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UniProtKB - A0KXU5 (RND_SHESA)
Protein
Ribonuclease D
Gene
rnd
Organism
Shewanella sp. (strain ANA-3)
Status
Functioni
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.
UniRule annotationCatalytic activityi
- Exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides.UniRule annotation EC:3.1.13.5
Cofactori
a divalent metal cationUniRule annotation
GO - Molecular functioni
- 3'-5' exonuclease activity Source: InterPro
- nucleic acid binding Source: InterPro
- nucleotide binding Source: InterPro
- ribonuclease D activity Source: UniProtKB-UniRule
GO - Biological processi
- tRNA 3'-end processing Source: UniProtKB-UniRule
Keywordsi
Molecular function | Exonuclease, Hydrolase, Nuclease |
Biological process | tRNA processing |
Names & Taxonomyi
Protein namesi | Recommended name: Ribonuclease DUniRule annotation (EC:3.1.13.5UniRule annotation)Short name: RNase DUniRule annotation |
Gene namesi | Name:rndUniRule annotation Ordered Locus Names:Shewana3_2385 |
Organismi | Shewanella sp. (strain ANA-3) |
Taxonomic identifieri | 94122 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000411072 | 1 – 388 | Ribonuclease DAdd BLAST | 388 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 191 | 3'-5' exonucleaseUniRule annotationAdd BLAST | 168 | |
Domaini | 230 – 310 | HRDCUniRule annotationAdd BLAST | 81 |
Sequence similaritiesi
Belongs to the RNase D family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0349, Bacteria |
HOGENOMi | CLU_042387_0_1_6 |
OMAi | FMRVDTF |
Family and domain databases
Gene3Di | 1.10.150.80, 2 hits 3.30.420.10, 1 hit |
HAMAPi | MF_01899, RNase_D, 1 hit |
InterProi | View protein in InterPro IPR002562, 3'-5'_exonuclease_dom IPR010997, HRDC-like_sf IPR002121, HRDC_dom IPR044876, HRDC_dom_sf IPR006292, RNase_D IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
Pfami | View protein in Pfam PF01612, DNA_pol_A_exo1, 1 hit PF00570, HRDC, 1 hit |
SMARTi | View protein in SMART SM00474, 35EXOc, 1 hit SM00341, HRDC, 1 hit |
SUPFAMi | SSF47819, SSF47819, 2 hits SSF53098, SSF53098, 1 hit |
TIGRFAMsi | TIGR01388, rnd, 1 hit |
PROSITEi | View protein in PROSITE PS50967, HRDC, 1 hit |
i Sequence
Sequence statusi: Complete.
A0KXU5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRLLFLWTV LNPQELEKNL SVFQYVSDEA SLNALVAQYQ QSPLLVLDTE
60 70 80 90 100
FVRTRTYYAK LGLIQAYDGK TLALIDPVAL PDLSAFWSLL DNPNIIKLVH
110 120 130 140 150
SCSEDLEVFA HYGQRQPTPL FDSQIAASLC GMGHGLGYAK LVETCLGEVI
160 170 180 190 200
DKGESRTDWM RRPLTEAQLS YAANDVLYLY QLYPQLADKL KAQDRLGWLY
210 220 230 240 250
EEGERMTEGR LATPDMDTAY LRVKNAFQLT EHQLAYLKVL AKWRLEKALA
260 270 280 290 300
RDLALGFVIK DHGLIALAKK QPKSMGDLLK LNDLTEQEKR IHGKDILRVM
310 320 330 340 350
QTADLSNPPE LVDVLALKPG YKSAFKNIKT CLSELCEQHA IPMEMLGSKR
360 370 380
HIHEYLQWRW DKQQGELPTV LSGWRGQIAA ESLAKLDV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000469 Genomic DNA Translation: ABK48614.1 |
Genome annotation databases
EnsemblBacteriai | ABK48614; ABK48614; Shewana3_2385 |
KEGGi | shn:Shewana3_2385 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000469 Genomic DNA Translation: ABK48614.1 |
3D structure databases
AlphaFoldDBi | A0KXU5 |
SMRi | A0KXU5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 94122.Shewana3_2385 |
Genome annotation databases
EnsemblBacteriai | ABK48614; ABK48614; Shewana3_2385 |
KEGGi | shn:Shewana3_2385 |
Phylogenomic databases
eggNOGi | COG0349, Bacteria |
HOGENOMi | CLU_042387_0_1_6 |
OMAi | FMRVDTF |
Family and domain databases
Gene3Di | 1.10.150.80, 2 hits 3.30.420.10, 1 hit |
HAMAPi | MF_01899, RNase_D, 1 hit |
InterProi | View protein in InterPro IPR002562, 3'-5'_exonuclease_dom IPR010997, HRDC-like_sf IPR002121, HRDC_dom IPR044876, HRDC_dom_sf IPR006292, RNase_D IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
Pfami | View protein in Pfam PF01612, DNA_pol_A_exo1, 1 hit PF00570, HRDC, 1 hit |
SMARTi | View protein in SMART SM00474, 35EXOc, 1 hit SM00341, HRDC, 1 hit |
SUPFAMi | SSF47819, SSF47819, 2 hits SSF53098, SSF53098, 1 hit |
TIGRFAMsi | TIGR01388, rnd, 1 hit |
PROSITEi | View protein in PROSITE PS50967, HRDC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RND_SHESA | |
Accessioni | A0KXU5Primary (citable) accession number: A0KXU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 27, 2011 |
Last sequence update: | December 12, 2006 | |
Last modified: | May 25, 2022 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |