UniProtKB - A0PJW6 (TM223_HUMAN)
Protein
Transmembrane protein 223
Gene
TMEM223
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- nervous system development Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | A0PJW6 |
Protein family/group databases
TCDBi | 8.A.115.1.1, the transmembrane protein 223 (tmem223) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 223 |
Gene namesi | Name:TMEM223 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28464, TMEM223 |
neXtProti | NX_A0PJW6 |
VEuPathDBi | HostDB:ENSG00000168569.7 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 44 – 64 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000168569 |
PharmGKBi | PA164726538 |
Miscellaneous databases
Pharosi | A0PJW6, Tdark |
Genetic variation databases
BioMutai | TMEM223 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000321833 | 1 – 202 | Transmembrane protein 223Add BLAST | 202 |
Proteomic databases
EPDi | A0PJW6 |
jPOSTi | A0PJW6 |
MassIVEi | A0PJW6 |
MaxQBi | A0PJW6 |
PaxDbi | A0PJW6 |
PeptideAtlasi | A0PJW6 |
PRIDEi | A0PJW6 |
ProteomicsDBi | 64 |
PTM databases
iPTMneti | A0PJW6 |
PhosphoSitePlusi | A0PJW6 |
SwissPalmi | A0PJW6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168569, Expressed in muscle tissue and 120 other tissues |
ExpressionAtlasi | A0PJW6, baseline and differential |
Genevisiblei | A0PJW6, HS |
Organism-specific databases
HPAi | ENSG00000168569, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122517, 36 interactors |
IntActi | A0PJW6, 34 interactors |
STRINGi | 9606.ENSP00000303987 |
Miscellaneous databases
RNActi | A0PJW6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM223 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S0RN, Eukaryota |
GeneTreei | ENSGT00390000012589 |
HOGENOMi | CLU_099187_0_0_1 |
InParanoidi | A0PJW6 |
OMAi | ACHAHRQ |
OrthoDBi | 1478337at2759 |
PhylomeDBi | A0PJW6 |
TreeFami | TF324862 |
Family and domain databases
InterProi | View protein in InterPro IPR026100, Tmem223 |
PANTHERi | PTHR14549, PTHR14549, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A0PJW6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPWRRWPT GLLAVLRPLL TCRPLQGTTL QRDVLLFEHD RGRFFTILGL
60 70 80 90 100
FCAGQGVFWA SMAVAAVSRP PVPVQPLDAE VPNRGPFDLR SALWRYGLAV
110 120 130 140 150
GCGAIGALVL GAGLLFSLRS VRSVVLRAGG QQVTLTTHAP FGLGAHFTVP
160 170 180 190 200
LKQVSCMAHR GEVPAMLPLK VKGRRFYFLL DKTGHFPNTK LFDNTVGAYR
SL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5EA27 | G5EA27_HUMAN | HCG2039995, isoform CRA_a | TMEM223 hCG_2039995 | 106 | Annotation score: | ||
H0YCK4 | H0YCK4_HUMAN | Transmembrane protein 223 | TMEM223 | 137 | Annotation score: |
Sequence cautioni
The sequence AAH20914 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 175 | R → S in AAH42801 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039357 | 28 | T → A1 PublicationCorresponds to variant dbSNP:rs2584918Ensembl. | 1 | |
Natural variantiVAR_039358 | 196 | V → G. Corresponds to variant dbSNP:rs11827177Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471076 Genomic DNA Translation: EAW74102.1 BC008643 mRNA Translation: AAH08643.1 BC020914 mRNA Translation: AAH20914.1 Different initiation. BC042801 mRNA Translation: AAH42801.1 BC094837 mRNA Translation: AAH94837.1 BC127679 mRNA Translation: AAI27680.1 |
CCDSi | CCDS44628.1 |
RefSeqi | NP_001073970.1, NM_001080501.2 |
Genome annotation databases
Ensembli | ENST00000307366; ENSP00000303987; ENSG00000168569 |
GeneIDi | 79064 |
KEGGi | hsa:79064 |
UCSCi | uc001nve.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471076 Genomic DNA Translation: EAW74102.1 BC008643 mRNA Translation: AAH08643.1 BC020914 mRNA Translation: AAH20914.1 Different initiation. BC042801 mRNA Translation: AAH42801.1 BC094837 mRNA Translation: AAH94837.1 BC127679 mRNA Translation: AAI27680.1 |
CCDSi | CCDS44628.1 |
RefSeqi | NP_001073970.1, NM_001080501.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122517, 36 interactors |
IntActi | A0PJW6, 34 interactors |
STRINGi | 9606.ENSP00000303987 |
Protein family/group databases
TCDBi | 8.A.115.1.1, the transmembrane protein 223 (tmem223) family |
PTM databases
iPTMneti | A0PJW6 |
PhosphoSitePlusi | A0PJW6 |
SwissPalmi | A0PJW6 |
Genetic variation databases
BioMutai | TMEM223 |
Proteomic databases
EPDi | A0PJW6 |
jPOSTi | A0PJW6 |
MassIVEi | A0PJW6 |
MaxQBi | A0PJW6 |
PaxDbi | A0PJW6 |
PeptideAtlasi | A0PJW6 |
PRIDEi | A0PJW6 |
ProteomicsDBi | 64 |
Protocols and materials databases
Antibodypediai | 3050, 8 antibodies |
Genome annotation databases
Ensembli | ENST00000307366; ENSP00000303987; ENSG00000168569 |
GeneIDi | 79064 |
KEGGi | hsa:79064 |
UCSCi | uc001nve.3, human |
Organism-specific databases
CTDi | 79064 |
GeneCardsi | TMEM223 |
HGNCi | HGNC:28464, TMEM223 |
HPAi | ENSG00000168569, Low tissue specificity |
neXtProti | NX_A0PJW6 |
OpenTargetsi | ENSG00000168569 |
PharmGKBi | PA164726538 |
VEuPathDBi | HostDB:ENSG00000168569.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S0RN, Eukaryota |
GeneTreei | ENSGT00390000012589 |
HOGENOMi | CLU_099187_0_0_1 |
InParanoidi | A0PJW6 |
OMAi | ACHAHRQ |
OrthoDBi | 1478337at2759 |
PhylomeDBi | A0PJW6 |
TreeFami | TF324862 |
Enzyme and pathway databases
PathwayCommonsi | A0PJW6 |
Miscellaneous databases
BioGRID-ORCSi | 79064, 4 hits in 878 CRISPR screens |
ChiTaRSi | TMEM223, human |
GenomeRNAii | 79064 |
Pharosi | A0PJW6, Tdark |
PROi | PR:A0PJW6 |
RNActi | A0PJW6, protein |
Gene expression databases
Bgeei | ENSG00000168569, Expressed in muscle tissue and 120 other tissues |
ExpressionAtlasi | A0PJW6, baseline and differential |
Genevisiblei | A0PJW6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026100, Tmem223 |
PANTHERi | PTHR14549, PTHR14549, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM223_HUMAN | |
Accessioni | A0PJW6Primary (citable) accession number: A0PJW6 Secondary accession number(s): Q504S0 Q96HG0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | January 9, 2007 | |
Last modified: | February 10, 2021 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families