRNA Translation: AAI27685.1
BC127685 mRNA Translation: AAI27686.1
BC140923 mRNA Translation: AAI40924.1
CCDSiCCDS33160.1
RefSeqiNP_001025052.1, NM_001029881.2
UniGeneiHs.591579

Genome annotation databases

EnsembliENST00000288861; ENSP00000288861; ENSG00000157884
GeneIDi130106
KEGGihsa:130106
UCSCiuc002rhm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471053 Genomic DNA Translation: EAX00680.1
BC127684 mRNA Translation: AAI27685.1
BC127685 mRNA Translation: AAI27686.1
BC140923 mRNA Translation: AAI40924.1
CCDSiCCDS33160.1
RefSeqiNP_001025052.1, NM_001029881.2
UniGeneiHs.591579

3D structure databases

ProteinModelPortaliA0PJX0
SMRiA0PJX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126223, 2 interactors
IntActiA0PJX0, 7 interactors
STRINGi9606.ENSP00000288861

PTM databases

iPTMnetiA0PJX0
PhosphoSitePlusiA0PJX0

Polymorphism and mutation databases

BioMutaiCIB4

Proteomic databases

PaxDbiA0PJX0
PRIDEiA0PJX0
ProteomicsDBi66

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288861; ENSP00000288861; ENSG00000157884
GeneIDi130106
KEGGihsa:130106
UCSCiuc002rhm.4 human

Organism-specific databases

CTDi130106
DisGeNETi130106
EuPathDBiHostDB:ENSG00000157884.10
GeneCardsiCIB4
HGNCiHGNC:33703 CIB4
HPAiHPA036130
HPA036131
MIMi610646 gene
neXtProtiNX_A0PJX0
OpenTargetsiENSG00000157884
PharmGKBiPA162382288
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0034 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00860000133737
HOGENOMiHOG000233019
HOVERGENiHBG107344
InParanoidiA0PJX0
OMAiVFSHNNV
OrthoDBiEOG091G0OJZ
PhylomeDBiA0PJX0
TreeFamiTF313865

Miscellaneous databases

GenomeRNAii130106
PROiPR:A0PJX0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157884 Expressed in 70 organ(s), highest expression level in right testis
CleanExiHS_CIB4
GenevisibleiA0PJX0 HS

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCIB4_HUMAN
AccessioniPrimary (citable) accession number: A0PJX0
Secondary accession number(s): B2RU18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 9, 2007
Last modified: September 12, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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