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UniProtKB - A0L190 (MDTL_SHESA)
Protein
Multidrug resistance protein MdtL
Gene
mdtL
Organism
Shewanella sp. (strain ANA-3)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: UniProtKB-UniRule
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.1.2.74, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Multidrug resistance protein MdtLUniRule annotation |
Gene namesi | Name:mdtLUniRule annotation Ordered Locus Names:Shewana3_3587 |
Organismi | Shewanella sp. (strain ANA-3) |
Taxonomic identifieri | 94122 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 4 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 5 – 25 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 26 – 41 | PeriplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 42 – 62 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 63 – 64 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 65 – 85 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 86 – 92 | PeriplasmicSequence analysis | 7 | |
Transmembranei | 93 – 113 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 114 – 131 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 132 – 152 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 153 – 157 | PeriplasmicSequence analysis | 5 | |
Transmembranei | 158 – 178 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 179 – 209 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 210 – 230 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 231 – 242 | PeriplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 243 – 263 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 264 – 277 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 278 – 298 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 299 – 319 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 320 – 333 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 334 – 354 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 355 – 360 | PeriplasmicSequence analysis | 6 | |
Transmembranei | 361 – 381 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 382 – 396 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000282001 | 1 – 396 | Multidrug resistance protein MdtLAdd BLAST | 396 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily. [View classification]UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_47_1_6 |
OMAi | MLNGITC |
OrthoDBi | 1452500at2 |
Family and domain databases
HAMAPi | MF_01530, MFS_MdtL, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023697, Multidrug-R_MdtL |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
A0L190-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFRYLLCCFG LVLMYPTGID MYLVGLPQIA NQLGATEAQL HIAFSVYLAG
60 70 80 90 100
MATTMLFAGS LADRIGRKPI TLFSALLFAL ASYFAARSQS SDLFLVARFV
110 120 130 140 150
QGVGAGCCYV VAFAILRDAL DDKRRAKVLS MVNGVTCIIP VIAPVIGHLI
160 170 180 190 200
MLRFPWPSLF YTMAVMGLLV FGLCLFVLRE TYSKASFHSQ TLPRVQTESF
210 220 230 240 250
KQGFFISRVV ITTLGVTTIL SYVNVSPMLI MGQMGFDRGQ YSNTMAMTAL
260 270 280 290 300
VSMLASFSTP FLLNQFKEKS LILFSQTLFA AAALVFILTQ LGWLGQLFNL
310 320 330 340 350
LGFGLVCSGF AIGFGVTMSQ ALSPFVARAG VASSLLGIAQ VCTSALYIWV
360 370 380 390
MGLLEVSAIN ILLAILAVGA LISITLMLAV PKLSEMVANE QIPESA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000469 Genomic DNA Translation: ABK49809.1 |
RefSeqi | WP_011718367.1, NC_008577.1 |
Genome annotation databases
EnsemblBacteriai | ABK49809; ABK49809; Shewana3_3587 |
KEGGi | shn:Shewana3_3587 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000469 Genomic DNA Translation: ABK49809.1 |
RefSeqi | WP_011718367.1, NC_008577.1 |
3D structure databases
SMRi | A0L190 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 94122.Shewana3_3587 |
Protein family/group databases
TCDBi | 2.A.1.2.74, the major facilitator superfamily (mfs) |
Genome annotation databases
EnsemblBacteriai | ABK49809; ABK49809; Shewana3_3587 |
KEGGi | shn:Shewana3_3587 |
Phylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_47_1_6 |
OMAi | MLNGITC |
OrthoDBi | 1452500at2 |
Family and domain databases
HAMAPi | MF_01530, MFS_MdtL, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023697, Multidrug-R_MdtL |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MDTL_SHESA | |
Accessioni | A0L190Primary (citable) accession number: A0L190 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | December 12, 2006 | |
Last modified: | February 23, 2022 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |