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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciACEL351607:G1G7K-237-MONOMER
UniPathwayi
UPA00251;UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Acel_0231
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaAcidothermalesAcidothermaceaeAcidothermus
Proteomesi
  • UP000008221 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003008861 – 437Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei271N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiA0LRE5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi351607.Acel_0231

Structurei

3D structure databases

ProteinModelPortaliA0LRE5
SMRiA0LRE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

A0LRE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSPGTDAVS AACFERARAR IPGGVNSPVR AFRAVGGTPR FIQSGAGPYL
60 70 80 90 100
VDVDGNRYVD LVCSWGPLIL GHAHPAVVAA VKQAAERGTS FGAPTEAEIE
110 120 130 140 150
MAEEIARRVP AVEMIRLVNS GTEATMSALR LARAYTNRPL VVKFAGCYHG
160 170 180 190 200
HVDALLSAAG SGVATLGLPG TPGVTPGQAA ETIVLPYNDI DAVRTAFERY
210 220 230 240 250
GGEIACVIVE AAAANMGVVP PEPGFNRALA DIAHENGALL VLDEVLTGFR
260 270 280 290 300
VSSAGWWGRD PVAADLFTFG KVIGGGLPIG AFGGRRDIMQ LLAPAGTVYQ
310 320 330 340 350
AGTLSGNPVA VAAGLATLRE STPDIYARLD HVAAVLARAL RDEFGRIGLP
360 370 380 390 400
HQVQQAGNLF SVFFTTEPVR NYAQATGQEA WRYPPFFHAL LDRGVHPPPS
410 420 430
VYEAWFVSAA HDDAAVNQIL DALPAAVRAA ADARPPG
Length:437
Mass (Da):45,713
Last modified:December 12, 2006 - v1
Checksum:i828795AA4811CA3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA Translation: ABK52005.1
RefSeqiWP_011719069.1, NC_008578.1

Genome annotation databases

EnsemblBacteriaiABK52005; ABK52005; Acel_0231
KEGGiace:Acel_0231

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA Translation: ABK52005.1
RefSeqiWP_011719069.1, NC_008578.1

3D structure databases

ProteinModelPortaliA0LRE5
SMRiA0LRE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351607.Acel_0231

Proteomic databases

PRIDEiA0LRE5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK52005; ABK52005; Acel_0231
KEGGiace:Acel_0231

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG091H04O1

Enzyme and pathway databases

UniPathwayi
UPA00251;UER00317

BioCyciACEL351607:G1G7K-237-MONOMER

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGSA_ACIC1
AccessioniPrimary (citable) accession number: A0LRE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: October 10, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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