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UniProtKB - A0MNP2 (A0MNP2_HUMAN)
Protein
Submitted name:
CDW11/WDR57
Gene
WDR57
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: CDW11/WDR57ImportedSubmitted name: WD repeat domain 57 (U5 snRNP specific), isoform CRA_aImportedSubmitted name: cDNA FLJ90035 fis, clone HEMBA1001878, highly similar to WD repeat protein 57Imported |
Gene namesi | Name:WDR57Imported ORF Names:hCG_20041Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000060688 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 62 – 95 | WDPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 105 – 146 | WDPROSITE-ProRule annotationAdd BLAST | 42 | |
Repeati | 147 – 189 | WDPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 189 – 230 | WDPROSITE-ProRule annotationAdd BLAST | 42 | |
Repeati | 231 – 265 | WDPROSITE-ProRule annotationAdd BLAST | 35 | |
Repeati | 292 – 322 | WDPROSITE-ProRule annotationAdd BLAST | 31 | |
Repeati | 323 – 357 | WDPROSITE-ProRule annotationAdd BLAST | 35 |
Keywords - Domaini
RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_000288_57_2_1 |
OMAi | WDLRKNA |
OrthoDBi | 1133270at2759 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 7 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 5 hits PS50082, WD_REPEATS_2, 7 hits |
i Sequence
Sequence statusi: Complete.
A0MNP2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIEQQKRKGP ELPLVPVKRQ RHELLLGAGS GPGAGQQQAT PGALLQAGPP
60 70 80 90 100
RCSSLQAPIM LLSGHEGEVY CCKFHPNGST LASAGFDRLI LLWNVYGDCD
110 120 130 140 150
NYATLKGHSG AVMELHYNTD GSMLFSASTD KTVAVWDSET GERVKRLKGH
160 170 180 190 200
TSFVNSCYPA RRGPQLVCTG SDDGTVKLWD IRKKAAIQTF QNTYQVLAVT
210 220 230 240 250
FNDTSDQIIS GGIDNDIKVW DLRQNKLTYT MRGHADSVTG LSLSSEGSYL
260 270 280 290 300
LSNAMDNTVR VWDVRPFAPK ERCVKIFQGN VHNFEKNLLR CSWSPDGSKI
310 320 330 340 350
AAGSADRFVY VWDTTSRRIL YKLPGHAGSI NEVAFHPDEP IIISASSDKR
LYMGEIQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF011621 mRNA Translation: ABK41111.1 AK074516 mRNA Translation: BAG51963.1 CH471059 Genomic DNA Translation: EAX07626.1 |
RefSeqi | NP_004805.2, NM_004814.2 |
Genome annotation databases
GeneIDi | 9410 |
KEGGi | hsa:9410 |
MANE-Selecti | ENST00000263694.9; ENSP00000263694.4; NM_004814.3; NP_004805.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF011621 mRNA Translation: ABK41111.1 AK074516 mRNA Translation: BAG51963.1 CH471059 Genomic DNA Translation: EAX07626.1 |
RefSeqi | NP_004805.2, NM_004814.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A0MNP2, 1 interactor |
Protocols and materials databases
Antibodypediai | 16742, 130 antibodies from 17 providers |
DNASUi | 9410 |
Genome annotation databases
GeneIDi | 9410 |
KEGGi | hsa:9410 |
MANE-Selecti | ENST00000263694.9; ENSP00000263694.4; NM_004814.3; NP_004805.2 |
Organism-specific databases
CTDi | 9410 |
PharmGKBi | PA164726132 |
VEuPathDBi | HostDB:ENSG00000060688 |
Phylogenomic databases
HOGENOMi | CLU_000288_57_2_1 |
OMAi | WDLRKNA |
OrthoDBi | 1133270at2759 |
Miscellaneous databases
BioGRID-ORCSi | 9410, 619 hits in 1090 CRISPR screens |
ChiTaRSi | SNRNP40, human |
GenomeRNAii | 9410 |
Gene expression databases
Bgeei | ENSG00000060688, Expressed in lung and 213 other tissues |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 7 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 5 hits PS50082, WD_REPEATS_2, 7 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A0MNP2_HUMAN | |
Accessioni | A0MNP2Primary (citable) accession number: A0MNP2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 12, 2006 |
Last sequence update: | December 12, 2006 | |
Last modified: | May 25, 2022 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |