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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei146May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciSFUM335543:G1G7I-4223-MONOMER
UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Sfum_4100
OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Taxonomic identifieri335543 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
Proteomesi
  • UP000001784 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002895271 – 257GTP cyclohydrolase FolE2Add BLAST257

Interactioni

Protein-protein interaction databases

STRINGi335543.Sfum_4100

Structurei

3D structure databases

ProteinModelPortaliA0LQR3
SMRiA0LQR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
TIGRFAMsiTIGR00294 TIGR00294, 1 hit

Sequencei

Sequence statusi: Complete.

A0LQR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDVQSRFDS RNIRVDKVGV KDIRYPITVM DKTNGIQHTV ASVNMYVNLP
60 70 80 90 100
REFKGTHMSR FIEILNEFHG NLDIREFPSI LQSVQEHLSA ESAHLELSFS
110 120 130 140 150
YFIKKLSPVT GCAGLMEYGC RVAGSLDSNR GHDLVLEVNV PISTVCPCSK
160 170 180 190 200
EISSYGAHNQ RGMVRLAVRF KKFVWIEDLV RLVECAASSE VYSVLKRPDE
210 220 230 240 250
KFVTESAFDN PKFVEDVVRD IAKELKADQN ISWFLVDVEN FESIHNHSAY

ACIERSK
Length:257
Mass (Da):29,236
Last modified:December 12, 2006 - v1
Checksum:iC4E27A7ADE828D9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000478 Genomic DNA Translation: ABK19765.1
RefSeqiWP_011700878.1, NC_008554.1

Genome annotation databases

EnsemblBacteriaiABK19765; ABK19765; Sfum_4100
KEGGisfu:Sfum_4100

Similar proteinsi

Entry informationi

Entry nameiGCH4_SYNFM
AccessioniPrimary (citable) accession number: A0LQR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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