UniProtKB - A0N0R2 (A0N0R2_HUMAN)
Protein
Submitted name:
Burkitt lymphoma receptor 1, GTP binding protein (Chemokine (C-X-C motif) receptor 5)
Gene
BLR1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- C-X-C chemokine receptor activity Source: InterPro
GO - Biological processi
- B cell activation Source: InterPro
- immune response Source: InterPro
- leukocyte chemotaxis Source: Ensembl
- lymph node development Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: Burkitt lymphoma receptor 1, GTP binding protein (Chemokine (C-X-C motif) receptor 5)ImportedSubmitted name: Burkitt lymphoma receptor 1, GTP binding protein (Chemokine (C-X-C motif) receptor 5), isoform CRA_aImportedSubmitted name: C-x-c chemokine receptor type 5Imported |
Gene namesi | Name:BLR1Imported ORF Names:hCG_37947Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000160683.4 |
Subcellular locationi
Plasma Membrane
- external side of plasma membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 52 – 76 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 163 – 182 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 220 – 239 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 260 – 281 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 301 – 325 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000160683, Expressed in lymph node and 120 other tissues |
ExpressionAtlasi | A0N0R2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 322 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 255 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_009579_8_3_1 |
OMAi | IGFTHCC |
OrthoDBi | 794531at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001053, Chemokine_CXCR5 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00564, CXCCHMKINER5 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0N0R2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK
60 70 80 90 100
AVFVPVAYSL IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL
110 120 130 140 150
VFILPFAVAE GSVGWVLGTF LCKTVIALHK VNFYCSSLLL ACIAVDRYLA
160 170 180 190 200
IVHAVHAYRH RRLLSIHITC GTIWLVGFLL ALPEILFAKV SQGHHNNSLP
210 220 230 240 250
RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG VVHRLRQAQR
260 270 280 290 300
RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL
310 320 330 340 350
PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ
360 370
LFPSWRRSSL SESENATSLT TF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF064770 Genomic DNA Translation: ABK41953.1 EF444957 Genomic DNA Translation: ACA05956.1 CH471065 Genomic DNA Translation: EAW67415.1 |
RefSeqi | NP_001707.1, NM_001716.4 |
Genome annotation databases
GeneIDi | 643 |
KEGGi | hsa:643 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF064770 Genomic DNA Translation: ABK41953.1 EF444957 Genomic DNA Translation: ACA05956.1 CH471065 Genomic DNA Translation: EAW67415.1 |
RefSeqi | NP_001707.1, NM_001716.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Chemistry databases
BindingDBi | A0N0R2 |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 18705, 677 antibodies |
DNASUi | 643 |
Genome annotation databases
GeneIDi | 643 |
KEGGi | hsa:643 |
Organism-specific databases
CTDi | 643 |
PharmGKBi | PA162383046 |
VEuPathDBi | HostDB:ENSG00000160683.4 |
Phylogenomic databases
HOGENOMi | CLU_009579_8_3_1 |
OMAi | IGFTHCC |
OrthoDBi | 794531at2759 |
Miscellaneous databases
BioGRID-ORCSi | 643, 4 hits in 868 CRISPR screens |
ChiTaRSi | CXCR5, human |
GenomeRNAii | 643 |
Gene expression databases
Bgeei | ENSG00000160683, Expressed in lymph node and 120 other tissues |
ExpressionAtlasi | A0N0R2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001053, Chemokine_CXCR5 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00564, CXCCHMKINER5 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0N0R2_HUMAN | |
Accessioni | A0N0R2Primary (citable) accession number: A0N0R2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 12, 2006 |
Last sequence update: | December 12, 2006 | |
Last modified: | February 10, 2021 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |