CYP1A1

Functionⁱ

Cytochromes P450 are a group of heme-thiolate monooxygenases.UniRule annotation

Catalytic activityⁱ

an alkane
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See the description of this molecule in ChEBI.
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O₂
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reduced [NADPH—hemoprotein reductase]
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a primary alcohol
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H⁺
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H₂O
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See the description of this molecule in ChEBI.
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oxidized [NADPH—hemoprotein reductase]
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UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU000461
EC:1.14.14.1
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU000461
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
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an alkane
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O₂
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reduced [NADPH—hemoprotein reductase]
FMNH₂
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a primary alcohol
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H⁺
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H₂O
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oxidized [NADPH—hemoprotein reductase]
FMN
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Cofactorⁱ

hemeUniRule annotation

GO - Molecular functionⁱ

aromatase activity Source: UniProtKB-EC
demethylase activity Source: Ensembl
enzyme binding Source: Ensembl
flavonoid 3'-monooxygenase activity Source: Ensembl
heme binding Source: InterPro
iron ion binding Source: InterPro
oxidoreductase activity, acting on diphenols and related substances as donors Source: Ensembl
steroid hydroxylase activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

9-cis-retinoic acid biosynthetic process Source: Ensembl
aging Source: Ensembl
amine metabolic process Source: Ensembl
camera-type eye development Source: Ensembl
cell population proliferation Source: Ensembl
cellular response to copper ion Source: Ensembl
coumarin metabolic process Source: Ensembl
dibenzo-p-dioxin catabolic process Source: Ensembl
digestive tract development Source: Ensembl
flavonoid metabolic process Source: Ensembl
hepatocyte differentiation Source: Ensembl
hydrogen peroxide biosynthetic process Source: Ensembl
insecticide metabolic process Source: Ensembl
maternal process involved in parturition Source: Ensembl
porphyrin-containing compound metabolic process Source: Ensembl
positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
response to antibiotic Source: Ensembl
response to arsenic-containing substance Source: Ensembl
response to drug Source: Ensembl
response to food Source: Ensembl
response to herbicide Source: Ensembl
response to hyperoxia Source: Ensembl
response to hypoxia Source: Ensembl
response to immobilization stress Source: Ensembl
response to iron(III) ion Source: Ensembl
response to lipopolysaccharide Source: Ensembl
response to nematode Source: Ensembl
response to organic cyclic compound Source: Ensembl
response to virus Source: Ensembl
response to vitamin A Source: Ensembl
response to wounding Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	MonooxygenaseUniRule annotation, Oxidoreductase
Ligand	HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450UniRule annotation (EC:1.14.14.1UniRule annotation)
Gene namesⁱ	Name:CYP1A1Imported ORF Names:hCG_40803Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140465.13

EuPathDBⁱ

HostDB:ENSG00000140465.13

Keywords - Cellular componentⁱ

Endoplasmic reticulum, MicrosomeUniRule annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA27092

PharmGKBⁱ

PA27092

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000140465 Expressed in 111 organ(s), highest expression level in liver

Bgeeⁱ

ENSG00000140465 Expressed in 111 organ(s), highest expression level in liver

Interactionⁱ

GO - Molecular functionⁱ

enzyme binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
HOVERGENⁱ	HBG106944
KEGG Orthology (KO) More...KOⁱ	K07408
OMAⁱ	WEKCLVE
Database of Orthologous Groups More...OrthoDBⁱ	702827at2759

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008066 Cyt_P450_E_grp-I_CYP1 IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01683 EP450ICYP1A PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0N0X8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG 
        60         70         80         90        100
HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG 
       110        120        130        140        150
DDFKGRPDLY TFTLISNGQS MSFSPDSGPV WAARRRLAQN GLKSFSIASD 
       160        170        180        190        200
PASSTSCYLE EHVSKEAEVL ISTLQELMAG PGHFNPYRYV VVSVTNVICA 
       210        220        230        240        250
ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL RYLPNPSLNA 
       260        270        280        290        300
FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV 
       310        320        330        340        350
QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV 
       360        370        380        390        400
IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY 
       410        420        430        440        450
IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFLTPDGAID KVLSEKVIIF 
       460        470        480        490        500
GMGKRKCIGE TIARWEVFLF LAILLQRVEF SVPLGVKVDM TPIYGLTMKH 
       510 
ACCEHFQMQL RS

Length:512

Mass (Da):58,165

Last modified:December 12, 2006 - v1

Checksum:ⁱ3C62366044148EFD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF094025 Genomic DNA Translation: ABK41999.1 AK313880 mRNA Translation: BAG36606.1 CH471136 Genomic DNA Translation: EAW99314.1 CH471136 Genomic DNA Translation: EAW99315.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000490.1, NM_000499.4 NP_001306146.1, NM_001319217.1
UniGeneⁱ	Hs.72912

Genome annotation databases

GeneIDⁱ	1543
KEGGⁱ	hsa:1543

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0N0X8	Cytochrome P450 1A1	)	HUMAN		512	UniRef100_P04798
CYP1A1 isoform 7		PANTR		157
Isoform 3 of Cytochrome P450 1A1		HUMAN		157
Cytochrome P450		HUMAN		251
Cytochrome P450 1A1 (Fragment)		HUMAN		175
+1

Protein	Similar proteins		Species	Score	Length	Source
A0N0X8	Cytochrome P450 1A1	)	HUMAN		512	UniRef90_P04798
CYP1A1 isoform 7		PANTR		157
Cytochrome P450		RHIRO		524
Cytochrome P450		RHIBE		512
Cytochrome P450		CERAT		512
+33

Protein	Similar proteins		Species	Score	Length	Source
A0N0X8	Cytochrome P450 1A2	)	HUMAN		516	UniRef50_P05177
Cytochrome P450		PANPA		517
Cytochrome P450		PANTR		517
Cytochrome P450 1A2		PONAB		516
Cytochrome P450		GORGO		516
+777

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF094025 Genomic DNA Translation: ABK41999.1 AK313880 mRNA Translation: BAG36606.1 CH471136 Genomic DNA Translation: EAW99314.1 CH471136 Genomic DNA Translation: EAW99315.1
RefSeqⁱ	NP_000490.1, NM_000499.4 NP_001306146.1, NM_001319217.1
UniGeneⁱ	Hs.72912

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1543
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	1543
KEGGⁱ	hsa:1543

Organism-specific databases

CTDⁱ	1543
EuPathDBⁱ	HostDB:ENSG00000140465.13
PharmGKBⁱ	PA27092

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
HOVERGENⁱ	HBG106944
KOⁱ	K07408
OMAⁱ	WEKCLVE
OrthoDBⁱ	702827at2759

Miscellaneous databases

ChiTaRSⁱ	CYP1A1 human
GenomeRNAiⁱ	1543

Gene expression databases

Bgeeⁱ	ENSG00000140465 Expressed in 111 organ(s), highest expression level in liver

Bgeeⁱ

ENSG00000140465 Expressed in 111 organ(s), highest expression level in liver

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008066 Cyt_P450_E_grp-I_CYP1 IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01683 EP450ICYP1A PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0N0X8_HUMAN
Accessionⁱ	A0N0X8Primary (citable) accession number: A0N0X8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 12, 2006
	Last sequence update:	December 12, 2006
	Last modified:	February 13, 2019
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A0N0X8 (A0N0X8_HUMAN)

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Cytochrome P450

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ