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Entry version 70 (02 Jun 2021)
Sequence version 2 (10 Aug 2010)
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Protein

Replicase polyprotein 1ab

Gene
N/A
Organism
Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.

By similarity

Inhibits host IFN-beta production. Plays a role in the degradation of the host transcriptional activator CREBBP protein. The degradation of host CREBBP which is a key component of the IFN enhanceosome is likely responsible for the inhibition of interferon mediated by Nsp1-alpha. Participates also in the inhibition of host NF-kappa-B activation by counteracting LUBAC-dependent induction of NF-kappa-B. Reduces host NEMO ubiquitination by blocking the interaction between the two LUBAC complex components RNF31 and SHARPIN.

By similarity

Plays a role in blocking host mRNA nuclear export to the cytoplasm and subversion of host protein synthesis. Additionally, inhibits the interferon-activated JAK/STAT signal transduction by mediating the ubiquitination and subsequent proteasomal degradation of host KPNA1.

By similarity

Multifunctional protein that acts as a viral protease and as a viral antagonist of host immune response. Cleaves the nsp2/nsp3 site in the viral polyprotein. Displays deubiquitinating activity that cleaves both ubiquitinated and ISGylated products and therefore inhibits ubiquitin and ISG15-dependent host innate immunity. Deubiquitinates also host NFKBIA, thereby interfering with NFKBIA degradation and impairing subsequent NF-kappa-B activation.

2 Publications

Plays a role in the inhibition of the immune response by interacting with host IFITM1. This interaction leads to the proteasomal degradation of the IFN-induced antiviral protein IFITM1.

By similarity

Cleaves the majority of cleavage sites present in the C-terminus of the polyprotein. Triggers host apoptosis through caspase-3, -8, and -9 activations. Subverts host innate immune responses through its protease activity. Targets the NF-kappa-B essential modulator NEMO and mediates its cleavage. Blocks host interferon beta induction and downstream signaling by cleaving mitochondrial MAVS, dislodging it from the mitochondria. Impairs host defense by cleaving host mRNA-decapping enzyme DCP1A to attenuate its antiviral activity.

By similarity

Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic.

By similarity

Plays a role in the inhibition of host STAT3 signaling pathway by inducing the degradation of STAT3.

By similarity

Responsible for replication and transcription of the viral RNA genome.

By similarity

Displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity.

By similarity

Plays a role in the inhibition of the secretion of host IL-1beta by the NLRP3 inflammasome through its endonuclease activity. Plays also a role in the inhibition of host type I interferon production by recruiting host OTULIN to promote removal of linear ubiquitination targeting host NEMO.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).By similarity EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei76For Nsp1-alpha papain-like cysteine proteinase activityPROSITE-ProRule annotation1
Active sitei146For Nsp1-alpha papain-like cysteine proteinase activityPROSITE-ProRule annotation1
Active sitei276For Nsp1-beta papain-like cysteine proteinase activityPROSITE-ProRule annotation1
Active sitei345For Nsp1-beta papain-like cysteine proteinase activityPROSITE-ProRule annotation1
Active sitei429For Nsp2 cysteine proteinase activityPROSITE-ProRule annotation1
Active sitei498For Nsp2 cysteine proteinase activityPROSITE-ProRule annotation1
Active sitei1715Charge relay system; for 3C-like serine proteinase activityPROSITE-ProRule annotation1
Active sitei1740Charge relay system; for 3C-like serine proteinase activityPROSITE-ProRule annotation1
Active sitei1793Charge relay system; for 3C-like serine proteinase activityPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3027Zinc 1PROSITE-ProRule annotation1
Metal bindingi3030Zinc 1PROSITE-ProRule annotation1
Metal bindingi3040Zinc 2PROSITE-ProRule annotation1
Metal bindingi3045Zinc 1PROSITE-ProRule annotation1
Metal bindingi3048Zinc 1PROSITE-ProRule annotation1
Metal bindingi3050Zinc 2PROSITE-ProRule annotation1
Metal bindingi3052Zinc 2PROSITE-ProRule annotation1
Metal bindingi3054Zinc 2PROSITE-ProRule annotation1
Metal bindingi3061Zinc 3PROSITE-ProRule annotation1
Metal bindingi3063Zinc 3PROSITE-ProRule annotation1
Metal bindingi3070Zinc 3PROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei3071Involved in mRNA transcription processBy similarity1
Metal bindingi3073Zinc 3PROSITE-ProRule annotation1
Active sitei3592PROSITE-ProRule annotation1
Active sitei3607PROSITE-ProRule annotation1
Active sitei3636PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri8 – 28C4-type; atypicalAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi3168 – 3175ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Helicase, Hydrolase, Multifunctional enzyme, Nuclease, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Serine protease, Thiol protease, Transferase
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host STAT1 by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Viral immunoevasion, Viral RNA replication
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S32.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1ab
Alternative name(s):
ORF1ab polyprotein
Cleaved into the following 16 chains:
Nsp1 (EC:3.4.22.-)
Nsp1-alpha papain-like cysteine proteinase (EC:3.4.22.-)
Alternative name(s):
PCP1-alpha
Nsp1-beta papain-like cysteine proteinase (EC:3.4.22.-)
Alternative name(s):
PCP1-beta
Nsp2 cysteine proteinase (EC:3.4.19.12, EC:3.4.22.-)
Alternative name(s):
CP2
Short name:
CP
Non-structural protein 3
Short name:
Nsp3
Serine protease nsp4 (EC:3.4.21.-)
Short name:
3CLSP
Alternative name(s):
3C-like serine proteinase
Nsp4
Non-structural protein 5-6-7
Short name:
Nsp5-6-7
Non-structural protein 5
Short name:
Nsp5
Non-structural protein 6
Short name:
Nsp6
Non-structural protein 7-alpha
Short name:
Nsp7-alpha
Non-structural protein 7-beta
Short name:
Nsp7-beta
Non-structural protein 8
Short name:
Nsp8
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
Pol
Short name:
RdRp
Alternative name(s):
Nsp9
Helicase nsp10 (EC:3.6.4.12, EC:3.6.4.13)
Short name:
Hel
Alternative name(s):
Nsp10
Non-structural protein 11
Short name:
Nsp11
Non-structural protein 12
Short name:
Nsp12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPorcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri857306 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesArnidovirineaeArteriviridaeunclassified Arteriviridae
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiSus scrofa (Pig) [TaxID: 9823]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000937 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1094 – 1114HelicalSequence analysisAdd BLAST21
Transmembranei1117 – 1137HelicalSequence analysisAdd BLAST21
Transmembranei1162 – 1182HelicalSequence analysisAdd BLAST21
Transmembranei1211 – 1231HelicalSequence analysisAdd BLAST21
Transmembranei1235 – 1255HelicalSequence analysisAdd BLAST21
Transmembranei1450 – 1470HelicalSequence analysisAdd BLAST21
Transmembranei1526 – 1546HelicalSequence analysisAdd BLAST21
Transmembranei1556 – 1576HelicalSequence analysisAdd BLAST21
Transmembranei1592 – 1612HelicalSequence analysisAdd BLAST21
Transmembranei1875 – 1895HelicalSequence analysisAdd BLAST21
Transmembranei1916 – 1936HelicalSequence analysisAdd BLAST21
Transmembranei1960 – 1980HelicalSequence analysisAdd BLAST21
Transmembranei2003 – 2023HelicalSequence analysisAdd BLAST21
Transmembranei2029 – 2048HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Host cytoplasm, Host endoplasmic reticulum, Host membrane, Host nucleus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi429C → A: Lethal. 1 Publication1
Mutagenesisi458D → A: Slight reduction in the ability of Nsp2 to impair NF-kappaB activation. 1 Publication1
Mutagenesisi462S → A: Reduction in the ability of Nsp2 to impair NF-kappaB activation. 1 Publication1
Mutagenesisi463D → A: Lethal. 1 Publication1
Mutagenesisi465D → A: Reduction in the ability of Nsp2 to impair NF-kappaB activation. 1 Publication1
Mutagenesisi498H → A: Lethal. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003970841 – 3838Replicase polyprotein 1abBy similarityAdd BLAST3838
ChainiPRO_00004108301 – 385Nsp1Add BLAST385
ChainiPRO_00003970851 – 180Nsp1-alpha papain-like cysteine proteinaseSequence analysisAdd BLAST180
ChainiPRO_0000397086181 – 385Nsp1-beta papain-like cysteine proteinaseSequence analysisAdd BLAST205
ChainiPRO_0000397087386 – 1446Nsp2 cysteine proteinaseAdd BLAST1061
ChainiPRO_00003970881447 – 1676Non-structural protein 3Add BLAST230
ChainiPRO_00003970891677 – 1879Serine protease nsp4Add BLAST203
ChainiPRO_00003970901880 – 2334Non-structural protein 5-6-7By similarityAdd BLAST455
ChainiPRO_00004231341880 – 2049Non-structural protein 5Add BLAST170
ChainiPRO_00004231352050 – 2065Non-structural protein 6Add BLAST16
ChainiPRO_00004231362066 – 2214Non-structural protein 7-alphaAdd BLAST149
ChainiPRO_00004231372215 – 2334Non-structural protein 7-betaAdd BLAST120
ChainiPRO_00003970912335 – 3020RNA-directed RNA polymeraseBy similarityAdd BLAST686
ChainiPRO_00003970922335 – 2379Non-structural protein 8By similarityAdd BLAST45
ChainiPRO_00003970933021 – 3462Helicase nsp10By similarityAdd BLAST442
ChainiPRO_00003970943463 – 3686Non-structural protein 11By similarityAdd BLAST224
ChainiPRO_00003970953687 – 3838Non-structural protein 12By similarityAdd BLAST152

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. Nsp1 is autocleaved into two subunits, Nsp1-alpha and Nsp1-beta. There are two alternative pathways for processing. Either nsp4-5 is cleaved, which represents the major pathway or the nsp5-6 and nsp6-7 are processed, which represents the minor pathway. The major pathway occurs when nsp2 acts as cofactor for nsp4.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei180 – 181Cleavage; by autolysisSequence analysis2
Sitei385 – 386Cleavage; by autolysis2
Sitei1446 – 1447Cleavage; by CP2Sequence analysis2
Sitei1676 – 1677Cleavage; by 3CLSP2
Sitei1879 – 1880Cleavage; by 3CLSP2
Sitei2049 – 2050Cleavage; by 3CLSP2
Sitei2065 – 2066Cleavage; by 3CLSP2
Sitei2214 – 2215Cleavage; by 3CLSP2
Sitei2334 – 2335Cleavage; by 3CLSP2
Sitei3020 – 3021Cleavage; by 3CLSP2
Sitei3462 – 3463Cleavage; by 3CLSPBy similarity2
Sitei3686 – 3687Cleavage; by 3CLSPBy similarity2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Nsp1-alpha papain-like:

Interacts with host RNF31.

By similarity

Interacts with host DDX18; this interaction redistributes host DDX18 to the cytoplasm.

By similarity

Interacts with host IFITM1.

By similarity

Interacts with host DDX5.

By similarity

Interacts with host DDX18; this interaction redistributes host DDX18 to the cytoplasm.

By similarity

Interacts with host OTULIN.

By similarity

Interacts with host LGALS3.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0MD28

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini69 – 180Peptidase C31PROSITE-ProRule annotationAdd BLAST112
Domaini269 – 385Peptidase C32PROSITE-ProRule annotationAdd BLAST117
Domaini420 – 527Peptidase C33PROSITE-ProRule annotationAdd BLAST108
Domaini1677 – 1879Peptidase S32PROSITE-ProRule annotationAdd BLAST203
Domaini2364 – 2527NiRANPROSITE-ProRule annotationAdd BLAST164
Domaini2765 – 2899RdRp catalyticPROSITE-ProRule annotationAdd BLAST135
Domaini3021 – 3084AV ZBDPROSITE-ProRule annotationAdd BLAST64
Domaini3134 – 3293(+)RNA virus helicase ATP-bindingAdd BLAST160
Domaini3294 – 3423(+)RNA virus helicase C-terminalAdd BLAST130
Domaini3462 – 3559AV-Nsp11N/CoV-Nsp15MPROSITE-ProRule annotationAdd BLAST98
Domaini3561 – 3683NendoUPROSITE-ProRule annotationAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni69 – 182PCP1-alphaBy similarityAdd BLAST114
Regioni269 – 384PCP1-betaBy similarityAdd BLAST116
Regioni418 – 505OTU-likeAdd BLAST88
Regioni728 – 758DisorderedSequence analysisAdd BLAST31
Regioni1027 – 1064DisorderedSequence analysisAdd BLAST38
Regioni1132 – 1255HD1By similarityAdd BLAST124
Regioni1310 – 1334WCCHBy similarityAdd BLAST25
Regioni1451 – 1612HD2By similarityAdd BLAST162
Regioni1902 – 2023HD3By similarityAdd BLAST122

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi740 – 754Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1044 – 1064Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity
The OTU-like region is responsible for the deubiquitinating and deISGylation activities of Nsp2.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the arteriviridae polyprotein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 28C4-type; atypicalAdd BLAST21

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Conserved Domains Database

More...
CDDi
cd21410, 1B_av_Nsp10-like, 1 hit
cd21160, NendoU_av_Nsp11-like, 1 hit
cd21166, NTD_av_Nsp11-like, 1 hit
cd21405, ZBD_av_Nsp10-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.950, 1 hit
2.40.10.10, 2 hits
3.30.40.20, 1 hit
3.90.70.60, 1 hit
3.90.70.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR031932, Arteri_nsp7a
IPR038451, Arteri_nsp7a_sf
IPR008743, Arterivirus_Nsp2_C33
IPR023338, Arterivirus_NSP4_peptidase
IPR008741, AV_PCPalpha
IPR038155, AV_PCPalpha_sf
IPR025773, AV_PCPbeta
IPR038154, AV_PCPbeta_sf
IPR023183, Chymotrypsin-like_C
IPR043502, DNA/RNA_pol_sf
IPR008760, EAV_peptidase_S32
IPR037227, EndoU-like
IPR044348, NSP10_1B_Av
IPR027355, NSP10_Av_ZBD
IPR044320, NSP11_Av_N
IPR044314, NSP11_NendoU_Av
IPR032855, NSP2-B_epitope
IPR032841, NSP2_assoc
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16749, Arteri_nsp7a, 1 hit
PF14757, NSP2-B_epitope, 1 hit
PF14758, NSP2_assoc, 1 hit
PF05410, Peptidase_C31, 1 hit
PF05411, Peptidase_C32, 1 hit
PF05412, Peptidase_C33, 1 hit
PF05579, Peptidase_S32, 1 hit
PF00680, RdRP_1, 1 hit
PF01443, Viral_helicase1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF142877, SSF142877, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51538, AV_CP, 1 hit
PS51961, AV_NSP11N_COV_NSP15M, 1 hit
PS51493, AV_NSP4_PRO, 1 hit
PS51539, AV_PCP_ALPHA, 1 hit
PS51540, AV_PCP_BETA, 1 hit
PS51652, AV_ZBD, 1 hit
PS51958, NENDOU, 1 hit
PS51947, NIRAN, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Replicase polyprotein 1ab (identifier: A0MD28-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGTFSRCMC TPAARVFWNA GQVFCTRCLS ARPLLSPELQ DTDLGVVGLF
60 70 80 90 100
YKPKDKIHWK VPIGIPQVEC TPSGCCWLSA VFPLARMTSG NHNFLQRLVK
110 120 130 140 150
VADVLYRDGC LAPRHLRELQ VYERGCSWYP ITGPVPGMGL FANSMHVSDQ
160 170 180 190 200
PFPGATHVLT NSPLPQRACR QPFCPFEEAH SDVYRWKKFV IFTDSSPNGR
210 220 230 240 250
FRMMWTPESD DSAALEVLPP ELERQVEILT RSFPAHHPIN LADWELTESP
260 270 280 290 300
ENGFSFGTSH SCGHIVQNPN VFDGKCWLTC FLGQSAEVCY HEEHLANALG
310 320 330 340 350
YQTKWGVHGK YLQRRLQVRG MRAVVDPDGP IHVEALSCSQ SWVRHLTLNN
360 370 380 390 400
DVTPGFVRLT SIRIVSNTEP TAFRIFRFGA HKWYGAAGKR ARAKRATKSG
410 420 430 440 450
KDSALAPKIA PPVPTCGITT YSPPTDGSCG WHVLAAIVNR MINGDFTSPL
460 470 480 490 500
PQYNRPEDDW ASDYDLAQAI QCLQLPATVV RNRACPNAKY LIKLNGVHWE
510 520 530 540 550
VEVRSGMAPR SLSRECVVGV CSEGCVAPPY PADGLPKRAL EALASAYRLP
560 570 580 590 600
SDCVSSGIAD FLADPPPQEF WTLDKMLTSP SPERSGFSSL YKLLLEVVPQ
610 620 630 640 650
KCGATEGAFV YAVERMLKDC PSPEQAMALL AKIKVPSSKA PSVSLDECFP
660 670 680 690 700
AGVPADFEPA FQERPRSPGA AVALCSPDAK GFEGTASEEA QESGHKAVHA
710 720 730 740 750
VPLAEGPNNE QVQVVAGEQL ELGGCGLAIG SAQSSSDSKR ENMHNSREDE
760 770 780 790 800
PLDLSHPAPA ATTTLVGEQT PDNPGSDASA LPIAVRGFVP TGPILRHVEH
810 820 830 840 850
CGTESGDSSS PLDLSFAQTL DQPLDLSLAA WPVKATASDP GWVRGRCEPV
860 870 880 890 900
FLKPRKAFSD GDSALQFGEL SESSSVIEFD QTKDTLVADA PVDLTTSNEA
910 920 930 940 950
LSAVDPSEFV ELRRPRHSAQ ALIDRGGPLA DVHAKIKNRV YEQCLQACEP
960 970 980 990 1000
GSRATPATRE WLDKMWDRVD MKTWRCTSQF QAGRILASLK FLPDMIQDTP
1010 1020 1030 1040 1050
PPVPRKNRAS DNAGLKQLVA RWDKKLSVTP PPKSAGLVLD QTVPPPTDIQ
1060 1070 1080 1090 1100
QEDATPSDGL SHASDFSSRV STSWSWKGLM LSGTRLAGSA GQRLMTWVFE
1110 1120 1130 1140 1150
VYSHLPAFIL TLFSPRGSMA PGDWLFAGVV LLALLLCRSY PILGCLPLLG
1160 1170 1180 1190 1200
VFSGSLRRVR LGVFGSWMAF AVFLFSTPSN PVGSSCDHDS PECHAELLAL
1210 1220 1230 1240 1250
EQRQLWEPVR GLVVGPSGLL CVILGKLLGG SRHLWHVILR LCMLTDLALS
1260 1270 1280 1290 1300
LVYVVSQGRC HKCWGKCIRT APAEVALNVF PFSRATRNSL TSLCDRFQTP
1310 1320 1330 1340 1350
KGVDPVHLAT GWRGCWRGES PIHQPHQKPI AYANLDEKKI SAQTVVAVPY
1360 1370 1380 1390 1400
DPSQAIKCLK VLQAGGAIVD QPTPEVVRVS EIPFSAPFFP KVPVNPDCRI
1410 1420 1430 1440 1450
VVDSDTFVAA VRCGYSTAQL VLGRGNFAKL NQTPLRDSAS TKTTGGASYT
1460 1470 1480 1490 1500
LAVAQVSVWT LVHFILGLWF TSPQVCGRGT ADPWCSNPFS YPAYGPGVVC
1510 1520 1530 1540 1550
SSRLCVSADG VTLPLFSAVA QLSGREVGIF ILVLVSLTAL AHRLALKADM
1560 1570 1580 1590 1600
LVVFSAFCAY AWPMSSWLIC FFPILLKWVT LHPLTMLWVH SFLVFCMPAA
1610 1620 1630 1640 1650
GILSLGITGL LWAVGRFTQV AGIITPYDIH QYTSGPRGAA AVATAPEGTY
1660 1670 1680 1690 1700
MAAVRRAALT GRTLIFTPSA VGSLLEGAFR THKPCLNTVN VVGSSLGSGG
1710 1720 1730 1740 1750
VFTIDGRKTV VTAAHVLNGD TARVTGDSYN RMHTFKTSGD YAWSHADDWQ
1760 1770 1780 1790 1800
GVAPVVKVAK GYRGRAYWQT STGVEPGVIG EGFAFCFTNC GDSGSPVISE
1810 1820 1830 1840 1850
SGDLIGIHTG SNKLGSGLVT TPEGETCAIK ETKLSDLSRH FAGPSVPLGD
1860 1870 1880 1890 1900
IKLSPAIVPD VTSIPSDLAS LLASVPVMEG GLSTVQLLCV FFLLWRMMGH
1910 1920 1930 1940 1950
AWTPIVAVGF FLLNEILPAV LVRAVFSFAL FILAWATPWS AQVLMIRLLT
1960 1970 1980 1990 2000
ASLNRNKLSL AFYALGGVVG LAAEIGAFAG RLPELSQALS TYCFLPRVLA
2010 2020 2030 2040 2050
MASYVPIIII GGLHALGVIL WLFKYRCLHN MLVGDGSFSS AFFLRYFAEG
2060 2070 2080 2090 2100
NLRKGVSQSC GMSNESLTAA LACKLSQADL DFLSSLTNFK CFVSASNMKN
2110 2120 2130 2140 2150
AAGQYIEAAY AKALRQELAS LVQVDKMKGI LSKLEAFAET ATPSLDAGDV
2160 2170 2180 2190 2200
VVLLGQHPHG SILDINVGTE RKTVSVQETR SLGGSKFSVC TVVSNTPVDA
2210 2220 2230 2240 2250
LTGIPLQTPT PLFENGPRHR GEEDDLRVER MKKHCVSLGF HNINGKVYCK
2260 2270 2280 2290 2300
IWDKSTGDTF YTDDSRYTQD LAFQDRSADY RDRDYEGVQT APQQGFDPKS
2310 2320 2330 2340 2350
ETPIGTVVIG GITYNRYLIK GKEVLVPKPD NCLEAAKLSL EQALAGMGQT
2360 2370 2380 2390 2400
CDLTAAEVEK LRRIISQLQG LTTEQALNCL LAASGLTRCG RGGLVVTETA
2410 2420 2430 2440 2450
VKIVKYHSRT FTLGPLDLKV TSEAEVKKST EQGHAVVANL CSGVILMRPH
2460 2470 2480 2490 2500
PPSLVDVLLK PGLDTKPGIQ PGHGAGNMGV DGSTWDFETA PTKAELELSK
2510 2520 2530 2540 2550
QIIQACEVRR GDAPNLQLPY KLYPVRGDPE RHGGRLINTR FGDLSYKTPQ
2560 2570 2580 2590 2600
DTKSAIHAAC CLHPNGAPVS DGKSTLGTTL QHGFELYVPT VPYSVMEYLD
2610 2620 2630 2640 2650
SRPDTPFMCT KHGTSKAAAE DLQKYDLSTQ GFVLPGVLRL VRRFIFGHIG
2660 2670 2680 2690 2700
KAPPLFLPST YPAKNSMAGI NGQRFPTKDV QSIPEIDEMC ARAVKENWQT
2710 2720 2730 2740 2750
VTPCTLKKQY CSKPKTRTIL GTNNFIALAH RSALSGVTQA FMKKAWKSPI
2760 2770 2780 2790 2800
ALGKNKFKEL HCTVAGRCLE ADLASCDRST PAIVRWFVAN LLYELAGCEE
2810 2820 2830 2840 2850
YLPSYVLNCC HDLVATQDGA FTKRGGLSSG DPVTSVSNTV YSLIIYAQHM
2860 2870 2880 2890 2900
VLSALKMGHE IGLKFLEEQL KFEDLLEIQP MLVYSDDLVL YAERPTFPNY
2910 2920 2930 2940 2950
HWWVEHLDLM LGFRTDPKKT VITDKPSFLG CRIEAGRQLV PNRDRILAAL
2960 2970 2980 2990 3000
AYHMKAQNAS EYYASAAAIL MDSCACIDHD PEWYEDLICG IARCARQDGY
3010 3020 3030 3040 3050
SFPGPAFFMS MWEKLRSHNE GKKFRHCGIC DAKADHASAC GLDLCLFHSH
3060 3070 3080 3090 3100
FHQHCPVTLS CGHHAGSREC SQCQSPVGAG RSPLDAVLKQ IPYKPPRTVI
3110 3120 3130 3140 3150
MKVGNKTTAL DPGRYQSRRG LVAVKRGIAG NEVDLPDGDY QVVPLLPTCK
3160 3170 3180 3190 3200
DINMVKVACN VLLSKFIVGP PGSGKTTWLL SQVQDDDVIY TPTHQTMFDI
3210 3220 3230 3240 3250
VSALKVCRYS IPGASGLPFP PPARSGPWVR LVASGHVPGR TSYLDEAGYC
3260 3270 3280 3290 3300
NHLDILRLLS KTPLVCLGDL QQLHPVGFDS YCYVFDQMPQ KQLTTIYRFG
3310 3320 3330 3340 3350
PNICAAIQPC YREKLESKAR NTRVVFTTWP VAFGQVLTPY HKDRIGSAIT
3360 3370 3380 3390 3400
IDSSQGATFD IVTLHLPSPK SLNKSRALVA ITRARHGLFI YDPHNQLQEF
3410 3420 3430 3440 3450
FNLIPERTDC NLVFSRGDDL VVLSADNAVT TVAKALGTGP SRFRVSDPRC
3460 3470 3480 3490 3500
KSLLAACSAS LEGSCMPLPQ VAHNLGFYFS PDSPAFAPLP KELAPHWPVV
3510 3520 3530 3540 3550
THQNNRAWPD RLVASMRPID ARYSKPMVGA GYVVGPSTFL GTPGVVSYYL
3560 3570 3580 3590 3600
TLYIRGEPQA LPETLVSTGR IATDCREYLD AAEEEAAKEL PHAFIGDVKG
3610 3620 3630 3640 3650
TTVGGCHHIT SKYLPRTLPK DSVAVVGVSS PGRAAKAMCT LTDVYLPELR
3660 3670 3680 3690 3700
PYLQPETASK CWKLKLDFRD VRLMVWKGAT AYFQLEGLTW SALPDYARFI
3710 3720 3730 3740 3750
QLPKDAVVYI DPCIGPATAN RKVVRTTDWR ADLAVTPYDY GAQNILTTAW
3760 3770 3780 3790 3800
FEDLGPQWKI LGLQPFRRAF GFENTEDWAI LARRMSDGKD YTDYNWDCVR
3810 3820 3830
ERPHAIYGRA RDHTYHFAPG TELQVELGKP RLPPGREP
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Length:3,838
Mass (Da):418,948
Last modified:August 10, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07ADB34E6578FFC9
GO
Isoform Replicase polyprotein 1a (identifier: A0MD28-2) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein

The sequence of this isoform differs from the canonical sequence as follows:
     2380-3838: Missing.

Note: Produced by conventional translation.Curated
Show »
Length:2,379
Mass (Da):257,784
Checksum:i6CAC6C94BDABDF8D
GO
Isoform Truncated polyprotein 1aTF (identifier: P0DJY0-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0DJY0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,268
Mass (Da):139,092
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAR37017 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti666R → Q in strain: Infectious clone SD 01-08. 1
Natural varianti1005R → K in strain: Infectious clone SD 01-08. 1
Natural varianti1012N → S in strain: Infectious clone SD 01-08. 1
Natural varianti3092P → L in strain: Infectious clone SD 01-08. 1
Natural varianti3682Y → H in strain: Infectious clone SD 01-08. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0396342380 – 3838Missing in isoform Replicase polyprotein 1a. CuratedAdd BLAST1459

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY375474 Genomic RNA Translation: AAR37016.1
AY375474 Genomic RNA Translation: AAR37017.1 Different initiation.
DQ489311 Genomic RNA Translation: ABF66340.1
DQ489311 Genomic RNA Translation: ABF66341.1

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY375474 Genomic RNA Translation: AAR37016.1
AY375474 Genomic RNA Translation: AAR37017.1 Different initiation.
DQ489311 Genomic RNA Translation: ABF66340.1
DQ489311 Genomic RNA Translation: ABF66341.1

3D structure databases

SMRiA0MD28
ModBaseiSearch...

Protein family/group databases

MEROPSiS32.002

Family and domain databases

CDDicd21410, 1B_av_Nsp10-like, 1 hit
cd21160, NendoU_av_Nsp11-like, 1 hit
cd21166, NTD_av_Nsp11-like, 1 hit
cd21405, ZBD_av_Nsp10-like, 1 hit
Gene3Di1.20.58.950, 1 hit
2.40.10.10, 2 hits
3.30.40.20, 1 hit
3.90.70.60, 1 hit
3.90.70.70, 1 hit
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR031932, Arteri_nsp7a
IPR038451, Arteri_nsp7a_sf
IPR008743, Arterivirus_Nsp2_C33
IPR023338, Arterivirus_NSP4_peptidase
IPR008741, AV_PCPalpha
IPR038155, AV_PCPalpha_sf
IPR025773, AV_PCPbeta
IPR038154, AV_PCPbeta_sf
IPR023183, Chymotrypsin-like_C
IPR043502, DNA/RNA_pol_sf
IPR008760, EAV_peptidase_S32
IPR037227, EndoU-like
IPR044348, NSP10_1B_Av
IPR027355, NSP10_Av_ZBD
IPR044320, NSP11_Av_N
IPR044314, NSP11_NendoU_Av
IPR032855, NSP2-B_epitope
IPR032841, NSP2_assoc
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF16749, Arteri_nsp7a, 1 hit
PF14757, NSP2-B_epitope, 1 hit
PF14758, NSP2_assoc, 1 hit
PF05410, Peptidase_C31, 1 hit
PF05411, Peptidase_C32, 1 hit
PF05412, Peptidase_C33, 1 hit
PF05579, Peptidase_S32, 1 hit
PF00680, RdRP_1, 1 hit
PF01443, Viral_helicase1, 1 hit
SUPFAMiSSF142877, SSF142877, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51538, AV_CP, 1 hit
PS51961, AV_NSP11N_COV_NSP15M, 1 hit
PS51493, AV_NSP4_PRO, 1 hit
PS51539, AV_PCP_ALPHA, 1 hit
PS51540, AV_PCP_BETA, 1 hit
PS51652, AV_ZBD, 1 hit
PS51958, NENDOU, 1 hit
PS51947, NIRAN, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPOA_PRRSS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0MD28
Secondary accession number(s): A0MD29, Q6U9W7, Q6U9W8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 2, 2021
This is version 70 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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