UniProtKB - A0N0X8 (A0N0X8_HUMAN)
Protein
Cytochrome P450
Gene
CYP1A1
Organism
Homo sapiens (Human)
Status
Functioni
Cytochromes P450 are a group of heme-thiolate monooxygenases.UniRule annotation
Catalytic activityi
- an alkane + O2 + reduced [NADPH—hemoprotein reductase] = a primary alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]UniRule annotationEC:1.14.14.1UniRule annotation
Cofactori
hemeUniRule annotation
GO - Molecular functioni
- aromatase activity Source: UniProtKB-EC
- demethylase activity Source: Ensembl
- enzyme binding Source: Ensembl
- flavonoid 3'-monooxygenase activity Source: Ensembl
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- oxidoreductase activity, acting on diphenols and related substances as donors Source: Ensembl
- steroid hydroxylase activity Source: Ensembl
GO - Biological processi
- 9-cis-retinoic acid biosynthetic process Source: Ensembl
- aging Source: Ensembl
- amine metabolic process Source: Ensembl
- camera-type eye development Source: Ensembl
- cell population proliferation Source: Ensembl
- cellular response to copper ion Source: Ensembl
- coumarin metabolic process Source: Ensembl
- dibenzo-p-dioxin catabolic process Source: Ensembl
- digestive tract development Source: Ensembl
- flavonoid metabolic process Source: Ensembl
- hepatocyte differentiation Source: Ensembl
- hydrogen peroxide biosynthetic process Source: Ensembl
- insecticide metabolic process Source: Ensembl
- maternal process involved in parturition Source: Ensembl
- porphyrin-containing compound metabolic process Source: Ensembl
- positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
- response to antibiotic Source: Ensembl
- response to arsenic-containing substance Source: Ensembl
- response to drug Source: Ensembl
- response to food Source: Ensembl
- response to herbicide Source: Ensembl
- response to hyperoxia Source: Ensembl
- response to hypoxia Source: Ensembl
- response to immobilization stress Source: Ensembl
- response to iron(III) ion Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to nematode Source: Ensembl
- response to organic cyclic compound Source: Ensembl
- response to virus Source: Ensembl
- response to vitamin A Source: Ensembl
- response to wounding Source: Ensembl
Keywordsi
Molecular function | MonooxygenaseUniRule annotation, Oxidoreductase |
Ligand | HemeUniRule annotation, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CYP1A1Imported ORF Names:hCG_40803Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000140465.13 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane UniRule annotation
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: Ensembl
Keywords - Cellular componenti
Endoplasmic reticulum, MicrosomeUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000140465 Expressed in 111 organ(s), highest expression level in liver |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG0156 Eukaryota COG2124 LUCA |
HOVERGENi | HBG106944 |
KOi | K07408 |
OMAi | WEKCLVE |
OrthoDBi | 702827at2759 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008066 Cyt_P450_E_grp-I_CYP1 IPR036396 Cyt_P450_sf |
Pfami | View protein in Pfam PF00067 p450, 1 hit |
PRINTSi | PR00463 EP450I PR01683 EP450ICYP1A PR00385 P450 |
SUPFAMi | SSF48264 SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
A0N0X8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG
60 70 80 90 100
HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG
110 120 130 140 150
DDFKGRPDLY TFTLISNGQS MSFSPDSGPV WAARRRLAQN GLKSFSIASD
160 170 180 190 200
PASSTSCYLE EHVSKEAEVL ISTLQELMAG PGHFNPYRYV VVSVTNVICA
210 220 230 240 250
ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL RYLPNPSLNA
260 270 280 290 300
FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV
310 320 330 340 350
QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV
360 370 380 390 400
IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY
410 420 430 440 450
IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFLTPDGAID KVLSEKVIIF
460 470 480 490 500
GMGKRKCIGE TIARWEVFLF LAILLQRVEF SVPLGVKVDM TPIYGLTMKH
510
ACCEHFQMQL RS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF094025 Genomic DNA Translation: ABK41999.1 AK313880 mRNA Translation: BAG36606.1 CH471136 Genomic DNA Translation: EAW99314.1 CH471136 Genomic DNA Translation: EAW99315.1 |
RefSeqi | NP_000490.1, NM_000499.4 NP_001306146.1, NM_001319217.1 |
UniGenei | Hs.72912 |
Genome annotation databases
GeneIDi | 1543 |
KEGGi | hsa:1543 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF094025 Genomic DNA Translation: ABK41999.1 AK313880 mRNA Translation: BAG36606.1 CH471136 Genomic DNA Translation: EAW99314.1 CH471136 Genomic DNA Translation: EAW99315.1 |
RefSeqi | NP_000490.1, NM_000499.4 NP_001306146.1, NM_001319217.1 |
UniGenei | Hs.72912 |
3D structure databases
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
DNASUi | 1543 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
GeneIDi | 1543 |
KEGGi | hsa:1543 |
Organism-specific databases
CTDi | 1543 |
EuPathDBi | HostDB:ENSG00000140465.13 |
PharmGKBi | PA27092 |
Phylogenomic databases
eggNOGi | KOG0156 Eukaryota COG2124 LUCA |
HOVERGENi | HBG106944 |
KOi | K07408 |
OMAi | WEKCLVE |
OrthoDBi | 702827at2759 |
Miscellaneous databases
ChiTaRSi | CYP1A1 human |
GenomeRNAii | 1543 |
Gene expression databases
Bgeei | ENSG00000140465 Expressed in 111 organ(s), highest expression level in liver |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008066 Cyt_P450_E_grp-I_CYP1 IPR036396 Cyt_P450_sf |
Pfami | View protein in Pfam PF00067 p450, 1 hit |
PRINTSi | PR00463 EP450I PR01683 EP450ICYP1A PR00385 P450 |
SUPFAMi | SSF48264 SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | A0N0X8_HUMAN | |
Accessioni | A0N0X8Primary (citable) accession number: A0N0X8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 12, 2006 |
Last sequence update: | December 12, 2006 | |
Last modified: | February 13, 2019 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |