Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 68 (07 Apr 2021)
Sequence version 1 (12 Dec 2006)
Previous versions | rss
Add a publicationFeedback
Protein

L-lactate transporter

Gene

Sfum_3364

Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proton-coupled L-lactate specific transporter.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the protonophore carbonyl cyanide m-chlorophenylhydrazone (CCCP), but not by valinomycin.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=233 µM for L-lactate1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei119L-lactate1 Publication1
    Binding sitei280L-lactate1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processSymport, Transport

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    SFUM335543:G1G7I-3474-MONOMER

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    L-lactate transporter1 Publication
    Alternative name(s):
    SfMCT1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Ordered Locus Names:Sfum_3364Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri335543 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000001784 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10Cytoplasmic1 Publication10
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 40Helical1 PublicationAdd BLAST30
    Topological domaini41 – 45Periplasmic1 Publication5
    Transmembranei46 – 74Helical1 PublicationAdd BLAST29
    Topological domaini75Cytoplasmic1 Publication1
    Transmembranei76 – 95Helical1 PublicationAdd BLAST20
    Topological domaini96 – 99Periplasmic1 Publication4
    Transmembranei100 – 129Helical1 PublicationAdd BLAST30
    Topological domaini130 – 133Cytoplasmic1 Publication4
    Transmembranei134 – 160Helical1 PublicationAdd BLAST27
    Topological domaini161 – 167Periplasmic1 Publication7
    Transmembranei168 – 187Helical1 PublicationAdd BLAST20
    Topological domaini188 – 227Cytoplasmic1 PublicationAdd BLAST40
    Transmembranei228 – 257Helical1 PublicationAdd BLAST30
    Topological domaini258 – 261Periplasmic1 Publication4
    Transmembranei262 – 290Helical1 PublicationAdd BLAST29
    Topological domaini291 – 292Cytoplasmic1 Publication2
    Transmembranei293 – 313Helical1 PublicationAdd BLAST21
    Topological domaini314 – 316Periplasmic1 Publication3
    Transmembranei317 – 346Helical1 PublicationAdd BLAST30
    Topological domaini347 – 350Cytoplasmic1 Publication4
    Transmembranei351 – 380Helical1 PublicationAdd BLAST30
    Topological domaini381 – 382Periplasmic1 Publication2
    Transmembranei383 – 403Helical1 PublicationAdd BLAST21
    Topological domaini404 – 412Cytoplasmic1 Publication9

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi28L → A: Loss of transport activity. 1 Publication1
    Mutagenesisi119Y → A or F: Loss of transport activity. 1 Publication1
    Mutagenesisi145L → A: Strong decrease in transport activity. 1 Publication1
    Mutagenesisi250H → A: Strong decrease in transport activity. 1 Publication1
    Mutagenesisi250H → F: Loss of transport activity. 1 Publication1
    Mutagenesisi256R → A: No change in transport activity. 1 Publication1
    Mutagenesisi256R → D: Increases transport activity. 1 Publication1
    Mutagenesisi257D → A: Loss of transport activity. 1 Publication1
    Mutagenesisi276N → A: Loss of transport activity. 1 Publication1
    Mutagenesisi280R → A: Abolishes L-lactate binding and L-lactate transport. 1 Publication1
    Mutagenesisi331Y → A: Loss of transport activity. 1 Publication1
    Mutagenesisi331Y → F: No change in transport activity. 1 Publication1
    Mutagenesisi335F → A: Increases transport activity. 1 Publication1
    Mutagenesisi359F → A: Loss of transport activity. 1 Publication1
    Mutagenesisi362C → A: Decrease in transport activity. 1 Publication1
    Mutagenesisi377K → A or D: No change in transport activity. 1 Publication1
    Mutagenesisi378D → A: Loss of transport activity. 1 Publication1
    Mutagenesisi383Y → A: Loss of transport activity. 1 Publication1
    Mutagenesisi383Y → F: Strong decrease in transport activity. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004480011 – 412L-lactate transporterAdd BLAST412

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    335543.Sfum_3364

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1412
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    A0LNN5

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG2223, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_001265_59_7_7

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    AKWWQLA

    Database of Orthologous Groups

    More...
    OrthoDBi
    1594866at2

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR011701, MFS
    IPR020846, MFS_dom
    IPR036259, MFS_trans_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF07690, MFS_1, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF103473, SSF103473, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50850, MFS, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A0LNN5-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MADQQTTMPR WVPLLLGLLG STTCGMLLYA WSVFIKPLNA EFGWSRAEIA
    60 70 80 90 100
    MAFAICCLIF GLMTFPAGRL SDKMGPRKVV MTGGVLLAIG FILSGFIQSK
    110 120 130 140 150
    YQLYITYGVI AGFGGGMIYL PPIATAPKWW PDRRALATGF AVVGLGLGSF
    160 170 180 190 200
    LMGPLATYII EKPGMGWRYV FWYCGVAMGI MALIAGAFLE PPPAGWKPAG
    210 220 230 240 250
    YTPPAPPAGA AAPKVTRDWT YEEAKGDTKF WLLYLAYFCG SFAGLMVIGH
    260 270 280 290 300
    LAGFGRDAGL TAMAAAGAVS SLAFSNAATR ILSGWFVDKI GIRVYFAALF
    310 320 330 340 350
    ALQTAAMIAI FQLGGSVVGL SIVAIVIGWN YGAMFTLFPA TCLQFYGPTA
    360 370 380 390 400
    QGSNYGLLFT ACGLAGFAGP WVGGWLKDTT GTYYLPFLCA AALCALGTAI
    410
    VFMTKPPEKK HA
    Length:412
    Mass (Da):43,800
    Last modified:December 12, 2006 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i139A0300465FDD45
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    CP000478 Genomic DNA Translation: ABK19037.1

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_011700162.1, NC_008554.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    ABK19037; ABK19037; Sfum_3364

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    sfu:Sfum_3364

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP000478 Genomic DNA Translation: ABK19037.1
    RefSeqiWP_011700162.1, NC_008554.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6G9XX-ray2.54A/B1-412[»]
    6HCLX-ray2.69A/B1-412[»]
    SMRiA0LNN5
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    STRINGi335543.Sfum_3364

    Genome annotation databases

    EnsemblBacteriaiABK19037; ABK19037; Sfum_3364
    KEGGisfu:Sfum_3364

    Phylogenomic databases

    eggNOGiCOG2223, Bacteria
    HOGENOMiCLU_001265_59_7_7
    OMAiAKWWQLA
    OrthoDBi1594866at2

    Enzyme and pathway databases

    BioCyciSFUM335543:G1G7I-3474-MONOMER

    Family and domain databases

    InterProiView protein in InterPro
    IPR011701, MFS
    IPR020846, MFS_dom
    IPR036259, MFS_trans_sf
    PfamiView protein in Pfam
    PF07690, MFS_1, 1 hit
    SUPFAMiSSF103473, SSF103473, 1 hit
    PROSITEiView protein in PROSITE
    PS50850, MFS, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSFMCT_SYNFM
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0LNN5
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2019
    Last sequence update: December 12, 2006
    Last modified: April 7, 2021
    This is version 68 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again