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Protein
Submitted name:

NPC1 like intracellular cholesterol transporter 1

Gene

NPC1L1

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
NPC1 like intracellular cholesterol transporter 1Imported
Submitted name:
Niemann-Pick C1-like 1 proteinImported
Gene namesi
Name:NPC1L1Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei284 – 305HelicalSequence analysisAdd BLAST22
Transmembranei351 – 372HelicalSequence analysisAdd BLAST22
Transmembranei633 – 654HelicalSequence analysisAdd BLAST22
Transmembranei666 – 690HelicalSequence analysisAdd BLAST25
Transmembranei696 – 719HelicalSequence analysisAdd BLAST24
Transmembranei739 – 761HelicalSequence analysisAdd BLAST23
Transmembranei773 – 797HelicalSequence analysisAdd BLAST25
Transmembranei843 – 864HelicalSequence analysisAdd BLAST22
Transmembranei1113 – 1133HelicalSequence analysisAdd BLAST21
Transmembranei1140 – 1161HelicalSequence analysisAdd BLAST22
Transmembranei1206 – 1230HelicalSequence analysisAdd BLAST25
Transmembranei1242 – 1265HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5302

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501408326222 – 1332Sequence analysisAdd BLAST1311

Expressioni

Gene expression databases

BgeeiENSMMUG00000000782 Expressed in 8 organ(s), highest expression level in liver
ExpressionAtlasiA0MJA5 baseline

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000001055

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini632 – 797SSDInterPro annotationAdd BLAST166

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1933 Eukaryota
ENOG410XR54 LUCA
GeneTreeiENSGT00900000140845
HOGENOMiHOG000036674
HOVERGENiHBG003913
KOiK14461
OrthoDBiEOG091G00JD
TreeFamiTF300416

Family and domain databases

InterProiView protein in InterPro
IPR004765 NPC1-like
IPR032190 NPC1_N
IPR003392 Ptc/Disp
IPR000731 SSD
PfamiView protein in Pfam
PF16414 NPC1_N, 1 hit
PF02460 Patched, 1 hit
PF12349 Sterol-sensing, 1 hit
TIGRFAMsiTIGR00917 2A060601, 1 hit
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0MJA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAGLRGWL LWALLLHLAQ SEPYTPIHQP GYCAFYDECG KNPELSGGLM
60 70 80 90 100
TLSNVSCLSN TPARNITGDH LILLQRICPR LYTGPNTQAC CSAKQLVSLE
110 120 130 140 150
ASLSITKALL TRCPACSDNF VSLHCHNTCS PNQSLFINVT RVAQLGAGQL
160 170 180 190 200
PAVVAYEAFY QHSFAEQSYD SCSRVHIPAA ATLAVGSMCG VYGSALCNAQ
210 220 230 240 250
RWLNFQGDTG NGLAPLDITF HLLEPGQAVG SGIQPLNEGV ARCNESQGDD
260 270 280 290 300
AVACSCQDCA ASCPAIAHPQ ALDSTFRLGR MPGGLVLIII LCSVFTVVAI
310 320 330 340 350
LLVGLRVAPT RDKSKTVDPK KGTSLSDKLS FSTHTLLGQF FQGWGTWVAS
360 370 380 390 400
WPLTILVLSV IPVVVLAAGL VFTELTTDPV ELWSAPNSQA RSEKAFHDQH
410 420 430 440 450
FGPFFRTNQV ILTAPNRSSY RYDSLLLGPK NFSGILDLDL LLELLELQER
460 470 480 490 500
LRHLQVWSPE AQRNISLQHI CYAPLNPDNT SLSDCCINSL LQYFQNNRTL
510 520 530 540 550
LLLTANQTLM GQTSQVDWRD HFLYCANAPL TFKDGTALAL SCMADYGAPV
560 570 580 590 600
FPFLAVGGYK GKDYSEAEAL IMTFSLNNYP AGDPRLAQAQ LWEEAFLEEM
610 620 630 640 650
RAFQRRTAGK FQVTFMAERS LEDEINRTTA EDLPIFATSY IVIFLYISLA
660 670 680 690 700
LGSYSSWSRV MVDSKATLGL GGVAVVLGAV MAAMGFFSYL GIRSSLIILQ
710 720 730 740 750
VVPFLVLSVG ADNIFIFVLE YQRLPRRPGE PREVHIGRAL GRVAPSMLLC
760 770 780 790 800
SLSEAICFFL GALTPMPAVR TFALTSGLAV VLDFLLQMSA FVALLSLDSK
810 820 830 840 850
RQEASRLDVC CCVKPRELPL PGQGEGFLLG LFRKAYVPFL LHWITRGVVL
860 870 880 890 900
LLFLALFGVS LYYMCHISVG LDQELALPKD SYLLDYFLFL NRYFETGAPV
910 920 930 940 950
YFVTTSGYNF SSEAGMNAIC SSAGCNNFSF TQKIQYATEF PEQSYLAIPA
960 970 980 990 1000
SSWVDDFIDW LTPSSCCRLY ISGPNKDQFC PSTVNSLNCL KNCLSITMGS
1010 1020 1030 1040 1050
VRPSVEQFYK YLPWFLNDRP NIKCPKGGLG AYSTSVNLTS DGQVLASRFM
1060 1070 1080 1090 1100
AYHKPLKNSQ DYTEALRAAR ELAANITADL RKVPGTDPAF EVFPYTVTNV
1110 1120 1130 1140 1150
FYEQYLTILP EGLFMLSLCL VPTFAVCCLL LGLDLRSGLL NLLSIIMILV
1160 1170 1180 1190 1200
DTVGFMALWG ISYNAVSLIN LVSAVGMSVE FVSHITRSFA ISTKPTRLER
1210 1220 1230 1240 1250
AKEATISMGS AVFAGVAMTN LPGILVLGLA KAQLIQIFFF RLNLLITLLG
1260 1270 1280 1290 1300
LLHGLVFLPV ILSYVGPDIN PALALEQKLA EEAAAAAIAA SYPNHPSRVS
1310 1320 1330
TADNIYVNHS FEGSIKGAGA VSNFLPNNGR QF
Length:1,332
Mass (Da):145,588
Last modified:December 12, 2006 - v1
Checksum:iB983F0EBD7E0EFD8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RBI6F6RBI6_MACMU
Uncharacterized protein
NPC1L1
1,286Annotation score:
F6U2U0F6U2U0_MACMU
Uncharacterized protein
NPC1L1
724Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03028340 Genomic DNA No translation available.
JSUE03028341 Genomic DNA No translation available.
DQ897677 mRNA Translation: ABK32535.1
RefSeqiNP_001071157.1, NM_001077689.1
UniGeneiMmu.3142

Genome annotation databases

EnsembliENSMMUT00000001126; ENSMMUP00000001055; ENSMMUG00000000782
GeneIDi699235
KEGGimcc:699235

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03028340 Genomic DNA No translation available.
JSUE03028341 Genomic DNA No translation available.
DQ897677 mRNA Translation: ABK32535.1
RefSeqiNP_001071157.1, NM_001077689.1
UniGeneiMmu.3142

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000001055

Chemistry databases

ChEMBLiCHEMBL5302

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000001126; ENSMMUP00000001055; ENSMMUG00000000782
GeneIDi699235
KEGGimcc:699235

Organism-specific databases

CTDi29881

Phylogenomic databases

eggNOGiKOG1933 Eukaryota
ENOG410XR54 LUCA
GeneTreeiENSGT00900000140845
HOGENOMiHOG000036674
HOVERGENiHBG003913
KOiK14461
OrthoDBiEOG091G00JD
TreeFamiTF300416

Gene expression databases

BgeeiENSMMUG00000000782 Expressed in 8 organ(s), highest expression level in liver
ExpressionAtlasiA0MJA5 baseline

Family and domain databases

InterProiView protein in InterPro
IPR004765 NPC1-like
IPR032190 NPC1_N
IPR003392 Ptc/Disp
IPR000731 SSD
PfamiView protein in Pfam
PF16414 NPC1_N, 1 hit
PF02460 Patched, 1 hit
PF12349 Sterol-sensing, 1 hit
TIGRFAMsiTIGR00917 2A060601, 1 hit
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0MJA5_MACMU
AccessioniPrimary (citable) accession number: A0MJA5
Secondary accession number(s): F6RBH5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: September 12, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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