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Entry version 56 (02 Jun 2021)
Sequence version 1 (12 Dec 2006)
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Protein

Cortactin-binding protein 2

Gene

CTTNBP2

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.

By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cortactin-binding protein 2
Short name:
CortBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTTNBP2
Synonyms:CORTBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFelis catus (Cat) (Felis silvestris catus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9685 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000011712 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002798611 – 1658Cortactin-binding protein 2Add BLAST1658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei495Asymmetric dimethylarginineBy similarity1
Modified residuei1521PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A0M8T5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTTN/cortactin SH3 domain.

Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9685.ENSFCAP00000013875

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0M8T5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati706 – 736ANK 1Add BLAST31
Repeati740 – 769ANK 2Add BLAST30
Repeati773 – 802ANK 3Add BLAST30
Repeati806 – 835ANK 4Add BLAST30
Repeati839 – 868ANK 5Add BLAST30
Repeati909 – 939ANK 6Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni348 – 437DisorderedSequence analysisAdd BLAST90
Regioni451 – 475DisorderedSequence analysisAdd BLAST25
Regioni492 – 614DisorderedSequence analysisAdd BLAST123
Regioni1448 – 1478DisorderedSequence analysisAdd BLAST31
Regioni1538 – 1595DisorderedSequence analysisAdd BLAST58
Regioni1610 – 1642DisorderedSequence analysisAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili120 – 276Sequence analysisAdd BLAST157

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi404 – 424Polar residuesSequence analysisAdd BLAST21
Compositional biasi452 – 475Polar residuesSequence analysisAdd BLAST24
Compositional biasi536 – 554Pro residuesSequence analysisAdd BLAST19
Compositional biasi571 – 604Polar residuesSequence analysisAdd BLAST34
Compositional biasi1543 – 1558Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1580 – 1595Polar residuesSequence analysisAdd BLAST16
Compositional biasi1612 – 1642Polar residuesSequence analysisAdd BLAST31

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QWG2, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A0M8T5

Database of Orthologous Groups

More...
OrthoDBi
264951at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR019131, Cortactin-binding_p2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 1 hit
PF09727, CortBP2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0M8T5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATDGASCEP DFSRAPEDAA GATAEAAKKE FDVDTLSKSE LRMLLSVMEG
60 70 80 90 100
ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK
110 120 130 140 150
KPVCTNPLSI LEAVMAHCRK MQERMSTQLA AAESRQKKLE MEKLQLQAVE
160 170 180 190 200
QEHQKLAARL EEERGKNKHV VLMLVKECKQ LSGKVIEEAQ KLEEVMAKLE
210 220 230 240 250
EEKTKTSALE EELSAEKRRS TEMEAQMEKQ LSEFDTEREQ LRAKLHREEA
260 270 280 290 300
HTTDLKEEID KMKKMIEQLK RGNDSKPSLS LPRKTKDRRV VSISVGTEGP
310 320 330 340 350
VTRSVACQTD LVIESTDHVK KLPLTVPVKP SAGSPLVPAN TKGNVCTGAA
360 370 380 390 400
LGRPGIDRQA SHGDLIGSSP PTVPPPSANR IEENGPSAGS ASSTPPLPNS
410 420 430 440 450
TAPPTVQTPG IAPQSYSQAP PVHSLHSPCA NASLHPGLNP RIQAARFRFQ
460 470 480 490 500
GNANDPDQNG NTTQSPPSRD VSPTSRDNLV AKQLARNTVT QALSRFTSPQ
510 520 530 540 550
AGAPPRPGTA PTGDGGTCPP VGRTSLKTPG VARVDRGNPP PIPPKKPGLS
560 570 580 590 600
QTPSPPHPQL KVIMDSSRAS NAGAKVDNKT MASPPSSLPQ GNRVINEENL
610 620 630 640 650
PKSSSPQLPP KPSIDLTVAP AGCAVSALAT SQVGAWPAET PGLNQPACSE
660 670 680 690 700
SSLVIPTTIA FCSSINTVSA SSCRTGASDS LLVTASGWSP SLTPLLMSGG
710 720 730 740 750
PAPLAGRPTL LQQAATQGNV TLLSMLLNEE GLDINYSCED GHSALYSAAK
760 770 780 790 800
NGHTDCVRLL LNAGAQVNAA DTNGFTPLCA AAAQGHFKCV ELLISYDANI
810 820 830 840 850
NHAADEGQTP LYLACKNGSK ECIQLLLEAG TDRSVKTRDG WTPVHAAVDT
860 870 880 890 900
GNVDSLKLLM YHRAPACRNS LHEEESESVV FDLDQGEESP EGTSKPVVPA
910 920 930 940 950
ELINHADREG WTAAHIAASK GFKNCLEILC MHGGLEPERK DKCHRTAHDV
960 970 980 990 1000
ATDDCKHLLE NLNALKIPLR ISVGEIEPGS YGSDDFECEN TICALNIRKQ
1010 1020 1030 1040 1050
TSWDDFSKAV SQALTNHFQA ISSDGWWSLE DVTFNNTTDS SIGLGTSSVR
1060 1070 1080 1090 1100
SIMLGNVPWS AGQSFTQSPW DFMKKNKAER VTVLLSGPQE GCLSSVTYAS
1110 1120 1130 1140 1150
MIPLQMLQNY LRLVEQYHNV IFHGPEGSLQ DYIAHQLALC MKHRQMAAGF
1160 1170 1180 1190 1200
TCEIVRAEVD AGFSKEQLID LFINSACLIP VKQSPVNKKI IIILENLEKS
1210 1220 1230 1240 1250
SLSELLGDFL APLENRSTES PWTFQKGNGT SECYYFHENC FLMGTIAKAC
1260 1270 1280 1290 1300
LQGSDLLVQQ HFRWVQLRWD GEPMQGLLQR FLRRKVVNKF RGQVPSPCDP
1310 1320 1330 1340 1350
VCKTVDWVLA VWRQLNSCLA RLGTPEALLG PKYFLSCPVV PGHAQATVKW
1360 1370 1380 1390 1400
MAKLWNAIIA PRVQEAILSR ASVKRQPGLG LATAKKHPSQ GQQAVVKAAL
1410 1420 1430 1440 1450
SILLNKAVLH GCPLPRAELD QHAADFRGGS FPLSIVSSYH SYSKKKGESG
1460 1470 1480 1490 1500
AWRKVSTSPR KKSGRFSPPS WNKPGLSEEG IRIKAVSQQN CNRNASLSKQ
1510 1520 1530 1540 1550
KSLENDLSLT LNLDQRLSLG SDDEADLVKE LQSMCSSRSE SDISKIADSR
1560 1570 1580 1590 1600
DDLRRFDGSR NNPAFSTVNP RMPVSPKEVS PLSSHETTEC SNSQSKIELG
1610 1620 1630 1640 1650
VSRVKSFLPV PRSKVTQCSQ NTKRSSSSSN TRQIEINNNT KEEIWNFHQN

EQVEKPNQ
Length:1,658
Mass (Da):180,383
Last modified:December 12, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFCC512CA8C13ACCD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DP000234 Genomic DNA Translation: AAR16238.2

NCBI Reference Sequences

More...
RefSeqi
NP_001162166.1, NM_001168695.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
493673

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
fca:493673

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000234 Genomic DNA Translation: AAR16238.2
RefSeqiNP_001162166.1, NM_001168695.1

3D structure databases

SMRiA0M8T5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000013875

Proteomic databases

PRIDEiA0M8T5

Genome annotation databases

GeneIDi493673
KEGGifca:493673

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83992

Phylogenomic databases

eggNOGiENOG502QWG2, Eukaryota
InParanoidiA0M8T5
OrthoDBi264951at2759

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR019131, Cortactin-binding_p2_N
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 1 hit
PF09727, CortBP2, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTTB2_FELCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0M8T5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 12, 2006
Last modified: June 2, 2021
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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