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Entry version 82 (11 Dec 2019)
Sequence version 1 (09 Jan 2007)
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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

Cacna1c

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cacna1cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

Rat genome database

More...
RGDi
2245 Cacna1c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei121 – 138HelicalSequence analysisAdd BLAST18
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei190 – 208HelicalSequence analysisAdd BLAST19
Transmembranei261 – 283HelicalSequence analysisAdd BLAST23
Transmembranei342 – 363HelicalSequence analysisAdd BLAST22
Transmembranei375 – 397HelicalSequence analysisAdd BLAST23
Transmembranei543 – 561HelicalSequence analysisAdd BLAST19
Transmembranei669 – 691HelicalSequence analysisAdd BLAST23
Transmembranei745 – 771HelicalSequence analysisAdd BLAST27
Transmembranei919 – 938HelicalSequence analysisAdd BLAST20
Transmembranei950 – 972HelicalSequence analysisAdd BLAST23
Transmembranei992 – 1015HelicalSequence analysisAdd BLAST24
Transmembranei1036 – 1069HelicalSequence analysisAdd BLAST34
Transmembranei1161 – 1187HelicalSequence analysisAdd BLAST27
Transmembranei1238 – 1259HelicalSequence analysisAdd BLAST22
Transmembranei1271 – 1291HelicalSequence analysisAdd BLAST21
Transmembranei1377 – 1395HelicalSequence analysisAdd BLAST19
Transmembranei1471 – 1494HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1628 – 1662Ca_chan_IQInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni66 – 91DisorderedSequence analysisAdd BLAST26
Regioni441 – 464DisorderedSequence analysisAdd BLAST24
Regioni782 – 879DisorderedSequence analysisAdd BLAST98
Regioni1750 – 1782DisorderedSequence analysisAdd BLAST33
Regioni1959 – 1987DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1589 – 1609Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi449 – 464PolyampholyteSequence analysisAdd BLAST16
Compositional biasi782 – 827PolyampholyteSequence analysisAdd BLAST46
Compositional biasi844 – 860PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1966 – 1981Pro-richSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301 Eukaryota
ENOG410XNP6 LUCA

Database of Orthologous Groups

More...
OrthoDBi
172471at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031688 CAC1F_C
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005451 VDCC_L_a1csu
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16885 CAC1F_C, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167 CACHANNEL
PR01630 LVDCCALPHA1
PR01635 LVDCCALPHA1C

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062 Ca_chan_IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0PJ39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCCALDCAC SNYGSPRPAH ANMNANAAAG LAPEHIPTPG AALSWQAAID
60 70 80 90 100
AARQAKLMGS AGNATISTVS STQRKRQQYG KPKKQGGTTA TRPPRALLCL
110 120 130 140 150
TLKNPIRRAC ISIVEWKPFE IIILLTIFAN CVALAIYIPF PEDDSNATNS
160 170 180 190 200
NLERVEYLFL IIFTVEAFLK VIAYGLLFHP NAYLRNGWNL LDFIIVVVGL
210 220 230 240 250
FSAILEQATK ADGANALGGK GAGFDVKALR AFRVLRPLRL VSGVPSLQVV
260 270 280 290 300
LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFMGKMHKT CYNQEGIIDV
310 320 330 340 350
PAEEDPSPCA LETGHGRQCQ NGTVCKPGWD GPKHGITNFD NFAFAMLTVF
360 370 380 390 400
QCITMEGWTD VLYWVNDAVG RDWPWIYFVT LIIIGSFFVL NLVLGVLSGE
410 420 430 440 450
FSKEREKAKA RGDFQKLREK QQLEEDLKGY LDWITQAEDI DPENEDEGMD
460 470 480 490 500
EDKPRNRGAP AGLHDQKKGK FAWFSHSTET HVSMPTSETE SVNTENVAGG
510 520 530 540 550
DIEGENCGAR LAHRISKSKF SRYWRRWNRF CRRKCRAAVK SNVFYWLVIF
560 570 580 590 600
LVFLNTLTIA SEHYNQPHWL TEVQDTANKA LLALFTAEML LKMYSLGLQA
610 620 630 640 650
YFVSLFNRFD CFIVCGGILE TILVETKIMS PLGISVLRCV RLLRIFKITR
660 670 680 690 700
YWNSLSNLVA SLLNSVRSIA SLLLLLFLFI IIFSLLGMQL FGGKFNFDEM
710 720 730 740 750
QTRRSTFDNF PQSLLTVFQI LTGEDWNSVM YDGIMAYGGP SFPGMLVCIY
760 770 780 790 800
FIILFICGNY ILLNVFLAIA VDNLADAESL TSAQKEEEEE KERKKLARTA
810 820 830 840 850
SPEKKQEVME KPAVEESKEE KIELKSITAD GESPPTTKIN MDDLQPSENE
860 870 880 890 900
DKSPHSNPDT AGEEDEEEPE MPVGPRPRPL SELHLKEKAV PMPEASAFFI
910 920 930 940 950
FSPNNRFRLQ CHRIVNDTIF TNLILFFILL SSISLAAEDP VQHTSFRNHI
960 970 980 990 1000
LFYFDIVFTT IFTIEIALKM TAYGAFLHKG SFCRNYFNIL DLLVVSVSLI
1010 1020 1030 1040 1050
SFGIQSSAIN VVKILRVLRV LRPLRAINRA KGLKHVVQCV FVAIRTIGNI
1060 1070 1080 1090 1100
VIVTTLLQFM FACIGVQLFK GKLYTCSDSS KQTEAECKGN YITYKDGEVD
1110 1120 1130 1140 1150
HPIIQPRSWE NSKFDFDNVL AAMMALFTVS TFEGWPELLY RSIDSHTEDK
1160 1170 1180 1190 1200
GPIYNYRVEI SIFFIIYIII IAFFMMNIFV GFVIVTFQEQ GEQEYKNCEL
1210 1220 1230 1240 1250
DKNQRQCVEY ALKARPLRRY IPKNQHQYKV WYVVNSTYFE YLMFVLILLN
1260 1270 1280 1290 1300
TICLAMQHYG QSCLFKIAMN ILNMLFTGLF TVEMILKLIA FKPKHYFCDA
1310 1320 1330 1340 1350
WNTFDALIVV GSIVDIAITE VHPAEHTQCS PSMSAEENSR ISITFFRLFR
1360 1370 1380 1390 1400
VMRLVKLLSR GEGIRTLLWT FIKSFQALPY VALLIVMLFF IYAVIGMQVF
1410 1420 1430 1440 1450
GKIALNDTTE INRNNNFQTF PQAVLLLFRC ATGEAWQDIM LACMPGKKCA
1460 1470 1480 1490 1500
PESEPSNSTE GETPCGSSFA VFYFISFYML CAFLIINLFV AVIMDNFDYL
1510 1520 1530 1540 1550
TRDWSILGPH HLDEFKRIWA EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK
1560 1570 1580 1590 1600
LCPHRVACKR LVSMNMPLNS DGTVMFNATL FALVRTALRI KTEGNLEQAN
1610 1620 1630 1640 1650
EELRAIIKKI WKRTSMKLLD QVVPPAGDDE VTVGKFYATF LIQEYFRKFK
1660 1670 1680 1690 1700
KRKEQGLVGK PSQRNALSLQ AGLRTLHDIG PEIRRAISGD LTAEEELDKA
1710 1720 1730 1740 1750
MKEAVSAASE DDIFRRAGGL FGNHVSYYQS DSRSNFPQTF ATQRPLHINK
1760 1770 1780 1790 1800
TGNNQADTES PSHEKLVDST FTPSSYSSTG SNANINNANN TALGRFPHPA
1810 1820 1830 1840 1850
GYSSTVSTVE GHGPPLSPAV RVQEAAWKLS SKRCHSRESQ GATVSQDMFP
1860 1870 1880 1890 1900
DETRSSVRLS EEVEYCSEPS LLSTDILSYQ DDENRQLTCL EEDKREIQPS
1910 1920 1930 1940 1950
PKRSFLRSAS LGRRASFHLE CLKRQKDQGG DISQKTALPL HLVHHQALAV
1960 1970 1980 1990 2000
AGLSPLLQRS HSPSTFPRPR PTPPVTPGSR GRPLQPIPTL RLEGAESSEK
2010 2020 2030 2040 2050
LNSSFPSIHC SSWSEETTAC SGGSSMARRA RPVSLTVPSQ AGAPGRQFHG
2060 2070 2080 2090 2100
SASSLVEAVL ISEGLGQFAQ DPKFIEVTTQ ELADACDMTI EEMENAADNI
2110 2120 2130 2140 2150
LSGGAQQSPN GTLLPFVNCR DPGQDRAVVP EDESCVYALG RGRSEEALPD

SRSYVSNL
Length:2,158
Mass (Da):242,054
Last modified:January 9, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB048D25653DEB601
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY974797 mRNA Translation: AAY42392.1

NCBI Reference Sequences

More...
RefSeqi
XP_008761438.1, XM_008763216.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24239

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY974797 mRNA Translation: AAY42392.1
RefSeqiXP_008761438.1, XM_008763216.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi24239

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
775
RGDi2245 Cacna1c

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
OrthoDBi172471at2759

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031688 CAC1F_C
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005451 VDCC_L_a1csu
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16885 CAC1F_C, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01630 LVDCCALPHA1
PR01635 LVDCCALPHA1C
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0PJ39_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0PJ39
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: December 11, 2019
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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