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Protein

Transmembrane protein 223

Gene

TMEM223

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 223
Gene namesi
Name:TMEM223
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000168569.7
HGNCiHGNC:28464 TMEM223
neXtProtiNX_A0PJW6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168569
PharmGKBiPA164726538

Polymorphism and mutation databases

BioMutaiTMEM223

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003218331 – 202Transmembrane protein 223Add BLAST202

Proteomic databases

EPDiA0PJW6
MaxQBiA0PJW6
PaxDbiA0PJW6
PRIDEiA0PJW6
ProteomicsDBi64

PTM databases

iPTMnetiA0PJW6
PhosphoSitePlusiA0PJW6

Expressioni

Gene expression databases

BgeeiENSG00000168569 Expressed in 97 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiA0PJW6 baseline and differential
GenevisibleiA0PJW6 HS

Organism-specific databases

HPAiHPA014504

Interactioni

Protein-protein interaction databases

BioGridi122517, 33 interactors
IntActiA0PJW6, 2 interactors
STRINGi9606.ENSP00000303987

Structurei

3D structure databases

ProteinModelPortaliA0PJW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM223 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWJD Eukaryota
ENOG4111M6M LUCA
GeneTreeiENSGT00390000012589
HOGENOMiHOG000008386
InParanoidiA0PJW6
OMAiNGITICS
OrthoDBiEOG091G0W7I
PhylomeDBiA0PJW6
TreeFamiTF324862

Family and domain databases

InterProiView protein in InterPro
IPR026100 Tmem223
PANTHERiPTHR14549 PTHR14549, 1 hit
PfamiView protein in Pfam
PF14640 TMEM223, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

A0PJW6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPWRRWPT GLLAVLRPLL TCRPLQGTTL QRDVLLFEHD RGRFFTILGL
60 70 80 90 100
FCAGQGVFWA SMAVAAVSRP PVPVQPLDAE VPNRGPFDLR SALWRYGLAV
110 120 130 140 150
GCGAIGALVL GAGLLFSLRS VRSVVLRAGG QQVTLTTHAP FGLGAHFTVP
160 170 180 190 200
LKQVSCMAHR GEVPAMLPLK VKGRRFYFLL DKTGHFPNTK LFDNTVGAYR

SL
Length:202
Mass (Da):22,049
Last modified:January 9, 2007 - v1
Checksum:iA233432FF880DAAC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCK4H0YCK4_HUMAN
Transmembrane protein 223
TMEM223
137Annotation score:
G5EA27G5EA27_HUMAN
HCG2039995, isoform CRA_a
TMEM223 hCG_2039995
106Annotation score:

Sequence cautioni

The sequence AAH20914 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175R → S in AAH42801 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03935728T → A1 PublicationCorresponds to variant dbSNP:rs2584918Ensembl.1
Natural variantiVAR_039358196V → G. Corresponds to variant dbSNP:rs11827177Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA Translation: EAW74102.1
BC008643 mRNA Translation: AAH08643.1
BC020914 mRNA Translation: AAH20914.1 Different initiation.
BC042801 mRNA Translation: AAH42801.1
BC094837 mRNA Translation: AAH94837.1
BC127679 mRNA Translation: AAI27680.1
CCDSiCCDS44628.1
RefSeqiNP_001073970.1, NM_001080501.2
UniGeneiHs.530463

Genome annotation databases

EnsembliENST00000307366; ENSP00000303987; ENSG00000168569
GeneIDi79064
KEGGihsa:79064
UCSCiuc001nve.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA Translation: EAW74102.1
BC008643 mRNA Translation: AAH08643.1
BC020914 mRNA Translation: AAH20914.1 Different initiation.
BC042801 mRNA Translation: AAH42801.1
BC094837 mRNA Translation: AAH94837.1
BC127679 mRNA Translation: AAI27680.1
CCDSiCCDS44628.1
RefSeqiNP_001073970.1, NM_001080501.2
UniGeneiHs.530463

3D structure databases

ProteinModelPortaliA0PJW6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122517, 33 interactors
IntActiA0PJW6, 2 interactors
STRINGi9606.ENSP00000303987

PTM databases

iPTMnetiA0PJW6
PhosphoSitePlusiA0PJW6

Polymorphism and mutation databases

BioMutaiTMEM223

Proteomic databases

EPDiA0PJW6
MaxQBiA0PJW6
PaxDbiA0PJW6
PRIDEiA0PJW6
ProteomicsDBi64

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307366; ENSP00000303987; ENSG00000168569
GeneIDi79064
KEGGihsa:79064
UCSCiuc001nve.3 human

Organism-specific databases

CTDi79064
EuPathDBiHostDB:ENSG00000168569.7
GeneCardsiTMEM223
H-InvDBiHIX0035957
HGNCiHGNC:28464 TMEM223
HPAiHPA014504
neXtProtiNX_A0PJW6
OpenTargetsiENSG00000168569
PharmGKBiPA164726538
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWJD Eukaryota
ENOG4111M6M LUCA
GeneTreeiENSGT00390000012589
HOGENOMiHOG000008386
InParanoidiA0PJW6
OMAiNGITICS
OrthoDBiEOG091G0W7I
PhylomeDBiA0PJW6
TreeFamiTF324862

Miscellaneous databases

ChiTaRSiTMEM223 human
GenomeRNAii79064
PROiPR:A0PJW6

Gene expression databases

BgeeiENSG00000168569 Expressed in 97 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiA0PJW6 baseline and differential
GenevisibleiA0PJW6 HS

Family and domain databases

InterProiView protein in InterPro
IPR026100 Tmem223
PANTHERiPTHR14549 PTHR14549, 1 hit
PfamiView protein in Pfam
PF14640 TMEM223, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM223_HUMAN
AccessioniPrimary (citable) accession number: A0PJW6
Secondary accession number(s): Q504S0
, Q86YD4, Q8WUC5, Q96HG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: September 12, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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