Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-acetylgalactosamine-6-phosphate deacetylase

Gene

agaAII

Organism
Shewanella sp. (strain ANA-3)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the pathway of N-acetyl-D-galactosamine degradation. Catalyzes the conversion of N-acetyl-D-galactosamine 6-phosphate to D-galactosamine 6-phosphate and acetate. It can also catalyze the conversion of N-acetyl-D-glucosamine 6-phosphate.1 Publication

Miscellaneous

In Shewanella sp., the active phosphotransferase system (PTS) specific for the transport of GalNAc and GalN is replaced by a set of GalNAc- and GalN-specific permeases and kinases (AgaP and AgaK, respectively).1 Publication

Catalytic activityi

N-acetyl-D-galactosamine 6-phosphate + H2O = D-galactosamine 6-phosphate + acetate.1 Publication
N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi137ZincBy similarity1
Metal bindingi201Zinc; via tele nitrogenBy similarity1
Metal bindingi222Zinc; via tele nitrogenBy similarity1
Binding sitei233SubstrateBy similarity1
Active sitei280Proton donor/acceptorBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • N-acetylglucosamine-6-phosphate deacetylase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17511

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylgalactosamine-6-phosphate deacetylase1 Publication (EC:3.5.1.-1 Publication)
Short name:
GalNAc-6-P deacetylase1 Publication
Alternative name(s):
N-acetylglucosamine-6-phosphate deacetylase1 Publication (EC:3.5.1.251 Publication)
Short name:
GlcNAc-6-P deacetylase1 Publication
Gene namesi
Name:agaAII1 Publication
Ordered Locus Names:Shewana3_2697
OrganismiShewanella sp. (strain ANA-3)
Taxonomic identifieri94122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002589 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004331291 – 394N-acetylgalactosamine-6-phosphate deacetylaseAdd BLAST394

Interactioni

Protein-protein interaction databases

STRINGi94122.Shewana3_2697

Structurei

3D structure databases

ProteinModelPortaliA0KYQ5
SMRiA0KYQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni148 – 149Substrate bindingBy similarity2
Regioni225 – 226Substrate bindingBy similarity2
Regioni254 – 257Substrate bindingBy similarity4
Regioni313 – 315Substrate bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CE4 Bacteria
COG1820 LUCA
HOGENOMiHOG000275008
KOiK01443
OMAiCENADVV
OrthoDBiPOG091H03KA

Family and domain databases

CDDicd00854 NagA, 1 hit
Gene3Di2.30.40.10, 2 hits
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR003764 GlcNAc_6-P_deAcase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PIRSFiPIRSF038994 NagA, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR00221 nagA, 1 hit

Sequencei

Sequence statusi: Complete.

A0KYQ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPNTDFMLI ADGAKVLTQG NLTEHCAIEV SDGIICGLKS TISAEWTADK
60 70 80 90 100
PHYRLTSGTL VAGFIDTQVN GGGGLMFNHV PTLETLRLMM QAHRQFGTTA
110 120 130 140 150
MLPTVITDDI EVMQAAADAV AEAIDCQVPG IIGIHFEGPH LSVAKRGCHP
160 170 180 190 200
PAHLRGITER EWLLYLRQDL GVRLITLAPE SVTPEQIKRL VASGAIISLG
210 220 230 240 250
HSNADGETVL KAIEAGASGF THLYNGMSAL TSREPGMVGA AFASENTYCG
260 270 280 290 300
IILDGQHVHP ISALAAWRAK GTEHLMLVTD AMSPLGSDQT EFQFFDGKVV
310 320 330 340 350
REGMTLRDQH GSLAGSVLDM ASAVRYAATE LNLGLSNAVQ MATRTPAEFI
360 370 380 390
QRPQLGDIAE GKQADWVWLD DDQRVLAVWI AGELLYQAEQ ARFA
Length:394
Mass (Da):42,410
Last modified:December 12, 2006 - v1
Checksum:i1B81D3A886AFF68A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000469 Genomic DNA Translation: ABK48924.1
RefSeqiWP_011717581.1, NC_008577.1

Genome annotation databases

EnsemblBacteriaiABK48924; ABK48924; Shewana3_2697
KEGGishn:Shewana3_2697

Similar proteinsi

Entry informationi

Entry nameiAGAA2_SHESA
AccessioniPrimary (citable) accession number: A0KYQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2015
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again